Protein Alignment Clk and ncoa1

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_691744.6
• Gene: ncoa1 / 563288
• ZFINID: ZDB-GENE-041001-175
• Length: 1350
• Species: Danio rerio
• Alignment Length: 1348
• Identity: 256/1348 - (18%)
• Similarity: 401/1348 - (29%)
• Gaps: 478/1348 - (35%)

  Fly    16 CRKSRNLSEKKRRDQFNSLVNDLSALISTS-------SRKMDKSTVLKSTI-------------A 60
            |..|....||:||:.....:::|:.|:|.:       :.|.||..:||||:             |
Zfish    27 CDTSGPSVEKRRRELECRYIDELAELLSANMSDIASLNVKPDKCHILKSTVDQIQQIKRREQENA 91

  Fly    61 FLKNHNEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGY 125
            .|.:.|:...:|.:.....    ..:..:....|:||:||||..|.:..|.|.:.||::|..|||
Zfish    92 ALMSPNDEVQQSDISSSSH----GMVEKEALGPLLLEALDGFFFVVNREGRIVFVSENVTGYLGY 152

  Fly   126 LPQDLYNMTIYDLAYEMDHEALLNIFMNPTPVIE--PRQTDISSSNQITFYTHLRRGGMEKVDA- 187
            ..::|...::|.:.:..||...:.|.: |..::.  |...:....|..||...|.:...::||:
Zfish   153 TQEELMTSSVYSILHVGDHNEFVRILL-PKSLVNGVPWSQEQGRRNSHTFNCRLLKRPPDEVDSE 216

  Fly   188 -----NAYELVKFVGYFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGR 247
                 ..|||::..                    :..||..|     |....::...|:.:....
Zfish   217 NQEARQQYELMQCF--------------------TVSQPKAL-----QEEGEDLQSCLICIACRI 256

  Fly   248 VQNPQLIREMSIIDPTSNE-FTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYD------YYH 305
            .:.||:        |.|.| |.:|.....|.:.::..|        ....|..|::      .|.
Zfish   257 PRPPQI--------PVSTESFITKQDPTGKIISIETSA--------LRATGRPGWEDLVRKCIYA 305

  Fly   306 FDDLDSIVACH-----EELRQTGEGKSCYYRFLTKGQQWIWLQT-------------DYYVSYHQ 352
            |.........|     .|:...|...|..|||.......:..||             .:.:.:|.
Zfish   306 FFQPQGNEPSHAKKLLHEVMTHGMAISPLYRFTLSDGTSLSAQTRCKFCCPQNPDVQPFIMGFHT 370

  Fly   353 FNSKPDYVVCTHKVVSYAE---------VLKDSRKEGQKSGNSNSITNNGSSKVIASTGTSSKSA 408
            .:.:       |...|..|         ....||....:..:..||..|.::...|:.|..:.:.
Zfish   371 IDRE-------HNTASSQENTTPSLSSPAAPPSRSPALQPSSDLSIHLNNTNGTCATPGPLTPTP 428

  Fly   409 SATTTLRDFELSSQNLDSTLLGNSLASL-----------GTETAATSPAVDSSPM--WSASAVQP 460
            ....|......|.|....:.||:.|.:.           |:...|:||.|...|.  .:.|...|
Zfish   429 PGYLTPSRVGPSQQVSSPSPLGSPLTATPTSFMSPRPPRGSPGLASSPRVPGHPFSPSTPSIHSP 493

  Fly   461 SGS----------------CQINPLKTSRPASSYGN------ISSTGISPKAKRKCYFYNNRGND 503
            :|.                ..:.|.:|..|:||...      ..::...||:       |..||.
Zfish   494 AGGLTRQQSGGDGVGFSLPSPLPPRQTPTPSSSPARQPPAKPPEASNDEPKS-------NQVGNP 551

  Fly   504 SDSTSMSTDSVTSRQSMMTHVSSQSQRQRSHHREHHRENHHNQSHHHMQQQQQHQNQQQ------ 562
            ..|..:...|...:.| ....|..||...||.....|   |...|..:|........::
Zfish   552 KLSQLLDGASAPEQDS-QPRPSPTSQCPASHSSLTER---HKILHRLLQDNSPADAGKEPDIKKE 612

  Fly   563 ----------------QHQQHQQLQQQLQ-----------------HTV---------------- 578
                            :.|.||.|:..|.                 .||
Zfish   613 PPTSPNSALIARGLGKEPQDHQLLRFLLDTDEKDLEDLPPPATLSLQTVKVKAEKKGSRENVSCA 677

  Fly   579 ---------GTP----KMVP------------LLPIASTQI----------------------MA 596
                     |:|    |..|            |||.....:                      ..
Zfish   678 AALANNAMPGSPQSSGKASPQFPSTDLDTLNQLLPTLRASVGGKTVEEPSEDSLSIGVNVKRESP 742

  Fly   597 GNACQ-FP-------------------------------------QPAYPLASPQLVAPTF---- 619
            |.:.| ||                                     ||....:|| ..:||.
Zfish   743 GTSSQAFPDGENLSSQTSFDFCDPSTPNQGQSQVQVSDLGQTELFQPPKESSSP-FASPTSHNSF 806

  Fly   620 --------LEPP--QYLTAIPM-QPV-----IAPFPVAPVLSPLPVQSQTDMLP-DTVVMTPTQS 667
                    ||.|  |...|:|: :|:     :|....||:.||   |.|....| |.::..||..
Zfish   807 NTNTGLAKLELPDSQQFQALPLVEPMTFDNSLANQTQAPLSSP---QEQCVPCPLDEMLCPPTTP 868

  Fly   668 QLQDQLQRKHDELQKLILQQ---------QNELRIVSEQLLLSRYTY---LQPMMSMGF------ 714
                  :.::||  |.:|:|         ::||..:...|.:.:...   |:|:....|
Zfish   869 ------EGRNDE--KALLEQLVTFLSHTDESELAELDRALGIDKIVQSGCLEPVTQTPFPQSQPP 925

  Fly   715 ------------------APGNMTAAAVGNLGAS-GQRGLNFTGSNAVQPQFNQYGFALNSEQML 760
                              :|....|......|.| |...:.|.| |.||...|:   |......|
Zfish   926 TPVPLDPKLPSYPSQFPTSPSQFPAEMATAQGMSFGAPRMPFPG-NVVQAGMNR---APGVSNQL 986

  Fly   761 NQQDQQMMMQQQQNLHTQHQHNLQQQHQSHSQLQQ--HTQQ-QHQQQQQQQQQQQQQQQQQQQQQ 822
            .....|:.:|.||.|  |....||.:..:.....|  |... ..|..||.|...|.....|...|
Zfish   987 RLPPNQLRLQLQQRL--QGPQQLQNRLAAMGSFPQGGHVAMGMRQSIQQPQMPSQPPLNAQMMAQ 1049

  Fly   823 QQQQQQQQQQQQLQLQQQNDILLREDIDDIDAFLNLSPLHSLGSQSTINPFNSSSNNNNQSYNGG 887
            :|::....|.:|.||.||..:|:|:.|       |..||                        |.
Zfish  1050 RQREVYSYQHRQRQLLQQKVMLMRQGI-------NTGPL------------------------GA 1083

  Fly   888 SNLNNGNQNNNNRSSNPPQNNNEDSL---LSCMQMATESSPS------------INFHMGISDDG 937
            ..|..|.|....:.  |||...:...   .:.:...|.:|||            ::...|:.:.|
Zfish  1084 QRLPKGPQQQQQQP--PPQQQQQFGFPPGYNAVPGNTPTSPSHFNPMGGPLDPKLSVRAGLGNQG 1146

  Fly   938 ------------SETQSEDNKMMHTSGSNLVQQ-----------------QQQQQQQQQILQQHQ 973
                        ..|..:........||.::||                 .|....|..:|||.|
Zfish  1147 IMGAIQGQFGGPVNTPVQQGLFQQFGGSGMIQQADPSFAPELSPTSPLLSPQNSTSQSPLLQQTQ 1211

  Fly   974 -------------QQSNSFFSSNPFLN------SQNQNQNQLPNDLEI 1002
                         ||..  .::|...|      ||:..|..:.|::.|
Zfish  1212 PPPGYQSPDLKTWQQGT--VANNGMYNQVGPPVSQSFGQQGVYNNMSI 1257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	20/89 (22%)
		PAS	93..153	CDD:214512	21/59 (36%)
		PAS_11	265..368	CDD:464214	20/127 (16%)
ncoa1	XP_691744.6	None