DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clk and NCOA3

DIOPT Version :9

Sequence 1:	NP_001014576.1	Gene:	Clk / 38872	FlyBaseID:	FBgn0023076	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_858045.1	Gene:	NCOA3 / 8202	HGNCID:	7670	Length:	1424	Species:	Homo sapiens

Alignment Length:	1469	Identity:	284/1469 - (19%)
Similarity:	466/1469 - (31%)	Gaps:	586/1469 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EKKRRDQFNSLVNDLSALISTS-------SRKMDKSTVLKSTIAFLKNHNEATDRSKVFEIQQDW 81
            ||:||:|.:..:.:|:.|||.:       :.|.||..:||.|:..::   :..::.|......|.
Human    34 EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIR---QIKEQGKTISNDDDV 95

  Fly    82 KPAFLSN--------DEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTIYDL 138
            :.|.:|:        |....|:|::||||:.|.:..|:|.:.||::|..|.|..:||.|.::|::
Human    96 QKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNI 160

  Fly   139 AYEMDHEALLNIFMNPTPVIEPRQTDISSSNQITFYTHLRRGGMEKVDANAYELVKFVGYFRNDT 203
            .:|.|.:..|            :....|:.|.:::....:|  .:....|...|:|.......|.
Human   161 LHEEDRKDFL------------KNLPKSTVNGVSWTNETQR--QKSHTFNCRMLMKTPHDILEDI 211

  Fly   204 NTS---------------TGSSSEVSNGSNGQPAVL---------PRIFQQNPNA-----EVDKK 239
            |.|               :...:.:..|.:.|..::         .|.|..||.:     ::..|
Human   212 NASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGK 276

  Fly   240 LVFVGTGRVQN------PQLIRE-----MSIIDPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPF 293
            :|.:.|..:::      ..:||.     .|:.|..|  ::.|...:..:| ..|...|:
Human   277 VVNIDTNSLRSSMRPGFEDIIRRCIQRFFSLNDGQS--WSQKRHYQEAYL-NGHAETPV------ 332

  Fly   294 EVLGTSGYDYYHFDDLDSIVACHEELRQTGEGKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPD 358
                      |.|...|..:.       |.:.||..:|......:..::.| :::...|...:|:
Human   333 ----------YRFSLADGTIV-------TAQTKSKLFRNPVTNDRHGFVST-HFLQREQNGYRPN 379

  Fly   359 -----------YVVCTHKV--------------VSYAEVLKDSRKEGQKSG-------------- 384
                       ...|...|              .|.|..|.|....||.||
Human   380 PNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQMSGARYGGSSNIASLTP 444

  Fly   385 -----------NSN------------------------SITNNGSSKV--------------IAS 400
                       |:|                        |..|.||.|:              :||
Human   445 GPGMQSPSSYQNNNYGLNMSSPPHGSPGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMAS 509

  Fly   401 TGTSSKSASATTTLRDFELSSQNLDSTLLGNSLASLGTETAATSPAVDSSPMWSASAVQPSG--- 462
            :|.:...:.::::|...:..|:.:.::|| ::|:|.|       |.:|:||  :.:..|||.
Human   510 SGNTGNHSFSSSSLSALQAISEGVGTSLL-STLSSPG-------PKLDNSP--NMNITQPSKVSN 564

  Fly   463 ---------SCQINPL---------------KTSRPASSYGNISSTG-ISPKAKRK------CYF 496
                     .|..||:               |.|:.:|..|..:..| :..|..:|      | .
Human   565 QDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLESKGHKKLLQLLTC-S 628

  Fly   497 YNNRGNDS-------DSTSMSTDSVTSRQSMMTH----VSSQSQRQRSHHREHHR------ENHH 544
            .::||:.|       .|...|:.||||...:.:.    |||.|....|..:|.||      :|.:
Human   629 SDDRGHSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGN 693

  Fly   545 NQSH---------------------HHMQQQQQHQNQQQQHQQ---------------HQQLQQQ 573
            :.:.                     .::.:|:|...:::::..               .::||.|
Human   694 SPAEVAKITAEATGKDTSSITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQ 758

  Fly   574 LQHT------------------------------------------------------------- 577
            ::..
Human   759 VEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSH 823

  Fly   578 VGTPKMV----PLLPIASTQ------------------IMAG------NACQFPQ-PAYPL--AS 611
            :||.:.|    ..|.:.|:|                  :..|      |...||. |..|:  .:
Human   824 LGTKQQVFQGTNSLGLKSSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGN 888

  Fly   612 PQLV---------------------APTF------------LEP----------PQYLTAIPMQP 633
            |:::                     .|:.            :||          ..|.|::|...
Human   889 PRMMDSQENYGSSMGGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPA 953

  Fly   634 VIAPFPVAPVLS-PLP-----VQSQTDML---PDTVVM----TP-TQSQLQDQL----------- 673
            :....|..|:.| .:|     :|.|..||   |..:.|    .| .|:...:||
Human   954 LGGSIPTLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSME 1018

  Fly   674 QRKH---------DELQKLI-----LQQQNELRIVSEQL-----------------------LLS 701
            |..|         :.|..|:     |:.|::.|.:.:||                       |::
Human  1019 QVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVN 1083

  Fly   702 RYTYLQPMMS--MGFAPGNMTAAAVGNLG----ASG---QRGLNFTGS----NAVQPQFNQYG-F 752
            :...|:|...  .|.....|.....|..|    |.|   |.|.:..|.    |::..|.||.| |
Human  1084 QGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMNQMNQQGNF 1148

  Fly   753 AL-------NSEQMLNQQDQQMMMQQQQNLHTQHQHNLQQQ------------------------ 786
            .|       |..:......:|:.||.||.|..|...|..:|
Human  1149 PLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTAGGAAVMRPMMQPQ 1213

  Fly   787 --------------HQSHSQLQQHTQQQH--QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQL 835
                          .:|...|..|.:||.  ...|||||||||||||||||||||||||||||..
Human  1214 VSSQQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQ 1278

  Fly   836 QLQQQNDILLREDIDDIDAFLNLSPLHSLGSQSTINPFNSSSNNNNQSYNGGSNLNNGNQNNN-- 898
            ......::.....:|.:.|          |......|        .|.:....|...|.|.:.
Human  1279 AFSPPPNVTASPSMDGLLA----------GPTMPQAP--------PQQFPYQPNYGMGQQPDPAF 1325

  Fly   899 NRSSNPPQNNNEDSLLSCMQMATESSPSINFHMGISDDGSETQSEDNKMMHTSGSNLVQQQQQQQ 963
            .|.|:||.          ..|::...||.|..|......|..||  ::|......||.:.....|
Human  1326 GRVSSPPN----------AMMSSRMGPSQNPMMQHPQAASIYQS--SEMKGWPSGNLARNSSFSQ 1378

  Fly   964 QQQQILQQHQQQSNSFFSSNPFLNSQN-----QNQNQLP 997
                  ||...|.|....|...:|..:     .|.|.:|
Human  1379 ------QQFAHQGNPAVYSMVHMNGSSGHMGQMNMNPMP 1411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	15/50 (30%)
		PAS	93..153	CDD:214512	21/59 (36%)
		PAS	264..366	CDD:238075	16/112 (14%)
		PAS_11	265..368	CDD:291273	16/127 (13%)
NCOA3	NP_858045.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		2/3 (67%)
		HLH	34..88	CDD:197674	15/56 (27%)
		PAS	116..173	CDD:214512	21/68 (31%)
		PAS	117..215	CDD:279347	28/111 (25%)
		PAS_11	265..375	CDD:291273	21/136 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..493		15/84 (18%)
		NCOA_u2	459..572	CDD:293270	22/122 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..520		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..674		36/147 (24%)
		SRC-1	620..704	CDD:285981	20/84 (24%)
		LXXLL motif 1	685..689		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..730		2/20 (10%)
		DUF4927	723..810	CDD:292896	5/86 (6%)
		LXXLL motif 2	738..742		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..798		3/42 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..945		3/33 (9%)
		Interaction with CREBBP. /evidence=ECO:0000269\|PubMed:9346901	1023..1093		10/69 (14%)
		Nuc_rec_co-act	1045..1092	CDD:285967	7/46 (15%)
		LXXLL motif 3	1057..1061		1/3 (33%)
		Acetyltransferase	1097..1304		63/216 (29%)
		polyglutamine repeats	1248..1276		27/27 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1273..1321		11/65 (17%)
		DUF1518	1291..1348	CDD:284808	16/84 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810