DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clk and arnt2

DIOPT Version :9

Sequence 1:	NP_001014576.1	Gene:	Clk / 38872	FlyBaseID:	FBgn0023076	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	XP_009301213.1	Gene:	arnt2 / 64277	ZFINID:	ZDB-GENE-001207-3	Length:	738	Species:	Danio rerio

Alignment Length:	689	Identity:	147/689 - (21%)
Similarity:	260/689 - (37%)	Gaps:	189/689 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DDESDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSS---RKMDKSTVLKSTIAFLK 63
            ||:....|  |....|::.:..|::||::....:.:||.::.|.|   ||.||.|:|:..::.:|
Zfish    67 DDDQIPGD--KERYARENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMK 129

  Fly    64 N----HNEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSS-MGSIFYASESITSQL 123
            :    .|.:||.:        :||:||:..|..||:||:.|||:.|.:: .|.:.|.|:|:|..|
Zfish   130 SMRGTGNTSTDGA--------YKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVL 186

  Fly   124 GYLPQDLYNMTIYDLAYEMDHEALLNIFMNPTPVIEPRQTDISS----------------SNQIT 172
            .:...:.:..|:::..:..|.:.|..........:..|..|:.:                .::.:
Zfish   187 NHPQSEWFGSTLFEQVHPDDVDKLREQLSTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRS 251

  Fly   173 FYTHLRRG-----------------------GMEKVDANAYELVKFVGYFR---------NDTNT 205
            |...:|.|                       |..|.....|.:|...||.:         .|.:|
Zfish   252 FICRMRCGSAPLDHISLNRLSSMRKRYRNGLGPSKEGEAQYSVVHCTGYIKAWPPAGMTIPDEDT 316

  Fly   206 STGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQ---NPQLIREMSIIDPTSNEF 267
            ..|.:|                           |...|..||:|   :|..:....:..||  ||
Zfish   317 EAGQTS---------------------------KYCLVAIGRLQVTSSPVSMDMNGLSVPT--EF 352

  Fly   268 TSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQT----GEGKSC 328
            .|:|:.:....|:|.|...:|||.|.::||....::.|.:|...:   .|..:|.    |:..|.
Zfish   353 LSRHNSDGIITFVDPRCINVIGYQPQDLLGKDILEFCHPEDQSHL---RESFQQVVKLKGQVLSV 414

  Fly   329 YYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAE-----VLKDSRKEGQKSGNSNS 388
            .|||..|.::|:.::|..:...:.::.:.:|::||:..|...:     .|:..:::|..:.:.:.
Zfish   415 MYRFRMKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQQAELEVHQRDGLTAYDLSQ 479

  Fly   389 ITNNGSSKVIASTGTS-SKSASATTTLRD---------FELSSQNL---DSTLLGNSLASLGT-- 438
            :..:|.|..:..:|.| .|:.|..:..||         ...|.:.:   .||..|..|.|.|:
Zfish   480 VPVSGVSAGVHESGKSIDKTESLFSQERDPRFSDIYTGISTSEKKMMVPSSTSGGQQLYSQGSPF 544

  Fly   439 ----------------------ETAATSPAVDSSPM----------WSASAVQPSGSCQINPLKT 471
                                  ::.|.|...:.|.:          ||.:....||..|| |.::
Zfish   545 QPGHSGKSFSSSVIHVPGVNDIQSTAGSAGQNLSQISRQINTGQVSWSGNRPPFSGQQQI-PAQS 608

  Fly   472 SR----------------PASSYGNISSTGISPKAKRKCYFYNNRGNDSDSTSMSTDSVTSRQSM 520
            ::                ..|||..:||...|..:........||....|.:..|:.|....|..
Zfish   609 NKAQSSPFGIGSSHSYQADPSSYSPLSSPATSSPSGNAYSNLANRNTAFDVSGESSQSGGQFQGR 673

  Fly   521 MTHVSSQSQRQRSHHREHHRENHHNQS----HHHMQQQQ 555
            .:.|.||.|.|           ||:|.    |.|.|..|
Zfish   674 PSEVWSQWQSQ-----------HHSQQAGDPHPHTQASQ 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	16/58 (28%)
		PAS	93..153	CDD:214512	17/60 (28%)
		PAS	264..366	CDD:238075	28/105 (27%)
		PAS_11	265..368	CDD:291273	28/106 (26%)
arnt2	XP_009301213.1	HLH	80..132	CDD:278439	15/51 (29%)
		PAS	152..258	CDD:279347	21/105 (20%)
		PAS	155..219	CDD:214512	17/63 (27%)
		PAS_11	351..451	CDD:291273	28/102 (27%)
		PAS	351..447	CDD:238075	26/98 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577650
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840