Protein Alignment Clk and epas1a

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_695262.7
• Gene: epas1a / 566886
• ZFINID: ZDB-GENE-030131-4490
• Length: 843
• Species: Danio rerio
• Alignment Length: 904
• Identity: 176/904 - (19%)
• Similarity: 331/904 - (36%)
• Gaps: 243/904 - (26%)

  Fly    16 CRKSRNLSEKKRRDQFNSLVNDLSALISTSSRKMDKSTVLKSTIAFLKNHNEATDRSKVFEIQQD 80
            ||:|      |..:.|..|.:.|....|.||. :||:::::..|:||:.....:....|.:::..
Zfish    25 CRRS------KETEVFYELAHQLPLPHSISSH-LDKASIMRLAISFLRTRKLFSSGQTVQQMRSQ 82

  Fly    81 WKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTIYDLAYEMDHE 145
                  :..:..:|.|:||:||::|.:|.|.:.:.||:::..:|....:|...:|:|..:..|||
Zfish    83 ------NGSQMDNLYLKSLEGFVIVVTSDGDMIFLSENVSKFMGLTQVELTGHSIFDFTHPCDHE 141

  Fly   146 ALL-NIFMNPTPVIEPRQTDISSSNQITFYTHLR-----RGGMEKVDANAYELVKFVGYFRNDTN 204
            .:. |:.:...||...:..::|:|..  |:..::     ||....:.:.:::::...|:.:
Zfish   142 EIRENLSIKSGPVYSRKGKEMSTSRD--FFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLQ---- 200

  Fly   205 TSTGSSSEVSNGSNGQP--------AVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSIID 261
            ..:....::..|.:..|        |.:|.  ..|.:..:|.|
Zfish   201 VCSSRPPQILCGFSEPPLTCITMLCAPIPH--PSNVDTPLDSK---------------------- 241

  Fly   262 PTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGEGK 326
                .|.|:|||:.||::.|.|...:|||.|.|:||.|.|::.|..|.:::...|:.|...|:..
Zfish   242 ----TFMSRHSMDMKFIYCDERVSSLIGYRPEELLGRSVYEFCHALDSENMTKSHQNLCNKGQVV 302

  Fly   327 SCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKEGQKSGNSNSITN 391
            |..||.|.|...::|::|...|.|:..||:|..::|.:.::|..|.........|..........
Zfish   303 SGQYRMLAKNGGYVWVETQATVIYNNRNSQPQCIICINYILSSVEEQSVIFSLDQTEALFKPYHT 367

  Fly   392 NGSSKVIA-STGTSSKSASATTTLR--------------------DFELSSQNLDSTLLGNS--L 433
            ....::.: :|..|....:..|||:                    ||| .::..::|....|  |
Zfish   368 YDMGEIFSQNTSISEPQNNLFTTLKEEPEELAQLAPMPGDAIIALDFE-RAEFEEATFFSKSSKL 431

  Fly   434 ASLGTETAATSPAVDSSPMWSASA---------VQPSGSCQINPLKTSRPASSYGNISSTGISP- 488
            .::|......:|. |.||..:.|:         |.|:|.|  .|..|  |..|..:..||..||
Zfish   432 PAVGPSWVVDTPP-DGSPERNLSSLPSSFTVPQVPPAGKC--TPCTT--PCLSSCSSCSTPSSPV 491

  Fly   489 ----------KAK-RKCYFYNNRGNDSDSTSMSTDSVTSRQSMMTHVSSQSQRQRSH-------- 534
                      |.: .:..|.:..|..:.:.|....|....:::..::....:..:.|
Zfish   492 DCCGSGEWDLKVELTEKLFASESGATNPTDSQLNLSDLDLETLAPYIPMDGEDFQLHPICLEEPV 556

  Fly   535 ------------HR------------EHHRENHHNQS----HHHMQQQQQHQN--------QQQQ 563
                        |.            ::...|.:..|    ..|:|..|...|        :|..
Zfish   557 PDAGPGLSAAVQHSFSSVADLFQPLGQYPPYNKNRPSTCPDATHIQPYQTTPNIPLSSEKQRQSL 621

  Fly   564 HQQHQQLQQQLQHT---------VGTPKMVPLLPIASTQIMAGNACQFPQPAYPLASPQLVAPTF 619
            |....|| .|.:||         .|.|               |.||.|..|
Zfish   622 HWPPDQL-SQYEHTNVGCMDDRNTGGP---------------GQACNFNVP-------------- 656

  Fly   620 LEPPQ---YLTAIPMQPVI----------------APFPVAPVLSPLPVQSQTDMLPDTVVMTPT 665
              ||.   :....|:|..:                :.||::...|.:|.|          |:.|.
Zfish   657 --PPHQRFFENFTPVQKGMSLGQRALLNNFKRKRQSEFPLSCSFSDIPKQ----------VVAPH 709

  Fly   666 QSQ--LQDQLQRKHDELQKLILQQQNELRIVSEQLLLSRYTYLQPM---MSMGFAPGNMTAAAVG 725
            :|.  ::.:::..:|:.....:::.....:::::....:...:.|.   .|:...|.::......
Zfish   710 KSTDGMRKRMKPMNDDSCAFSVRKSLSTSVLTDKFPCMQSGLVDPQACSRSVKGCPEDLKQHCTD 774

  Fly   726 NLGASGQRGLNF------TG--SNAVQPQFNQYGFALNSEQMLNQQDQQMMMQQQQNLH 776
            :..::..|..|.      ||  |..:.|.|:.|..     ..|.:.|.::.|..|.|||
Zfish   775 SFCSNSSRQYNMMPSRKHTGMISQLLAPSFDSYCL-----PELTRYDCEVNMPLQGNLH 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	16/69 (23%)
		PAS	93..153	CDD:214512	19/60 (32%)
		PAS_11	265..368	CDD:464214	36/102 (35%)
epas1a	XP_695262.7	None