Protein Alignment Clk and NPAS3

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_016877071.1
• Gene: NPAS3 / 64067
• HGNCID: 19311
• Length: 986
• Species: Homo sapiens
• Alignment Length: 629
• Identity: 120/629 - (19%)
• Similarity: 241/629 - (38%)
• Gaps: 159/629 - (25%)

  Fly    18 KSRNLSEKKRRDQFNSLVNDLSALI---STSSRKMDKSTVLKSTIAFLKNHNEATDRSKVFEIQ- 78
            |||: :.:.||.:.|....:|:.|:   :..:.::||:::::.||::||..:.|......:.::
Human    91 KSRD-AARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRM 154

  Fly    79 ------------QDWK--------------------PAFLSNDEY-THL---MLESLDGFMMVFS 107
                        |.||                    |:.|:.:.: .||   :|:|||||:...:
Human   155 EGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALN 219

  Fly   108 SMGSIFYASESITSQLGYLPQDLYNMTIYDLAYEMDH-EALLNIFMNPTP--------VIEPRQT 163
            ..|...|.||:::..||....:|...:::|..:..|| |....:.|...|        ..|...:
Human   220 QEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGAS 284

  Fly   164 DISSSNQ--------------------------ITFYTHLRRGGMEKVDANAYELVKFVGYFRND 202
            ..|||:|                          |...:.|.:.|:. :.::.|:::...|..|..
Human   285 SASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVH-IKSSGYKVIHITGRLRLR 348

  Fly   203 TNTSTGSS--SEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSIIDPTSN 265
            .:.|.|.:  |::..                        ||.|  .....|..|.|:.|   ..:
Human   349 VSLSHGRTVPSQIMG------------------------LVVV--AHALPPPTINEVRI---DCH 384

  Fly   266 EFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGEGKSCYY 330
            .|.::.:|:...::.::|....:...|.:::|...|.:.|.:|::.|...|.:|...|:..:.||
Human   385 MFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYY 449

  Fly   331 RFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKE-------GQKSGNSNS 388
            |::.|...:||:|:...::.:..|:....::..:.::|..| .||:..:       .:|:..|:.
Human   450 RWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPE-YKDTPMDIAQLPHLPEKTSESSE 513

  Fly   389 ITNNGSSKVIASTGTSSKSASATTTLRDFELSSQNLDSTLLGNSLASLGTETAATSPAVDSSPMW 453
            .:::.|         .||..|..|.      .::|..|...||...:      :..|..|...
Human   514 TSDSES---------DSKDTSGITE------DNENSKSDEKGNQSEN------SEDPEPDRKK-- 555

  Fly   454 SASAVQPSGSCQINPLKTSRPASSYGNIS---STGISPKA-------------KRKCYFYNNRGN 502
            |.:|.....:|..:...:|.|.|...:.|   |...:|||             |.:.|.    .:
Human   556 SGNACDNDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYV----ES 616

  Fly   503 DSDSTSMSTDSVTSRQSMMTHVSSQSQRQRSHHREHHRENHHNQ 546
            :||....:.:|:||..:..:..:.::..|.|...:..::....|
Human   617 ESDLRLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQ 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	19/103 (18%)
		PAS	93..153	CDD:214512	19/63 (30%)
		PAS_11	265..368	CDD:464214	20/102 (20%)
NPAS3	XP_016877071.1	bHLH-PAS_NPAS3_PASD6	84..160	CDD:381575	15/69 (22%)
		PAS	205..263	CDD:214512	17/57 (30%)
		KinE	207..>466	CDD:444511	59/288 (20%)
		PAS_3	396..483	CDD:430001	18/86 (21%)
		MSCRAMM_ClfA	<489..>648	CDD:468110	35/186 (19%)