Protein Alignment Clk and SIM2

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_005060.1
• Gene: SIM2 / 6493
• HGNCID: 10883
• Length: 667
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 122/545 - (22%)
• Similarity: 220/545 - (40%)
• Gaps: 126/545 - (23%)

  Fly    18 KSRNLSEKKRRDQFNSLVNDLSALI---STSSRKMDKSTVLKSTIAFLKNHNEATDRSKVFE--I 77
            ||:| :.|.||::.|....:|:.|:   |..:.::||:::::.|.::||       ...||.  :
Human     4 KSKN-AAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLK-------MRAVFPEGL 60

  Fly    78 QQDW-KPA------FLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTI 135
            ...| :|:      .::.:..:|| |::||||:.|.:|.|.|.|.||:.:..||....:|...:|
Human    61 GDAWGQPSRAGPLDGVAKELGSHL-LQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSI 124

  Fly   136 YDLAYEMDHEALLNIFMNPTPVIEP--RQTDISSSNQITFYTHL------RRGGMEKVDANAYEL 192
            |:..:..||:.:..:.....|:...  ::.:|..|    |:..:      |..|:   ..:.|::
Human   125 YEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERS----FFLRMKCVLAKRNAGL---TCSGYKV 182

  Fly   193 VKFVGYFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREM 257
            :...||.:                      :...:...:......:.:..|..|:...|..|.|:
Human   183 IHCSGYLK----------------------IRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEI 225

  Fly   258 SIIDPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQT 322
            .:.   ||.|..:.|::.|.:|||.|...:.||.|.:::..:.|.:.|..|:..:...|..|...
Human   226 KLY---SNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVK 287

  Fly   323 GEGKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKV---VSYAEVL----KDSRKEG 380
            |:..:.|||.|:|...|:|:|:...|.::..:|:|..:|..:.|   :.|.|:.    :.|..:.
Human   288 GQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKS 352

  Fly   381 QKSGNSNSITNNGSSKVIASTGTSSKSASATTTLRDFELSSQNLDST---LLGNSLASLGTETAA 442
            |.|..:...|:..:.|::....|..|:...|......:.||..:|..   .|||..||.....||
Human   353 QDSWRTALSTSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAA 417

  Fly   443 ---TSPAVDSS------------------------------PMWSASAVQPSGS-CQI------- 466
               ..|..:||                              ||..|...||.|| |::
Human   418 PPELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFLST 482

  Fly   467 ------------NPL--KTSRPASS 477
                        |||  .:|.||.:
Human   483 LPASGECQWHYANPLVPSSSSPAKN 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	19/79 (24%)
		PAS	93..153	CDD:214512	21/59 (36%)
		PAS_11	265..368	CDD:464214	30/105 (29%)
SIM2	NP_005060.1	bHLH_SF	1..74	CDD:469605	19/77 (25%)
		PAS	79..140	CDD:214512	21/61 (34%)
		PAS_11	91..194	CDD:464214	24/131 (18%)
		PAS_3	243..329	CDD:430001	25/85 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..389		5/32 (16%)
		SIM_C	358..660	CDD:461963	32/150 (21%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:14697214	367..386		4/18 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..428		5/18 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..520		3/8 (38%)