DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clk and arntl2

DIOPT Version :9

Sequence 1:	NP_001014576.1	Gene:	Clk / 38872	FlyBaseID:	FBgn0023076	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_571653.2	Gene:	arntl2 / 58099	ZFINID:	ZDB-GENE-000509-2	Length:	631	Species:	Danio rerio

Alignment Length:	540	Identity:	149/540 - (27%)
Similarity:	246/540 - (45%)	Gaps:	89/540 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDDE---SDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALIST---SSRKMDKSTVLKSTI 59
            |:|:   |:|....|....|:..:..||:|||:.|:|:::|:|:|.|   .|||:||.|||:..:
Zfish    72 MEDDAGRSEDDQHLKIKCIREPHSQIEKRRRDKMNNLIDELAAMIPTCNPMSRKLDKLTVLRMAV 136

  Fly    60 AFLKNHNEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFS-SMGSIFYASESITSQL 123
            ..||:...||...    .:.::|||||.:||..||:|.:.|||:.|.. ..|.|.:.|||::..|
Zfish   137 QHLKSLKGATSSF----AEANYKPAFLPDDELKHLVLRAADGFLFVVGCDRGKIVFVSESVSKTL 197

  Fly   124 GYLPQDLYNMTIYDLAYEMD---------------HEALLNI-----FMNPTPVIEPRQTDISSS 168
            .|...:|...:::|..:..|               .|.|::.     .....||...|   :.|.
Zfish   198 NYSRTELIGQSLFDYVHPKDIGKVKEQLSASELYPRERLIDAKTGLQVQAELPVGSAR---LCSG 259

  Fly   169 NQITFYTHLR-------------RGGMEKVDANAYELVKFVGYFRNDTNTSTGSSSEVSNGSNGQ 220
            .:.:|:..::             .|..:|.::..|..|...||.|........:..|
Zfish   260 ARRSFFCRMKYNKITVKEEKDFQAGASKKKESQRYCTVHCTGYMRTWPTRQLATEGE-------- 316

  Fly   221 PAVLPRIFQQNPNAEVDKK----LVFVGTGRVQN---PQLIREMSIIDPTSNEFTSKHSMEWKFL 278
                         ||.||:    ...|..|||..   ||...|:. :.||  ||.::::|:.||.
Zfish   317 -------------AEADKESSHFSCLVAMGRVHPHTLPQANGEIK-VKPT--EFVTRYAMDGKFT 365

  Fly   279 FLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGE--GKSCYYRFLTKGQQWIW 341
            |:|.||..|:||:|.|:||||.|:|:|.|||..:...|.::.::.|  ..:| |:|.||...::.
Zfish   366 FVDQRATTILGYLPQELLGTSCYEYFHLDDLPHLAERHRKVLRSKEKIETNC-YKFKTKSGSFVN 429

  Fly   342 LQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKEGQKSGNSNSITNNG--SSKVIASTGTS 404
            ||:.::...:.:..:.:|:|.|:.|||.......|..:.::..:|.:..::.  |.:|....|.|
Zfish   430 LQSQWFSFINPWTKEVEYIVSTNTVVSGKSNPGGSGDKAEQPSSSKASEDDAKKSQQVPIIPGIS 494

  Fly   405 SKSASATTTLRDFELSSQNLDSTLLGNSLASLGTETAATSPAVDSSP--MWSASAVQPSGSCQ-- 465
            |.|..........:::::.:|...: ||..|.| .|:..|...|.||  :..||:..|:|...
Zfish   495 SASGMIYAGCIGTQIANEIMDFNRM-NSSPSSG-NTSPFSLLQDKSPLALAQASSNVPNGEATDV 557

  Fly   466 INPLKTSRPASSYGNISSTG 485
            ..|.|:|....:.|...|||
Zfish   558 EMPGKSSSEEEARGGPFSTG 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	22/54 (41%)
		PAS	93..153	CDD:214512	19/80 (24%)
		PAS	264..366	CDD:238075	36/103 (35%)
		PAS_11	265..368	CDD:291273	37/104 (36%)
arntl2	NP_571653.2	HLH	91..143	CDD:306515	22/51 (43%)
		PAS	172..266	CDD:238075	21/96 (22%)
		PAS_3	353..456	CDD:330807	37/103 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577649
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840