DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clk and NPAS2

DIOPT Version :9

Sequence 1:	NP_001014576.1	Gene:	Clk / 38872	FlyBaseID:	FBgn0023076	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	XP_005264010.1	Gene:	NPAS2 / 4862	HGNCID:	7895	Length:	889	Species:	Homo sapiens

Alignment Length:	938	Identity:	306/938 - (32%)
Similarity:	434/938 - (46%)	Gaps:	250/938 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDDESDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSSRKMDKSTVLKSTIAFLKNH 65
            ||:  |:||..|    |.|||.||||||||||.|:.:||:::..::|||||:|||:..|.||:.|
Human    66 MDE--DEKDRAK----RASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKH 124

  Fly    66 NEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDL 130
            ||.:.::::.:|||||||:||||:|:|.||||:||||::..::.|||.|.|:|||..||:||.|:
Human   125 NEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGHLPSDV 189

  Fly   131 YNMTIYDLAYEMDHEALLNIFMNPTPVIE-PRQTDISSSNQITFYTHLRRGGMEKVDANAYELVK 194
            .:..:.:...|.:|..:..|..:...|.: |....:.|.:.:.||.||.||.:...:...||.:|
Human   190 MDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLLRGSLNPKEFPTYEYIK 254

  Fly   195 FVGYFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSI 259
            |||.||:..|..:.|.:...| :..:|..:|          :.|::.|:.|.|:..||.::||.|
Human   255 FVGNFRSYNNVPSPSCNGFDN-TLSRPCRVP----------LGKEVCFIATVRLATPQFLKEMCI 308

  Fly   260 IDPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGE 324
            :|....||||:||:|||||||||||||||||:||||||||||||||.|||:.:..||:.|.|.|:
Human   309 VDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGK 373

  Fly   325 GKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKE------GQKS 383
            ||||.|||||||||||||||.||::|||:||||:::||||.|||||:|..:.|:|      ..::
Human   374 GKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPSEA 438

  Fly   384 GNSNSITNNGSS---------------------KVIASTGTSSKSA-------SATTTLRDFELS 420
            .:|:::.:.|||                     ...||:.:|.||:       ::|.|....|.|
Human   439 LHSSALKDKGSSLEPRQHFNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEAS 503

  Fly   421 SQNLD-STLLGNSLASLGTETAATSPAVDSSPMWSASAVQPSGSC----QINP--LKTSRPASSY 478
            :..|. |..|...|...|...|||.||...||          .||    |:.|  :..|.||
Human   504 TPALPRSATLPQELPVPGLSQAATMPAPLPSP----------SSCDLTQQLLPQTVLQSTPA--- 555

  Fly   479 GNISSTGISPKAKRKCYFYNNRGNDSDSTSMSTDSVTSRQSMMTHVSSQ-SQRQRSHHREHHREN 542
                     |.|:....|                      ||...:..| .||.|.
Human   556 ---------PMAQFSAQF----------------------SMFQTIKDQLEQRTRI--------- 580

  Fly   543 HHNQSHHHMQQQQQHQNQQQ----------------------QHQQHQQLQQQLQH---TVGTPK 582
              .|::...||::.|:.|:|                      ...|..:.|||||.   .|..|:
Human   581 --LQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQPAVSLSFSSTQRPEAQQQLQQRSAAVTQPQ 643

  Fly   583 M--VPLLP--IASTQIMAGN--------ACQFPQPAYPLASPQLVAPTFLEPPQYLTAIPMQ--- 632
            :  .|.||  |:|.|:.:.:        :.|.|:   |:.|.||                ||
Human   644 LGAGPQLPGQISSAQVTSQHLLRESSVISTQGPK---PMRSSQL----------------MQSSG 689

  Fly   633 ----PVIAPFPVAPVLSPLPVQSQTDMLPDTVVMTPTQSQLQDQLQRK------HDELQKLILQQ 687
                .:::||           .|.|..||.::.:|...|..||..|.:      ||...:|:|.|
Human   690 RSGSSLVSPF-----------SSATAALPPSLNLTTPASTSQDASQCQPSPDFSHDRQLRLLLSQ 743

  Fly   688 QNELRIVSEQLLLSRYTYLQPMMSMGFAPGNMTAAAVGNLGASGQRGLNFTGSNAVQPQFNQYGF 752
            .                 :||||     ||:..|.....:..:| |.:.:..|..|..  |....
Human   744 P-----------------IQPMM-----PGSCDARQPSEVSRTG-RQVKYAQSQTVFQ--NPDAH 783

  Fly   753 ALNSEQMLNQQDQQMMMQQQQNLHTQHQHNLQQQHQSHSQLQQHTQQQHQQQQQQQQQQQQQQQQ 817
            ..||    :.....:::..|..||...                          ...|....|..|
Human   784 PANS----SSAPMPVLLMGQAVLHPSF--------------------------PASQPSPLQPAQ 818

  Fly   818 QQQQQQQQQQQQQQQQQLQLQQQNDILL 845
            .:||..|...|.|....|..:||:.:||
Human   819 ARQQPPQHYLQVQAPTSLHSEQQDSLLL 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	30/51 (59%)
		PAS	93..153	CDD:214512	24/59 (41%)
		PAS	264..366	CDD:238075	77/101 (76%)
		PAS_11	265..368	CDD:291273	78/102 (76%)
NPAS2	XP_005264010.1	HLH	72..126	CDD:238036	31/57 (54%)
		PAS	149..214	CDD:214512	26/64 (41%)
		PAS_9	159..260	CDD:290162	34/100 (34%)
		PAS_11	314..417	CDD:291273	78/102 (76%)
		PAS	315..415	CDD:238075	77/99 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144522
Domainoid	1	1.000	198	1.000	Domainoid score	I3074
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1839
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002532
OrthoInspector	1	1.000	-	-		otm41707
orthoMCL	1	0.900	-	-		OOG6_105251
Panther	1	1.100	-	-	O	PTHR46055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4514
SonicParanoid	1	1.000	-	-		X1900
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.780