Protein Alignment Clk and tai

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_061516117.1
• Gene: tai / 5668285
• VectorBaseID: AGAMI1_010623
• Length: 2038
• Species: Anopheles gambiae
• Alignment Length: 1660
• Identity: 303/1660 - (18%)
• Similarity: 459/1660 - (27%)
• Gaps: 719/1660 - (43%)

  Fly     8 KDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALI----STSSRKMDKSTVLKSTIAFLK----- 63
            |.|.|....:.::..:||:||:..|..:..|...:    ..::.|.||:.:|...:...:
Mosquito   148 KPDAKQPQSQINKCNNEKRRRELENEYIEQLGEFLQIKRDMTACKPDKAAILSEVVRTFRHMLEQ 212

  Fly    64 -NHN-----------EATDRSKVFEIQQDW---------KPAFLSNDEYTHLMLESLDGF----- 102
             |.|           :.:...|:..:||..         :|:...:........|::..:
Mosquito   213 GNPNLTGSRCSKCSPDCSASCKLHPVQQGEVSSTEPPLPEPSVNGHSPEKSAYFEAVQHYISNVG 277

  Fly   103 --MMVFSSMGSIFYASESITSQLGYLPQDLYNMTIYDLAYEMDHEALLNIFMNPTPVIEPRQTDI 165
              ::..:|.|.|..|:|::...|.|...:|:..:||...:..||..|       :|::.....::
Mosquito   278 WALLEINSEGVIECATENVRDVLHYSRTELHGQSIYSYLHTGDHSKL-------SPILNKNSFEL 335

  Fly   166 SSSNQITFY--------THLR------RGGMEKVDANAYELVKFVGYF------RNDTNTSTGSS 210
            :......||        |.:|      .|..|.::.....|.|:....      ::||..|:...
Mosquito   336 NWDQNEMFYQTPKRTIRTKIRWLLRAPEGANETIEQKQQRLEKYKDLLIISAPVKDDTEESSSVL 400

  Fly   211 SEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSIIDPTSNEFTSKHSMEW 275
            ..::...:.|..:......|..:.::..||...|             :|||..|:....:.:
Mosquito   401 CLITLPEDDQATIETTTMPQTLDEQLTLKLDTSG-------------NIIDYNSSTLRKQFA--- 449

  Fly   276 KFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEEL----RQTGEGKSCYYRFLTKG 336
                         |.:..|.: .|.||..|:.|...:   :|.|    ...|......||....|
Mosquito   450 -------------GNLTKESI-RSIYDLCHYQDRPRL---NEHLGNVRSSNGTPHELTYRLRLGG 497

  Fly   337 QQWIWLQTDYYVSYHQFN-----SKP---DYVVCTHKVVSYAEVLKDSRKEGQKS---GNSNS-- 388
                   .|.||.....:     :||   |:::....|::..||...|...|..:   |.|:|
Mosquito   498 -------PDVYVHVKTQSKLFRCTKPNETDFIMAICTVLTENEVAMLSADSGAMAMGVGGSSSGG 555

  Fly   389 ---------ITNNGSSKVIASTGTSSKSA------SATTTLRDFELSSQN--------------- 423
                     |.||..:...:|..|||.|:      |.:.|:....|:..|
Mosquito   556 LSAAMSGSNINNNNGNSSSSSNPTSSSSSLGLLMPSTSGTVTGGGLNGSNDVVARHMAQITQGVS 620

  Fly   424 ------LDSTLLGNSLASLGTETAAT--------------------------------------- 443
                  :.|.|.|...:::||.:.|:
Mosquito   621 NMGGPLMSSVLNGGGGSTVGTGSNASGMLGGGGMTGGSMSVAGGGMAGPGGTTPGSAGGSGLGGG 685

  Fly   444 ----------------------------------SPAVDSSPMWSA-------------SAV--- 458
                                              .|..|||..::.             .||
Mosquito   686 GGMGAGAGGMGPSAGSMGSIVSPRSNPNSSSLLCGPNSDSSNFFNTEFELDFPHSTFDMEAVGVG 750

  Fly   459 ---QPSGSCQINPLKTSRPASSYGNISSTGISPKAKRKC------YF------------------ 496
               :|.....:.|:.|.||.      |.:..||.|...|      |:
Mosquito   751 WDSRPDSRTSVTPVSTPRPP------SVSAYSPAAAPMCASPMTPYYSGSTMGGMPSPSNNNNNG 809

  Fly   497 -----------------------YNNRGNDSDSTSMST------------DSVTSRQSMMTHVSS 526
                                   .||..|::::.:..|            ||....|.:..  ..
Mosquito   810 VPGGGGGGSSGSSGGGLMNPSLSLNNNNNNTNNNNTGTPFGTNAFQFPFEDSKDKLQDLQQ--QQ 872

  Fly   527 QSQRQRSHHREH------HRENHHNQSHHHMQQQQQHQNQQQQHQQHQQLQQQLQHTVGTPKMVP 585
            |.|:|:.||..|      |:.....|....:|:||.||.||||....|.||||.|....|.....
Mosquito   873 QQQQQQQHHHPHMSPMQQHQSAMSAQQQQMVQRQQHHQQQQQQQHLQQHLQQQSQPPSNTHDSER 937

  Fly   586 LLPIASTQIMAGNACQFP--QPAYPLASPQLVAPTFLEPPQ--------YLTAIPMQPVIAPFPV 640
            |..:.:|:....||....  ...:...:|..:....|...:        ..||...|.:
Mosquito   938 LRNLLTTKRPHSNASSSSGLDMDHDHRNPNRILKGLLNSEEDKDTNGNKLSTASLSQRI------ 996

  Fly   641 APVLSPLPVQSQT-----------------------------------DMLPDTVVMTPTQ---- 666
                 |..|::.|                                   .:|.|......:.
Mosquito   997 -----PQSVRASTQGSNNGGGGGGVSGLGLATRAGNETNKSGSNNMLLQLLNDKSDDDESDARNR 1056

  Fly   667 ---SQLQDQLQRKHDE--------------LQKLILQQQNELRIVSE--------------QLLL 700
               |:|..|||:..||              :|.|.:|..:..|..:|              ..|.
Mosquito  1057 QGPSELLKQLQKVKDEPKEHNPPPLNNEELIQMLRVQSNDRKRPSTEPDEGAAVKRTDNRPSKLR 1121

  Fly   701 SRYTYL---------QPMMSMGFAPGNMTAAAVGNLGASGQRGLNFTGSNAVQPQFNQYGFA--- 753
            .|...|         .||......|.|.....:.|.|.:.|. .|.:.|.|.....|.....
Mosquito  1122 ERNKMLASLLANPAKAPMPMQTAMPFNRIIPDIPNSGLARQL-TNVSSSTAPNQTLNNNNLTTSN 1185

  Fly   754 --LNSEQMLN----QQDQQMMMQQQQNL-----------------------HTQHQHNLQQQHQS 789
              |...|.||    ||.||...||||.:                       ..|.||:.||..|:
Mosquito  1186 NNLKQVQQLNQMRLQQQQQQQQQQQQQMRKSAMPSQSQQPPTSSDIYLNHQQQQQQHHHQQHPQT 1250

  Fly   790 HSQ-LQQHTQQQHQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQL-----------------Q 836
            |.| ||||..||||||...|....||||....|:||......|...:                 |
Mosquito  1251 HPQHLQQHHAQQHQQQHHAQASMLQQQQMLAAQRQQNFSPAIQDAGIGSAGGGSFATATPATSTQ 1315

  Fly   837 LQQQNDILLREDID--------------DIDAFLNLSPLHS-----LGSQSTINP---------- 872
            |..:.|..|.|.::              ::::.|.|||:.|     :.|||:..|
Mosquito  1316 LVSEWDPELNEILNHVIEIAPEGDFAESELNSILGLSPIESSTSSVVPSQSSTQPDIHEKLAINA 1380

  Fly   873 --------------------------------------FNSSSNNNNQSYNGGS----------- 888
                                                  .|||.:....|..||.
Mosquito  1381 IQKSLMQYENVSSPLQPQPQPQFSGSPPAYPMHSMAGGANSSGSGAGSSGGGGGGGGGGGGMSGV 1445

  Fly   889 ----------------NLNNG-----------NQN---------------------NN------- 898
                            .:|:|           |||                     ||
Mosquito  1446 GPTGSGPGSSGGTGGPGMNSGSSGMQSSQAGPNQNFTPPPVYTQRMRIPQGQLGGGNNPGVPQNL 1510

  Fly   899 ------------------------------------NRSSN----PPQ------NNNEDSLL--- 914
                                                |.::|    ||.      ||..||.|
Mosquito  1511 LAMQKLQHQSRDRILQEQQRTRLLQQQQKQQMVVTVNSAANADLGPPNVTLTRANNVPDSQLSPG 1575

  Fly   915 ---SCMQMATESSPSINFHMGISDDGSETQSEDNKMMH--------------TSGSNL------- 955
               |.||.  :.|||....:.....|.:....:|...|              .:|.|:
Mosquito  1576 FSPSLMQQ--QLSPSQRTQLSPQQAGFQGNPFNNNPGHRLSPQLQQMVSGFGNAGGNVNQQLSPR 1638

  Fly   956 ----------------------------VQQQQQQQQQQQILQQHQQQSNSFFS---SNPFLNSQ 989
                                        .|||||||||||..||.||.:|:..|   .||.||:|
Mosquito  1639 QPPFGGGVGGPAVNQPNVVVPGQSPQQQQQQQQQQQQQQQQQQQWQQNANARLSIQQQNPMLNAQ 1703

  Fly   990 NQNQ---NQLPNDLEILPYQMSQEQSQNLFNSPHT 1021
            ..:.   |...|...:.|.|    :.:...|||.|
Mosquito  1704 LSSVGGFNPAANRQFVGPPQ----RQRGTLNSPGT 1734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	17/104 (16%)
		PAS	93..153	CDD:214512	14/66 (21%)
		PAS_11	265..368	CDD:464214	20/114 (18%)
tai	XP_061516117.1	None