Protein Alignment Clk and bmal2

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_571653.3
• Gene: bmal2 / 58099
• ZFINID: ZDB-GENE-000509-2
• Length: 631
• Species: Danio rerio
• Alignment Length: 540
• Identity: 149/540 - (27%)
• Similarity: 247/540 - (45%)
• Gaps: 89/540 - (16%)

  Fly     1 MDDE---SDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALIST---SSRKMDKSTVLKSTI 59
            |:|:   |:|....|....|:..:..||:|||:.|:|:::|:|:|.|   .|||:||.|||:..:
Zfish    72 MEDDAGRSEDDQHLKIKCIREPHSQIEKRRRDKMNNLIDELAAMIPTCNPMSRKLDKLTVLRMAV 136

  Fly    60 AFLKNHNEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFS-SMGSIFYASESITSQL 123
            ..||:...||...    .:.::|||||.:||..||:|.:.|||:.|.. ..|.|.:.|||::..|
Zfish   137 QHLKSLKGATSSF----AEANYKPAFLPDDELKHLVLRAADGFLFVVGCDRGKIVFVSESVSKTL 197

  Fly   124 GYLPQDLYNMTIYDLAYEMD---------------HEALLNI-----FMNPTPVIEPRQTDISSS 168
            .|...:|...:::|..:..|               .|.|::.     .....||...|   :.|.
Zfish   198 NYSRTELIGQSLFDYVHPKDIGKVKEQLSASELYPRERLIDAKTGLQVQAELPVGSAR---LCSG 259

  Fly   169 NQITFYTHLR-------------RGGMEKVDANAYELVKFVGYFRNDTNTSTGSSSEVSNGSNGQ 220
            .:.:|:..::             .|..:|.::..|..|...||.|........:..|
Zfish   260 ARRSFFCRMKYNKITVKEEKDFQAGASKKKESQRYCTVHCTGYMRTWPTRQLATEGE-------- 316

  Fly   221 PAVLPRIFQQNPNAEVDKK----LVFVGTGRVQN---PQLIREMSIIDPTSNEFTSKHSMEWKFL 278
                         ||.||:    ...|..|||..   ||...|:. :.||  ||.::::|:.||.
Zfish   317 -------------AEADKESSHFSCLVAMGRVHPHTLPQANGEIK-VKPT--EFVTRYAMDGKFT 365

  Fly   279 FLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGE--GKSCYYRFLTKGQQWIW 341
            |:|.||..|:||:|.|:||||.|:|:|.|||..:...|.::.::.|  ..:| |:|.||...::.
Zfish   366 FVDQRATTILGYLPQELLGTSCYEYFHLDDLPHLAERHRKVLRSKEKIETNC-YKFKTKSGSFVN 429

  Fly   342 LQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKEGQKSGNSNSITNNG--SSKVIASTGTS 404
            ||:.::...:.:..:.:|:|.|:.|||.......|..:.::..:|.:..::.  |.:|....|.|
Zfish   430 LQSQWFSFINPWTKEVEYIVSTNTVVSGKSNPGGSGDKAEQPSSSKASEDDAKKSQQVPIIPGIS 494

  Fly   405 SKSASATTTLRDFELSSQNLDSTLLGNSLASLGTETAATSPAVDSSP--MWSASAVQPSGSCQ-- 465
            |.|..........:::::.:|...: ||..|.| .|:..|...|.||  :..||:..|:|..:
Zfish   495 SASGMIYAGCIGTQIANEIMDFNRM-NSSPSSG-NTSPFSLLQDKSPLALAQASSNVPNGEAKDV 557

  Fly   466 INPLKTSRPASSYGNISSTG 485
            ..|.|:|....:.|...|||
Zfish   558 EMPGKSSSEEEARGGPFSTG 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	28/77 (36%)
		PAS	93..153	CDD:214512	19/80 (24%)
		PAS_11	265..368	CDD:464214	37/104 (36%)
bmal2	NP_571653.3	None