DRSC/TRiP Functional Genomics Resources

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Protein Alignment Clk and ARNTL2

DIOPT Version :9

Sequence 1:NP_001014576.1 Gene:Clk / 38872 FlyBaseID:FBgn0023076 Length:1027 Species:Drosophila melanogaster
Sequence 2:NP_001381453.1 Gene:ARNTL2 / 56938 HGNCID:18984 Length:647 Species:Homo sapiens


Alignment Length:569 Identity:130/569 - (22%)
Similarity:244/569 - (42%) Gaps:119/569 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 DDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALI---STSSRKMDKSTVLKSTIAFLKNHNE 67
            |.:...|....|::.:.:||:|||:.|:|:.:|||:|   :..:||:||.|||:..:..|::...
Human   109 DGEHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKG 173

  Fly    68 ATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFS-SMGSIFYASESITSQLGYLPQDLY 131
            .|:.    .:..:::|:||.::|..||:|::.:||:.|.. ..|.|.:.|:|::..|.|....|.
Human   174 LTNS----YVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLT 234

  Fly   132 NMTIYDLAYEMDHEALLNIFMNPTPV-----------IEPRQTDISSSNQITFYTHLRRG----- 180
            ..:::|             |::|..|           |.||:..|.:...:..:::|..|     
Human   235 GQSLFD-------------FLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVY 286

  Fly   181 --------------------------GMEKVDANAYELVKFVGYFRNDTNTSTGSSSEVSNGSNG 219
                                      ..:|.:...:..:...||.|:......|...|       
Human   287 SGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEE------- 344

  Fly   220 QPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMS---IIDPTSNEFTSKHSMEWKFLFLD 281
                      :|...:.......|..||:| |.::.:.|   .:.||  ||.::.::..||:::|
Human   345 ----------RNSKKDNSNFTCLVAIGRLQ-PYIVPQNSGEINVKPT--EFITRFAVNGKFVYVD 396

  Fly   282 HRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGEG-KSCYYRFLTKGQQWIWLQTD 345
            .||..|:||:|.|:||||.|:|:|.||.:::...|:.:.|:.|. .:..|:|..|...::.|::.
Human   397 QRATAILGYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQ 461

  Fly   346 YYVSYHQFNSKPDYVVCTHKVV------SYAEVLKDSRKEGQKSGNSNSITNNGSSKVIASTGTS 404
            ::...:.:..:.:|:|..:.:|      ..|..|..|.:..::|...:.::..|     .||||.
Human   462 WFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQSSEESSRQSCMSVPG-----MSTGTV 521

  Fly   405 SKSASATTTLRDFELSSQNLDST--LLGNSLASLGTETAATSPAVDSSPMWSASAVQPSGSCQIN 467
            ..:.|..|.:.:..|..|.|.|:  |..:|...|..:|    ..|:...|.:.....||.| ::.
Human   522 LGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLMKDT----HTVNCRSMSNKELFPPSPS-EMG 581

  Fly   468 PLKTSR------PASSYGNISSTGISPKAKRKCYFYNNRGNDSDSTSMS 510
            .|:.:|      ...|:..:.|.|........|        |:|.|:|:
Human   582 ELEATRQNQSTVAVHSHEPLLSDGAQLDFDALC--------DNDDTAMA 622

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClkNP_001014576.1 HLH 16..68 CDD:238036 20/54 (37%)
PAS 93..153 CDD:214512 15/60 (25%)
PAS 264..366 CDD:238075 30/102 (29%)
PAS_11 265..368 CDD:291273 31/109 (28%)
ARNTL2NP_001381453.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..73
Interaction with PER2. /evidence=ECO:0000250|UniProtKB:Q2VPD4 57..269 48/176 (27%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9WTL8 60..65
bHLH-PAS_ARNTL2_PASD9 119..178 CDD:381475 21/62 (34%)
Nuclear export signal 1. /evidence=ECO:0000250|UniProtKB:Q9WTL8 188..198 4/9 (44%)
PAS 203..298 CDD:238075 20/107 (19%)
PAS_11 381..483 CDD:405306 30/101 (30%)
Nuclear export signal 2. /evidence=ECO:0000250|UniProtKB:Q9WTL8 403..411 4/7 (57%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144525
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3561
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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