DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32369 and rnf168

DIOPT Version :9

Sequence 1:	NP_001246660.1	Gene:	CG32369 / 38873	FlyBaseID:	FBgn0052369	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	XP_012825502.1	Gene:	rnf168 / 100144920	XenbaseID:	XB-GENE-5765249	Length:	542	Species:	Xenopus tropicalis

Alignment Length:	523	Identity:	101/523 - (19%)
Similarity:	179/523 - (34%)	Gaps:	123/523 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 RVPSPLQDLEDFDPLMCPLCSDILRCPVTTNCGHTFCRQCCE-TITQCNICQVRFPRIQASSPGP 230
            ::|.|      :...:||:|.:||..|||..|.||.|..|.: |:.:.::|             .
Frog    14 KLPLP------WSECICPICQEILLEPVTLPCKHTLCNPCFQMTVEKASLC-------------C 59

  Fly   231 PVCALTTTTASGAGSSLFTAPSNHNANLSLISFPVGYGV--QLSSSVQRLA----APPMTVTTTT 289
            |.|....:|.:          ..|:...:|::..:...:  |.....||.|    :..::...|:
Frog    60 PFCRKRVSTWA----------RQHSRTRTLVNKELWEVIQKQYPKQCQRRASGQESDDLSDELTS 114

  Fly   290 VASTTATATTTMASTSAAAALGLSAYPSAHGGGIGSTAMKFMPDVLVRRLVEKWWGPDLQAKKIS 354
            ...........:.....|....:.|..:|........:..::..:|.....|:....:...::|.
Frog   115 CPVPVLCKPGEIRQEYEAEVSKIEAERTAQEEAERKASEDYIQKLLAEEEAEENLHAEASQREIE 179

  Fly   355 EKASSCMHL-NLLDDALKFCNASLEK-SPANFKSLCLRAEVLLKLSHYQSSLADIENALRTRCTS 417
            |:......| .||...:...|||... ||...|.:..::..::|..  |....|||     |..|
Frog   180 EQLKRDEELARLLSGDMDLSNASCTSVSPVTSKKVVSKSSKIVKSK--QRVSGDIE-----RFLS 237

  Fly   418 PKAHYLRALALSGLGRLEEALYNGFLAICLDKKTNLSNSEIFQHDLA------KILQRLLAHMPK 476
            ||..  ||||..|:.....:..:| ..|.||:..:  ..||  .||:      .::|.....:|
Frog   238 PKPR--RALAAFGINESRNSDTSG-SCILLDEDED--EDEI--PDLSPQCPSTSLIQERDVELP- 294

  Fly   477 NRTSLSSATVPVFQQQHRNFATSRAPY-PLLWEQVRRRRKQQHHHHHHHHHHHVHLDDVEDEFGH 540
                                    .|| |..::.......||              |...:....
Frog   295 ------------------------MPYLPNCYKLESDAASQQ--------------DSCSERNDI 321

  Fly   541 YNNYIMAGDDMEEEVEVEVEGGEPGSLHLDGDFLFPSALDFMDHHRHQRHVFEQKQFDLQPRRHA 605
            .|......|.::.||...:|.....:...:    :....:.|.:...:|.. |:...|::.:..:
Frog   322 CNGTYSCSDSIDVEVSKTMEQQRATADSQE----YRMETNAMSYSTPKRKC-EECYLDIEEKAGS 381

  Fly   606 NRKHCKRKWSVAMES-----MGGK--DLEEEDVDRAHAAGESQRCSRLFAGVLDRTQQELQRLKK 663
            .:...|:|.|::.:|     ..||  :|||...:|.    :.:...||||         ||..::
Frog   382 CQSVKKKKLSLSEDSPVLSVHAGKFIELEENLYERR----KQEEHDRLFA---------LQLQRE 433

  Fly   664 LDK 666
            |||
Frog   434 LDK 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32369	NP_001246660.1	RING	183..>206	CDD:302633	12/22 (55%)
		TPR_11	349..412	CDD:290150	16/64 (25%)
		TPR repeat	350..378	CDD:276809	8/28 (29%)
		TPR_11	383..449	CDD:290150	18/65 (28%)
		TPR repeat	383..413	CDD:276809	6/29 (21%)
		RING	687..729	CDD:238093
		LON	791..1005	CDD:271862
		LON_substr_bdg	802..1001	CDD:280370
rnf168	XP_012825502.1	RING-HC_RNF168	24..65	CDD:319464	17/53 (32%)
rnf168	XP_012825502.1	RING-HC finger (C3HC4-type)	24..62	CDD:319464	16/50 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D458276at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010