DRSC/TRiP Functional Genomics Resources

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Protein Alignment Clk and HIF3A

DIOPT Version :10

Sequence 1:NP_001014576.1 Gene:Clk / 38872 FlyBaseID:FBgn0023076 Length:1027 Species:Drosophila melanogaster
Sequence 2:XP_016882621.1 Gene:HIF3A / 64344 HGNCID:15825 Length:755 Species:Homo sapiens


Alignment Length:488 Identity:123/488 - (25%)
Similarity:203/488 - (41%) Gaps:73/488 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 KSRNLSEKKRRDQFNSLVNDLSALISTS---SRKMDKSTVLKSTIAFLKNHNEATDRSKVFEIQQ 79
            |||: :.:.||.|...::..|:..:..:   |..:||:::::.||::|:.|....        ..
Human    62 KSRD-AARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCA--------AG 117

  Fly    80 DWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTIYDLAYEMDH 144
            :|.......:......|::|:||:||.::.|.:.|.||:::..||....:|...:|:|..:..|.
Human   118 EWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQ 182

  Fly   145 EALLNIFMNPTPVIEPRQTDISSSNQITFYTHLRRGGMEKVDANAYEL-VKFVGYFRNDTNTSTG 208
            |.|.:       .:.|:||             |.|..:|......:.| :|.....|..|.....
Human   183 EELQD-------ALTPQQT-------------LSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKA 227

  Fly   209 SSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSIIDPTSNE------- 266
            ::.:|.|.|....|..|.. |.:|....|.:      ..:|...||.| :|..|.|.|       
Human   228 ATWKVLNCSGHMRAYKPPA-QTSPAGSPDSE------PPLQCLVLICE-AIPHPGSLEPPLGRGA 284

  Fly   267 FTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGEGKSCYYR 331
            |.|:||::.||.:.|.|...:.||.|.:::|.|.|:|.|..|.|::......|...|:..:..||
Human   285 FLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYR 349

  Fly   332 FLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAE----VL------KDSRKEGQKSGNS 386
            ||.:...::|.||...|.......:.:.:||.|.::|..|    ||      :.||:..|:...|
Human   350 FLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPS 414

  Fly   387 NSIT-NNGSS------KVIASTGTSSKS-ASATTTLRDFELSSQNLDSTLLGNSLASLGTETAAT 443
            ...| |.|.|      :::|.....|.| |:.....|.|  .|.:| ..|||..|.........:
Human   415 QKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRF--CSPDL-RRLLGPILDGASVAATPS 476

  Fly   444 SPAVDSSPMWSASAVQPS----GSCQINPLKTS 472
            :|.....|....||..|.    |:..::.|.||
Human   477 TPLATRHPQSPLSADLPDELPVGTENVHRLFTS 509

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClkNP_001014576.1 bHLH-PAS_dCLOCK 11..86 CDD:381578 15/70 (21%)
PAS 93..153 CDD:214512 18/59 (31%)
PAS_11 265..368 CDD:464214 32/109 (29%)
HIF3AXP_016882621.1 bHLH-PAS_HIF3a_PASD7 56..118 CDD:381572 14/64 (22%)
PAS 139..>214 CDD:238075 23/94 (24%)
PAS_11 285..392 CDD:464214 33/106 (31%)
PHA03247 <415..755 CDD:223021 25/98 (26%)
HIF-1 565..595 CDD:463274
Blue background indicates that the domain is not in the aligned region.

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