DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clk and Clock

DIOPT Version :9

Sequence 1:	NP_001014576.1	Gene:	Clk / 38872	FlyBaseID:	FBgn0023076	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001376183.1	Gene:	Clock / 60447	RGDID:	620271	Length:	864	Species:	Rattus norvegicus

Alignment Length:	982	Identity:	330/982 - (33%)
Similarity:	447/982 - (45%)	Gaps:	265/982 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ESDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSSRKMDKSTVLKSTIAFLKNHNEA 68
            |.||||..|    |.|||.||||||||||.|:.:|.:::..::|||||||||:.:|.||:.|.|.
  Rat    27 EEDDKDKAK----RVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHKEI 87

  Fly    69 TDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNM 133
            |.:|...||:|||||.||||:|:|.||||:||||.:...:.||:.|.||::||.|.:||.||.:.
  Rat    88 TAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSVVYVSETVTSLLEHLPSDLVDQ 152

  Fly   134 TIYDLAYEMDHEALLNIFMNPTPVIEP---RQTDISSSNQITFYTHLRRGGMEKVDANAYELVKF 195
            :|::...|.:|..:..|.  .|.::|.   ...|:.|.||:.|..|:.||.::..:.:.||.|:|
  Rat   153 SIFNFIPEGEHSEVYKIL--STHLLESDSLTPEDLKSKNQLEFCCHMLRGTIDPKEPSTYEYVRF 215

  Fly   196 VGYFR--NDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMS 258
            :|.|:  |..:|||      .||..|       ..|:......:.::.||.|.|:..||.|:||.
  Rat   216 IGNFKSLNSVSTST------HNGFEG-------TIQRTHRPSYEDRVCFVATVRLATPQFIKEMC 267

  Fly   259 IIDPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTG 323
            .::..:.||||:||:|||||||||||||||||:||||||||||||||.|||:|:..|||.|.|.|
  Rat   268 TVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLESLAKCHEHLMQYG 332

  Fly   324 EGKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKE--------- 379
            :||||||||||||||||||||.||::|||:||:|:::||||.|||||||..:.|:|
  Rat   333 KGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAERRRELGIEESLPE 397

  Fly   380 -----GQKSGNSNSI-------------------TNNGSSKVIASTGTSSKSASAT--------- 411
                 .|.||:.|.|                   .::.||:..:.|..|..|::.|
  Rat   398 TAADKSQDSGSDNRINTVSLKEALERFDHSPTPSASSRSSRKSSHTAVSDPSSTPTKIPTDTSTP 462

  Fly   412 ----------TTLRDFELSSQNLDSTLLGNSLASLGTETAATSPAVDSSPMWSASAVQPSGSCQI 466
                      .|.|....|||:::|..:|:||         |.||:..    :|:...|.|
  Rat   463 PRPHLPAHEKMTQRRSSFSSQSINSQSVGSSL---------TQPAMSQ----AANLPIPQG---- 510

  Fly   467 NPLKTSRPASSYGNISSTGISPKAKRKCYFYNNRGNDSDSTSMSTDSVTSRQSMMTHVSSQ-SQR 530
                                                      ||...::::...|.|:..| .||
  Rat   511 ------------------------------------------MSQFQLSAQLGAMQHLKDQLEQR 533

  Fly   531 QRSHHREHHRENHHNQSHHHMQQQQQHQNQQQQHQQH-QQLQQQLQHTVGTPKMVPLLPIASTQI 594
            .|......||           ||::..:.|:|....| |.||..||.:      .|.|...|.|:
  Rat   534 TRMIEANIHR-----------QQEELRKIQEQLQMVHGQGLQMFLQQS------NPGLNFGSVQL 581

  Fly   595 MAGNACQFPQPAYPLASPQLVAPTFLEPPQYLTAIPMQPVIAPFPVAPVLSPLPVQSQTDMLPDT 659
            .:||:                      ..|.||.|.||..:.|.
  Rat   582 SSGNS----------------------NIQQLTPINMQGQVVPV--------------------- 603

  Fly   660 VVMTPTQSQLQDQLQRKHDELQKLILQQQNELRIV----SEQLLLSRYTYLQPMMSMGFAPGNMT 720
                   :|:|..:...|....:.::|||. |:..    |:|.::|.::  ||.......|..:|
  Rat   604 -------NQIQSGVNAGHVSTGQHMIQQQT-LQSTSTQQSQQSVMSGHS--QPTSLPNQTPSTLT 658

  Fly   721 AAAVGNLGASGQRGLNFTGSNAVQPQFNQYGFALNSEQMLN----QQDQQMMMQQQQNLHTQ--- 778
            |.....:..|.....:.....:..||        ||.|...    .||:|:...|.|.|.|:
  Rat   659 APLYNTMVISQPAAGSMVPIPSSMPQ--------NSTQSATVTTFTQDRQIRFSQGQQLVTKLVT 715

  Fly   779 ----------------------HQHNLQQQHQSHSQLQQHTQQQHQQQQQQQQQQQQQQQQQQQQ 821
                                  :.....||.|  :|....||||.|||||||||||||.||.|.|
  Rat   716 APVACGAVMVPSTMLMGQVVTAYPTFATQQQQ--AQALSVTQQQQQQQQQQQQQQQQQPQQAQPQ 778

  Fly   822 QQQQQQQQQQ-----QQQLQLQQ------QNDILLREDIDDIDAFLNLSPLHSLGSQSTINPFNS 875
            .|.||..|.|     ||..||.|      |...||.   .:....|.||....| .|||..|.:.
  Rat   779 PQSQQSSQDQPHPSVQQPAQLTQPPQQFLQTSRLLH---GNPSTQLILSAAFPL-QQSTFPPSHH 839

  Fly   876 SSNNNNQ 882
            ..:...|
  Rat   840 QQHQQQQ 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	29/51 (57%)
		PAS	93..153	CDD:214512	24/59 (41%)
		PAS	264..366	CDD:238075	79/101 (78%)
		PAS_11	265..368	CDD:291273	80/102 (78%)
Clock	NP_001376183.1	bHLH-PAS_CLOCK	29..89	CDD:381577	35/63 (56%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O08785	32..47		10/18 (56%)
		PAS	109..202	CDD:395786	36/94 (38%)
		PAS_11	274..377	CDD:405306	80/102 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..497		22/117 (19%)
		Interaction with SIRT1. /evidence=ECO:0000250\|UniProtKB:O08785	450..570		36/189 (19%)
		Implicated in the circadian rhythmicity. /evidence=ECO:0000250	514..564		14/60 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	824..864		7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I2971
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1595
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002532
OrthoInspector	1	1.000	-	-		otm45836
orthoMCL	1	0.900	-	-		OOG6_105251
Panther	1	1.100	-	-	O	PTHR46055
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1900
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.960