DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32369 and si:ch1073-440b2.1

DIOPT Version :9

Sequence 1:	NP_001246660.1	Gene:	CG32369 / 38873	FlyBaseID:	FBgn0052369	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	XP_001340443.6	Gene:	si:ch1073-440b2.1 / 100000190	ZFINID:	ZDB-GENE-030131-8303	Length:	749	Species:	Danio rerio

Alignment Length:	987	Identity:	229/987 - (23%)
Similarity:	368/987 - (37%)	Gaps:	344/987 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 AESFAKVGSLPEAFDVYELIASRQFDGHVPLDKLNTLASALTTHIRQMGGIATPTPTPTPTPMSA 107
            |::.|:.|.:.:|.|.|.:.|:.|   .:..|:|..|...:|..||
Zfish    67 ADALARGGRIADALDSYCIAANIQ---ALKPDELQILVEVITNTIR------------------- 109

  Fly   108 VHVKSPRISERLDMMPWSRYHHQGKQNQAEQGEFLRGVG------ESMDEAGDSPLDMHSPTREL 166
                                    .:.|.|......|..      ||.:...:..||:.|
Zfish   110 ------------------------TKEQCESKNVSVGCNSEVRCFESDESVEEHNLDLFS----- 145

  Fly   167 RVPSPLQDLEDFDPLMCPLCSDILRCPVTTNCGHTFCRQCCET--ITQCNICQVRFPRIQASSPG 229
                            |.||..:|..|.|..||||||::|.|.  ..:|..|
Zfish   146 ----------------CCLCKCLLTEPTTLVCGHTFCKRCLENDLKRECRSC------------- 181

  Fly   230 PPVCALTTTTASGAGSSLFTAPSNHNANLSLISFPVGYGVQLSSSVQRLAAPPMTVTTTTVASTT 294
                 |..||.|         |...|.:
Zfish   182 -----LLKTTKS---------PKQFNVD------------------------------------- 195

  Fly   295 ATATTTMASTSAAAALGLSAYPSAHGGGIGSTAMKFMPDVLVRRLVEKWWGPDLQAKKISEKASS 359
                            ||..                  :|::..|::||:..:.:.::...:...
Zfish   196 ----------------GLRV------------------NVIISGLIDKWFNTESKVRRYWMEGEY 226

  Fly   360 CMHLNLLDDALKFCNASLEKSPANFKSLCLRAEVLLKLSHYQSSLADIENALRTRCTSPKAHYLR 424
            ......|.:|:...|.::::.|:..:.|..|||:.:::.::..::.|.:...:.|...|:|||::
Zfish   227 LWEKQDLSNAMLKFNTAIDQEPSIGRLLAQRAELCMEMKNFSQAIKDGDTMCQLRPLWPRAHYIK 291

  Fly   425 ALALSGLGRLEEALYN---------GFLAICLDKKTNLSN--SEIFQHD-LAKILQRLLAHMPKN 477
            |.||...|..||||..         .::|:.|:.:..||:  |.:|.:| ||..|....:.:  .
Zfish   292 ATALRSAGSSEEALQEYLFCAALKPDWIAVKLEAQKILSHMFSSVFVNDGLATSLPACTSRI--K 354

  Fly   478 RTSLSSATVPVFQQQHRNFATSRAPYPLLWEQVRRRRKQQHHHHHHHHHHHVHLDDVEDEFGHYN 542
            .|||.|:...:..:.......|: ...|...:::....|
Zfish   355 PTSLLSSLNTIIPRDGTKAGCSK-DLTLSCSKIKDGNSQ-------------------------- 392

  Fly   543 NYIMAGDDMEEEVEVEVEGGEPGSLHLDGDFLFPSALDFMDHHRHQRHVFEQKQFDLQPRRHANR 607
                    :.|.|         ..:.|...|: |..|
Zfish   393 --------LSENV---------NCVGLSSLFI-PPVL---------------------------- 411

  Fly   608 KHCKRKW--SVAMESMGGKDLEEEDVDRAHAAGESQRCSRLFAGVLDRTQQELQRLKKLDKSAPS 670
               ||||  :........|.|:|:.|               |:..:.:.|..|
Zfish   412 ---KRKWTENSKQSEPPSKQLKEDHV---------------FSSAVVKRQVPL------------ 446

  Fly   671 LAVSSVAGQLIDASDFDCVVCSRTLWKPVVTPCGHTYCLVCLDRCMDYNSPCPLCMSPLVEFNVN 735
                    ||:|.:||:|.:|.|..::||.||||||:||.||:||:|:|..||||...|.|:
Zfish   447 --------QLLDNADFECSLCMRLFYEPVTTPCGHTFCLKCLERCLDHNPNCPLCKENLSEY--- 500

  Fly   736 ASASTSASQHPNPNQNQIHLHPGSSSPVPFALAKRPVTK--FLEAAMKRFIPDH-------YEAR 791
                                           ||.|...|  .:|..:::::.|.       ||..
Zfish   501 -------------------------------LATRAYCKTLLIEELLQQYLSDELTERRKVYEEE 534

  Fly   792 FRQEIDQEPSVPVFICTAAFPAVPCPLFVCEPRYRLMVRRAVESGDKTFGIVQPNGGKSRYYDVG 856
            .::..:....||:|:||.|||.:||||.|.|||||||:||::|:|.|.||:...:..|. :.|.|
Zfish   535 MKELSNLNQEVPIFVCTMAFPTIPCPLHVFEPRYRLMIRRSLETGTKQFGMCIADELKG-FADHG 598

  Fly   857 TILDIRDCVQLGDGCSILSTIGCKRFKILARNEKDGYETAKVEYICDEPIADEQVKILAGMQGVV 921
            .:|.:||.....||.|::.|||..|||:|:..::|||.|||:||:.|:....|.:..|..:...|
Zfish   599 CMLAVRDVKFFPDGRSVVDTIGIARFKVLSHGQRDGYHTAKIEYLEDKKAEGEDLTELLKLHDSV 663

  Fly   922 LAKASEWFESLSTEQKHEILQSFGQMPPLEPNWELISDGPAWAWWIIALLPLSQQLKVDILATTS 986
            ..:|..||.||..:.|::|:..||.:|..:|:.:...:||||.||::|:|||..:.::.|||..:
Zfish   664 YDQAMAWFTSLKDDMKNQIISHFGPLPVKDPDPQGNPNGPAWCWWLLAVLPLENKAQLTILAMNT 728

  Fly   987 LEKRLRAIDKTL 998
            |:.||.||.:.|
Zfish   729 LKGRLIAIRRVL 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32369	NP_001246660.1	RING	183..>206	CDD:302633	12/22 (55%)
		TPR_11	349..412	CDD:290150	9/62 (15%)
		TPR repeat	350..378	CDD:276809	3/27 (11%)
		TPR_11	383..449	CDD:290150	20/74 (27%)
		TPR repeat	383..413	CDD:276809	5/29 (17%)
		RING	687..729	CDD:238093	23/41 (56%)
		LON	791..1005	CDD:271862	85/208 (41%)
		LON_substr_bdg	802..1001	CDD:280370	85/197 (43%)
si:ch1073-440b2.1	XP_001340443.6	RING_Ubox	146..181	CDD:327409	15/34 (44%)
		TPR repeat	220..245	CDD:276809	3/24 (13%)
		TPR_11	230..>329	CDD:330823	24/98 (24%)
		TPR repeat	250..280	CDD:276809	5/29 (17%)
		TPR repeat	285..308	CDD:276809	12/22 (55%)
		RAD18	446..>546	CDD:333230	39/153 (25%)
		RING2-HC_LONFs	453..494	CDD:319428	24/40 (60%)
		RING-HC finger (C3HC4-type)	456..493	CDD:319428	21/36 (58%)
		LON_substr_bdg	544..745	CDD:308028	85/198 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579764
Domainoid	1	1.000	172	1.000	Domainoid score	I3668
eggNOG	1	0.900	-	-		E1_COG2802
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2704
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207900at33208
OrthoFinder	1	1.000	-	-		FOG0001000
OrthoInspector	1	1.000	-	-		otm25890
orthoMCL	1	0.900	-	-		OOG6_101814
Panther	1	1.100	-	-	LDO	PTHR23327
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2251
SonicParanoid	1	1.000	-	-		X746
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.830