DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clk and Hif3a

DIOPT Version :9

Sequence 1:	NP_001014576.1	Gene:	Clk / 38872	FlyBaseID:	FBgn0023076	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001375441.1	Gene:	Hif3a / 64345	RGDID:	70332	Length:	664	Species:	Rattus norvegicus

Alignment Length:	732	Identity:	151/732 - (20%)
Similarity:	265/732 - (36%)	Gaps:	185/732 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KSRNLSEKKRRDQFNSLVNDLSALISTS---SRKMDKSTVLKSTIAFLKNHNEATDRSKVFEIQQ 79
            |||: :.:.||.|...::..|:..:..:   |..:||:::::.||::|:.|....        ..
  Rat    18 KSRD-AARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCA--------AG 73

  Fly    80 DWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTIYDLAYEMDH 144
            :|.......:......|::|:||:||.::.|.:.|.||:::..||....:|...:|:|..:..|.
  Rat    74 EWNQVGKEGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQ 138

  Fly   145 EALLNIFMNPTPVIEPRQTDISSSNQITF---YTHLRRGGMEKVDANAYELVKFVGYFRNDTNTS 206
            |.|.:. :.|.|.:..::::.::....:.   .|...||....:.|..::::...|:.|
  Rat   139 EELQDA-LTPRPSLSKKKSEAATGRHFSLRMKSTLTSRGRTLNLKAATWKVLHCSGHMR------ 196

  Fly   207 TGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNP----QLIREMSIIDPTSNE- 266
                      :...||      |.:|          .|:.|.:.|    .||.| :|..|.|.|
  Rat   197 ----------AYKPPA------QTSP----------AGSPRSEPPLQCLVLICE-AIPHPASLEP 234

  Fly   267 ------FTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGEG 325
                  |.|:||::.||.:.|.|...:.||.|.:::|.|.|:|.|..|.|::......|...|:.
  Rat   235 PLGRGAFLSRHSLDMKFTYCDERIAEVAGYSPDDLIGCSAYEYIHALDSDAVSRSIHTLLSKGQA 299

  Fly   326 KSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKEGQKSGNSNSIT 390
            .:..||||.:...::|.||...|.......:.:.::|.|.::|..|
  Rat   300 VTGQYRFLARTGGYLWTQTQATVVSGGRGPQSESIICVHFLISRVE------------------- 345

  Fly   391 NNGSSKVIAST----------GTSSKSASATTTLRDFELSSQNLDSTLLGNSL------------ 433
            .||....:..|          |||||..                   :.||||
  Rat   346 ENGVVLSLEQTEQHTRRPPQLGTSSKKG-------------------IPGNSLDPPAPRILAFLH 391

  Fly   434 ------ASLGTE---------TAATSPAVDSSPMWSASAVQPSGSCQINPLKTSRPAS----SYG 479
                  |||..:         ....:|.:|..|    :|..||     .|....||.|    ...
  Rat   392 PPALSEASLAADPRRFCSPDLRRLMAPILDGPP----TAATPS-----TPQAARRPQSPLPADLP 447

  Fly   480 NISSTGISPKAKRKCYFYNNRGNDSDSTSMSTDSVTSRQSMMT---------HVSSQSQRQRSHH 535
            :..:.|:. .|.|......|:..::| ..::.|..|....|:.         .::|..|..:.|.
  Rat   448 DQLAVGLE-NAHRLSTARKNKTMETD-LDIAQDPDTLDLEMLAPYISMDDDFQLNSSEQLPKVHR 510

  Fly   536 REHHRENH-HNQSHHHMQQQQQHQNQQQQHQQHQQLQQQLQHTVGTPKMVPLLPIASTQIMAGNA 599
            |....... ..:|.|.:...........:.....:|... ..:.|.|...||.|....:.:|.::
  Rat   511 RPPRTARRPRARSFHGLSPPIPEATLLPRWGSDPRLNCS-SSSKGDPPTAPLTPRTRKRALAQSS 574

  Fly   600 ----CQFPQPAYPLASPQLVAPTFLEPPQYLTAI------------PMQPVI---APFPVAPVLS 645
                .:..:...|..||:|...:.|.||..|:.:            |..|::   .|..:||.|.
  Rat   575 EDKGLELLETKPPKRSPRLEPGSVLLPPLSLSFLLQGRQLPGNQPDPRAPLVDSHEPLGLAPSLL 639

  Fly   646 PL-----PVQSQTDMLP 657
            .|     .:|.:...||
  Rat   640 SLYQHEETIQPRNHFLP 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	14/52 (27%)
		PAS	93..153	CDD:214512	18/59 (31%)
		PAS	264..366	CDD:238075	32/108 (30%)
		PAS_11	265..368	CDD:291273	31/109 (28%)
Hif3a	NP_001375441.1	bHLH-PAS_HIF3a_PASD7	12..74	CDD:381572	14/64 (22%)
		PAS	90..145	CDD:214512	18/55 (33%)
		PAS_3	251..338	CDD:369881	24/86 (28%)
		PHA03247	<360..633	CDD:223021	54/303 (18%)
		HIF-1	477..506	CDD:402842	5/28 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910