DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32369 and lonrf3

DIOPT Version :9

Sequence 1:	NP_001246660.1	Gene:	CG32369 / 38873	FlyBaseID:	FBgn0052369	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	XP_002934588.3	Gene:	lonrf3 / 100486178	XenbaseID:	XB-GENE-985290	Length:	738	Species:	Xenopus tropicalis

Alignment Length:	916	Identity:	223/916 - (24%)
Similarity:	352/916 - (38%)	Gaps:	273/916 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 SPRISERLDMMPWSRYHHQGKQNQAEQGEFLRGVGESMDEAGDSPLDMHSPTRELRVPSPLQDLE 176
            |.|:.:..|:...:..|   |:..||..|.|           .|.|..|..|:| .:|.|.|.:.
Frog    58 SGRLQDACDLFQRAAMH---KKVCAEDLEAL-----------VSCLADHIRTKE-GLPPPDQRVA 107

  Fly   177 DFDPLMCPLCSDILRCPVTTNCGHTFCRQCCE----TITQCNICQVRFPRIQASSPGPPVCALTT 237
            ....|.|..|......|||..||||||::|.|    :.::|.:|:|
Frog   108 KSAVLTCRQCQGFFFEPVTLLCGHTFCKKCLECQGGSKSECKVCRV------------------- 153

  Fly   238 TTASGAGSSLFTAPSNHNANLSLISFPVGYGVQLSSSVQRLAAPPMTVTTTTVASTTATATTTMA 302

Frog   154 ----------------------------------------------------------------- 153

  Fly   303 STSAAAALGLSAYPSAHGGGIGSTAMKFMPDVLVRRLVEKWWGPDLQAKKISEKASSCMHLNLLD 367
                                  ||...|..:||:..::.||:...::|.::.::.::.......:
Frog   154 ----------------------STEHPFRVNVLLSNILSKWFPSQVKAVRLRQEGNALYKDCKWE 196

  Fly   368 DALKFCNASLEKSPANFKSLCLRAEVLLKLSHYQSSLADIENALRTRCTSPKAHYLRALALSGLG 432
            :||...|.::..:|.:......||.:...|..|..:|.|.|...:.:....|.|..:|.:|..||
Frog   197 EALARYNEAISIAPQDHLLYSNRAMIHFSLKSYGCALQDAETTCKLQPYWLKGHLRKAQSLVNLG 261

  Fly   433 RLEEALYNGFLAICLDKKT------------NLSNSEIFQHDLAKILQRLLAHMPKNRTSLSSAT 485
            |.|::|......:.|:.:.            ||.:.:..|.||.:|||.:...:......|:|.:
Frog   262 RSEDSLKEFLFCLALETENRTAKCEAQKLLLNLLSLQNNQGDLPEILQTMSHPLRLKGNVLNSLS 326

  Fly   486 VPVFQQQHRNFATSRAPYPLLWEQVRRRRKQQHHHHHHHHHHHVHLDDVEDEFGHYNNYIMAGDD 550
            .|......:..           :.|....|:           .|.:.|..|..|:.:.::: ...
Frog   327 TPTPSSNMQRL-----------KMVNMDIKK-----------GVTISDDTDPKGNSSMWLL-HQT 368

  Fly   551 MEEEVE----VEVEGGEPGSLHLDGDFLFPSALDFMDHHRHQRHVFEQKQFDLQPRRHANRKHCK 611
            .|.|:.    .:....||.:       |.|||.:.:                       .||.|.
Frog   369 RESELSCSEMTKAFTPEPAA-------LVPSACNTL-----------------------KRKACS 403

  Fly   612 RKWSVAMESMGGKDLEEEDVDRAHAAGESQRCSRLFAGVLDRTQQELQRLKKLDKSAPSLAVSSV 676
            ::...:.|.:..|.|:.:      ||         ..|.|..           |.|:.|
Frog   404 KETECSSEHIPCKALKRD------AA---------VTGTLGN-----------DHSSAS------ 436

  Fly   677 AGQLIDASDFDCVVCSRTLWKPVVTPCGHTYCLVCLDRCMDYNSPCPLCMSPLVEFNVNASASTS 741
               .:|.||.||.:|.|.|::||.|||||||||.||:||:|:|..||||...|.|:
Frog   437 ---CVDLSDLDCSLCMRLLYEPVTTPCGHTYCLKCLERCLDHNPKCPLCKEDLCEY--------- 489

  Fly   742 ASQHPNPNQNQIHLHPGSSSPVPFALAKRPV--TKFLEAAMKRFIPDHYEAR---FRQEIDQ--- 798
                                     ||.|..  |:.:|..:..:.||..:.|   :.:||.:
Frog   490 -------------------------LAIRTFCKTELMEDLIASYFPDELKDRKTVYEEEIAELSN 529

  Fly   799 -EPSVPVFICTAAFPAVPCPLFVCEPRYRLMVRRAVESGDKTFGIVQPNGGKSRYYDVGTILDIR 862
             ..:||:|:||.|:|.|||||.:.||.||||:||.:|:|.|.||:...:..|. :.|.|.:|:||
Frog   530 LNKNVPIFVCTMAYPTVPCPLHIFEPCYRLMIRRCMETGTKQFGMCIGDSVKG-FADYGCMLEIR 593

  Fly   863 DCVQLGDGCSILSTIGCKRFKILARNEKDGYETAKVEYICDEPIADEQVKILAGMQGVVLAKASE 927
            :.....||.|::.:||.:|||::..:::|||.||.:|||.|.....::...|..:...|..:|..
Frog   594 NVEFFADGRSVVDSIGKRRFKVIRHSQRDGYNTADIEYIEDHKAQGQEYDDLLTLHNAVYDQAFN 658

  Fly   928 WFESLSTEQKHEILQSFGQMPPLEPNWELISDGPAWAWWIIALLPLSQQLKVDILATTSLEKRLR 992
            ||.:|....|..||..||.||..:.:.:...:||||.|||:|:|||..:.::..||.|||:.||.
Frog   659 WFSTLKPALKSRILSHFGPMPANDCDIQANPNGPAWCWWILAVLPLESRAQLPFLAMTSLKDRLT 723

  Fly   993 AIDKTL 998
            .|.:.|
Frog   724 GIRRVL 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32369	NP_001246660.1	RING	183..>206	CDD:302633	11/22 (50%)
		TPR_11	349..412	CDD:290150	12/62 (19%)
		TPR repeat	350..378	CDD:276809	4/27 (15%)
		TPR_11	383..449	CDD:290150	17/65 (26%)
		TPR repeat	383..413	CDD:276809	7/29 (24%)
		RING	687..729	CDD:238093	26/41 (63%)
		LON	791..1005	CDD:271862	84/215 (39%)
		LON_substr_bdg	802..1001	CDD:280370	81/197 (41%)
lonrf3	XP_002934588.3	RING1-HC_LONFs	114..152	CDD:319427	14/37 (38%)
		3a0801s09	<179..>270	CDD:273380	21/90 (23%)
		TPR repeat	179..207	CDD:276809	4/27 (15%)
		TPR repeat	212..242	CDD:276809	7/29 (24%)
		TPR repeat	247..270	CDD:276809	9/22 (41%)
		RING2-HC_LONFs	442..483	CDD:319428	26/40 (65%)
		LON_substr_bdg	533..734	CDD:396663	81/198 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	179	1.000	Domainoid score	I3473
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	356	1.000	Inparanoid score	I2183
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207900at33208
OrthoFinder	1	1.000	-	-		FOG0001000
OrthoInspector	1	1.000	-	-		otm49519
Panther	1	1.100	-	-	O	PTHR23327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X746
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.070