DRSC/TRiP Functional Genomics Resources

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Protein Alignment Clk and ncoa2

DIOPT Version :9

Sequence 1:NP_001014576.1 Gene:Clk / 38872 FlyBaseID:FBgn0023076 Length:1027 Species:Drosophila melanogaster
Sequence 2:NP_571852.1 Gene:ncoa2 / 81884 ZFINID:ZDB-GENE-010406-3 Length:1505 Species:Danio rerio


Alignment Length:1528 Identity:285/1528 - (18%)
Similarity:446/1528 - (29%) Gaps:608/1528 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 KDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTS-------SRKMDKSTVLKSTIAFLKNH 65
            |:.....|....:..:||:.|:..:..:.:|:.||..:       :.|.||..:||.|:      
Zfish    20 KEGPSDLLGPSPKRSTEKRNREHESKYIEELAELIFANFNDIDNFNVKPDKCAILKETV------ 78

  Fly    66 NEATDRSKVFEIQQDWKPAFLSNDEYTH------------------LMLESLDGFMMVFSSMGSI 112
                  .::.:|::..|.|..:.||...                  :|||:||||..|.:..|:|
Zfish    79 ------KQIRQIKEQEKAAAANEDEVQKADVSSTGQSVIDKDALGPMMLEALDGFFFVVNMEGNI 137

  Fly   113 FYASESITSQLGYLPQDLYNMTIYDLAYEMDH-EALLNIF----MNPTP--VIEPRQTDISSSNQ 170
            .:.||::|..|.|..::|.|.::|.:.:..|| |.:.|:.    :|..|  ...||:      |.
Zfish   138 VFVSENVTQYLRYNQEELMNTSVYSILHVGDHAEFIKNLLPKSHVNGVPWSSENPRR------NS 196

  Fly   171 ITFYTHLRRGGMEKVDANAYELVKFVGYFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAE 235
            .||...:    :....:.|.|........:.:|......|...|....|:              :
Zfish   197 HTFNCRM----LVNPHSEAEETQDHEAQQKYETMQCFAVSEPKSIKEEGE--------------D 243

  Fly   236 VDKKLVFVGTGRV---QNPQLIREMSIIDPTSNEFTSKHSMEWKFLFLDH---RAPPIIGYMPFE 294
            ....|:.|.. ||   :.|.|        ||...||::..::.|...||.   ||....|:   |
Zfish   244 FQSCLICVAR-RVPMKERPML--------PTQESFTTRQDLQGKITSLDTSLLRASMKPGW---E 296

  Fly   295 VLGTSGYDYYHFD---DLDSIVACHEELRQTGEGKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSK 356
            .|.......:|..   |:.......:|:.:.|:..|..|||.......:...|...:......::
Zfish   297 DLVRRCIQRFHLQNDGDISFAKRHQQEVIRHGQAFSPIYRFSLSDGTIVSAHTKSKLVRSSSTNE 361

  Fly   357 PDYVVCTH------KVVSYAEVLKDSRKEGQ-----KSGNS--NSITNNGSSKVIAST------- 401
            |...:..|      .|...|..|.:::..|:     .|.|:  :|.|..|....|:|.       
Zfish   362 PQLYMSLHILQREQPVCGMASDLGNAQTMGKPMNPMSSPNTAGSSCTPQGQDATISSNTSTFPSP 426

  Fly   402 ---------------GTSSKSA---SATTTLRDFELS----SQNLDSTLLGNSLASLGTETAATS 444
                           ||.|.||   :||.....:.|.    ||.....|.....||.|...:...
Zfish   427 GAQKEPGAMHRFGCPGTMSHSATMQAATPQGSGYPLKLSSPSQGSPGMLSPRHRASPGVAGSPRL 491

  Fly   445 PAVDSSPMWSASAVQPSGSCQINPLKTSRPASSYGNISSTGISPKAKRKCYFYNNRGNDSDSTSM 509
            |....||  :.|...|:..|..:........:::|..||:..:.:|..:|:..:: |....|...
Zfish   492 PPPQFSP--AGSLHSPASMCTSSTGGNGGAGANHGYTSSSLNALQALSECHGVSH-GQSLGSPDR 553

  Fly   510 STDSVTSRQSMMTH-----------VSSQSQRQR---------------------------SHHR 536
            ...|..:....::|           ...|:|.::                           |..:
Zfish   554 KLGSPAAHSVAVSHHLINKMSVPESFGEQNQSEQGTPGQDEGIDLPRDEKGNLGQFGNLDGSDPQ 618

  Fly   537 EHHRENHHNQSHHHMQQ--------------------------------QQQHQNQQQQH----- 564
            ...|:   |:||..:.|                                ....|.....|     
Zfish   619 SRLRD---NKSHTKLLQLLTTKTEPIESTSPPPMAGGEPGCKDGGAGNGGMGSQGGNGSHATSLK 680

  Fly   565 QQHQQLQQQLQH--------------------------TVGTP----KMVPLLP----------- 588
            ::|:.|.:.||:                          |.|.|    |..|:.|           
Zfish   681 EKHKILHRLLQNSSSPVDLAKLTAEATGKELCQDSAGGTAGVPELAIKQEPVSPKKKDNALLRYL 745

  Fly   589 -----------------------------IASTQIMAG--------------NACQFPQP----- 605
                                         |.:.:...|              :..|..||     
Zfish   746 LDKDDNVLKGKGIKMEPGEIKEEGGKMTGIKTEKTDGGYDRVEPSSELDDILDDLQNSQPGLFTD 810

  Fly   606 AYPLASPQLV---------------APTFLEPPQ---YLTAIPMQPVIAPFPVAPVLSPLPVQS- 651
            :.|::.|..|               :...:.|.|   ..||:..|...||.|..|..:| ||:| 
Zfish   811 SRPVSLPSAVDKQSIINDILQMTGESGANMSPQQQRALQTAVSQQNFPAPRPGQPGRAP-PVRSV 874

  Fly   652 QTDMLPDTVVMTPTQSQLQDQLQRKHDELQKLILQQQ-----------------------NELRI 693
            ..||     .|.|..:|.|..:.|.::...  |:|||                       |..|:
Zfish   875 SLDM-----NMPPKGAQGQYPMMRNNNPYS--IMQQQGMMGNHAVMPNQPNMVNAGVMGNNGPRV 932

  Fly   694 VSEQ-----------------------------LLLSRYT-------------------YLQPM- 709
            ..:|                             .|.||..                   .|||. 
Zfish   933 GMQQDGWGAQGTVGSAASPATAAPAGQHSLPQGALHSRMVPNPATGMPMRPNSQPGPRPMLQPQM 997

  Fly   710 -------MSMGF---------APGNMTA-----------AAVGNLGASGQRG------------- 734
                   |.||.         ||.|.||           ...||..:|...|             
Zfish   998 MANAQSNMDMGMAGHQFPQQQAPPNQTAPWPDSVMPIEPVPFGNQSSSMYGGSQEDVLCPPASEG 1062

  Fly   735 ---------------LNFTGSNAVQPQFNQYGFALNSEQMLNQ-----------QDQQMMMQQQQ 773
                           .:|.|...:..       ||....::.|           ||..|||.|:.
Zfish  1063 PADEGALLSQLYSALKDFDGLEEIDR-------ALGIPALVGQAQPVEQDQFPGQDPSMMMDQKP 1120

  Fly   774 NLHTQHQH-----NLQQQ----------HQSHSQLQQ---------------------------- 795
            .::.|.|:     |:||.          |....|:.|                            
Zfish  1121 PMYGQQQYASSPANMQQAGYTPMQDATFHGLQGQMGQRPGYPMLRMQARPGLRPGGVVPNQPNTL 1185

  Fly   796 HTQQQHQQQQQQQQQ--------------------------------QQQQQ-------QQQQQQ 821
            ..|.||:.|.||.:|                                |:|::       |:|..|
Zfish  1186 RLQLQHRLQAQQNRQPMMNQMGGVSNMNLPLRPNVPNQGTINAQMLAQRQRELLSNHLRQRQLDQ 1250

  Fly   822 QQQQQQQQQQQQQLQLQQQNDILLREDIDDIDAFLNLSPLHSL------GSQSTINPFNSSSNNN 880
            |:|||||||||:.|.::.|.              |.:.|..:.      |:.|  ||....:|..
Zfish  1251 QRQQQQQQQQQRSLAMRAQG--------------LTMPPNMAAAAAGMPGAMS--NPRIPQANLQ 1299

  Fly   881 NQSY--NGGSNLNNGNQNNNNRSSNPPQNNNEDSLLSCMQMATESSPSINFHMGISDDGSETQSE 943
            ...|  |.|:.|.:...:.:..|...| |.....|||...|........|..|..|..|......
Zfish  1300 QFPYPPNYGTGLASPPPSTSPFSPGSP-NLPAPQLLSHSAMHGSQMSLANQGMLGSLSGQFGAVM 1363

  Fly   944 DNKMMHTS----GSNLVQQQ-----------------QQQQQQQQILQQHQQQSNSFFSSNPFLN 987
            ..:|.|::    .|.:.||.                 :....|..::|  |.|.||.|.|:|.:|
Zfish  1364 SPQMQHSAFQFPSSGMSQQSDGGFGGAATPQSPLMSPRMGHAQSPMMQ--QAQGNSSFQSSPDMN 1426

  Fly   988 ---SQNQNQNQLPNDLEILPYQMSQEQSQNLFN 1017
               ..|.|.|.:.....  |.|.||:.:.|::|
Zfish  1427 GWPQGNINTNSMFTQQS--PPQFSQQANNNMYN 1457

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClkNP_001014576.1 HLH 16..68 CDD:238036 12/58 (21%)
PAS 93..153 CDD:214512 22/82 (27%)
PAS 264..366 CDD:238075 21/113 (19%)
PAS_11 265..368 CDD:291273 22/114 (19%)
ncoa2NP_571852.1 basic helix-loop-helix DNA-binding domain 18..86 15/77 (19%)
HLH 36..89 CDD:197674 13/64 (20%)
PAS 119..176 CDD:214512 21/56 (38%)
PAS A domain 125..184 18/58 (31%)
PAS_11 267..375 CDD:291273 21/110 (19%)
PAS B domain 269..330 14/63 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..515 27/124 (22%)
NCOA_u2 460..567 CDD:293270 21/109 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..562 3/20 (15%)
SRC-1 629..705 CDD:285981 7/75 (9%)
NR Box 630..634 1/3 (33%)
NR Box 686..690 1/3 (33%)
DUF4927 728..803 CDD:292896 6/74 (8%)
NR Box 742..746 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 835..871 10/36 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..962 0/22 (0%)
Nuc_rec_co-act 1061..1106 CDD:285967 5/51 (10%)
LLXXLXXXL motif. /evidence=ECO:0000255 1069..1077 0/7 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1246..1265 12/18 (67%)
HAT-like domain 1310..1378 14/68 (21%)
DUF1518 1354..1410 CDD:284808 8/55 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1475..1505
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3561
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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