DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clk and sima

DIOPT Version :9

Sequence 1:	NP_001014576.1	Gene:	Clk / 38872	FlyBaseID:	FBgn0023076	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001287599.1	Gene:	sima / 43580	FlyBaseID:	FBgn0266411	Length:	1593	Species:	Drosophila melanogaster

Alignment Length:	1320	Identity:	288/1320 - (21%)
Similarity:	463/1320 - (35%)	Gaps:	467/1320 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KSRNLSEKKRRDQFNSLVNDLSALISTSS---RKMDKSTVLKSTIAFLK---------NHNEATD 70
            |||: :.:.||.:...:..:|||.:...:   .::||::|::.||||||         :..:..|
  Fly   162 KSRD-AARCRRSKETEIFMELSAALPLKTDDVNQLDKASVMRITIAFLKIREMLQFVPSLRDCND 225

  Fly    71 RSK----VFEIQQDWKPA-------FLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLG 124
            ..|    ..|.||:.||.       :|:..|...|:.:::|||::|.|..|.|.|.||::...||
  Fly   226 DIKQDIETAEDQQEVKPKLEVGTEDWLNGAEARELLKQTMDGFLLVLSHEGDITYVSENVVEYLG 290

  Fly   125 YLPQDLYNMTIYDLAYEMDH----EAL-LNIFMNPTPVIEPRQTDISSSNQITFYTHLR-----R 179
            ....|.....|::.:::.||    ||| |...:......||:|....|::....:..|:     |
  Fly   291 ITKIDTLGQQIWEYSHQCDHAEIKEALSLKRELAQKVKDEPQQNSGVSTHHRDLFVRLKCTLTSR 355

  Fly   180 GGMEKVDANAYELVKFVGYFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVG 244
            |....:.:.:|:::...|:.                       |:        ||:.::.|:.:|
  Fly   356 GRSINIKSASYKVIHITGHL-----------------------VV--------NAKGERLLMAIG 389

  Fly   245 TGRVQNPQLIREMSIIDPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDL 309
            . .:.:|..|.    |...::.|.:|||::.:|.::|.:...::||.|.::|.||.:...|..|.
  Fly   390 R-PIPHPSNIE----IPLGTSTFLTKHSLDMRFTYVDDKMHDLLGYSPKDLLDTSLFSCQHGADS 449

  Fly   310 DSIVACHEELRQTGEGKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAE--- 371
            :.::|..:.:...|:|::..||||.|...:.|:.:...:.|.:.  ||..|||.:.|:|..|
  Fly   450 ERLMATFKSVLSKGQGETSRYRFLGKYGGYCWILSQATIVYDKL--KPQSVVCVNYVISNLENKH 512

  Fly   372 -------------------VLKDSRKEGQKSGNSNSITNNGSSKVIASTGTSSKSASATTTLRDF 417
                               ...::.||.:|:.:...|.......|.....||...|      :..
  Fly   513 EIYSLAQQTAASEQKEQHHQAAETEKEPEKAADPEIIAQETKETVNTPIHTSELQA------KPL 571

  Fly   418 ELSSQNLDSTLLGNSLASLGTETAATSPAVDSSPMWSASAVQPSGSCQINPLKTSRPASSYGNI- 481
            :|.|:..:.|:       ..|:|.||.|.|.::          |.:.||..|..|.|   |..|
  Fly   572 QLESEKAEKTI-------EETKTIATIPPVTAT----------STADQIKQLPESNP---YKQIL 616

  Fly   482 -------------------------SSTGISPKAKRKCYFYNNRGNDSDS--------------- 506
                                     ||:|:.|:.||......:....|.:
  Fly   617 QAELLIKRENHSPGPRTITAQLLSGSSSGLRPEEKRPKSVTASVLRPSPAPPLTPPPTAVLCKKT 681

  Fly   507 ----------TSMSTDSVTSRQSMMTHVSSQSQRQR----------------------------- 532
                      |:.:|.::.|..:....::.|:|.|.
  Fly   682 PLGVEPNLPPTTTATAAIISSSNQQLQIAQQTQLQNPQQPAQDMSKGFCSLFADDGRGLTMLKEE 746

  Fly   533 ----SHH---------------------------------------------REHHR-------- 540
                |||                                             .:|::
  Fly   747 PDDLSHHLASTNCIQLDEMTPFSDMLVGLMGTCLLPEDINSLDSTTCSTTASGQHYQSPSSSSTS 811

  Fly   541 --------ENHH-----------------NQSHHHMQQQQQHQNQQQQHQQHQQLQ-QQLQHTVG 579
                    .|.:                 |.||   ||||||.|||||.||.||.. |...::..
  Fly   812 APSNTSSSNNSYANSPLSPLTPNSTATASNPSH---QQQQQHHNQQQQQQQQQQHHPQHHDNSNS 873

  Fly   580 TPKMVPLLPIASTQIMAGNACQFPQPAYPLASPQLVAPTFLEPPQYLT--------AIPMQPVIA 636
            :..:.||............:.....|:....||:..:...|..|..||        |..|:.
  Fly   874 SSNIDPLFNYREESNDTSCSQHLHSPSITSKSPEDSSLPSLCSPNSLTQEDDFSFEAFAMRA--- 935

  Fly   637 PFPVAPVLSPLPVQSQTDML----PDTVVMTP-----TQSQLQDQLQRKH-----------DELQ 681
              |..|:...:|:.::||::    .|...|.|     .|.||| |||::|           .:.|
  Fly   936 --PYIPIDDDMPLLTETDLMWCPPEDLQTMVPKEIDAIQQQLQ-QLQQQHHQQYAGNTGYQQQQQ 997

  Fly   682 KLILQQQNELRIVSEQLLLSRYT------------YLQPMMSMGFAPGNMTAAAVGNLGASGQRG 734
            :..||||:    .|..|..|..:            :.|...:..|...:...||:  |..||...
  Fly   998 QPQLQQQH----FSNSLCSSPASTVSSLSPSPVQQHHQQQQAAVFTSDSSELAAL--LCGSGNGT 1056

  Fly   735 LNFTGSNAVQPQFNQYGFALNSEQMLNQQDQQMMMQQQQNLHTQHQHNLQQQHQSHSQLQQHTQQ 799
            |:...           |..:...:..|::.||...||||.  :.::....||.|...|||:..||
  Fly  1057 LSILA-----------GSGVTVAEECNERLQQHQQQQQQT--SGNEFRTFQQLQQELQLQEEQQQ 1108

  Fly   800 QHQQQQQQQQQQQQQQ------------------------------------------------- 815
            :.||||||||||||||
  Fly  1109 RQQQQQQQQQQQQQQQLLSLNIECKKEKYDVQMGGSLCHPMEDAFENDYSKDSANLDCWDLIQMQ 1173

  Fly   816 -------------------------QQQQQQQQQQQQQQ-------------------QQQQQLQ 836
                                     |||||.||||||||                   |||||.|
  Fly  1174 VVDTEPVSPNAASPTPCKVSAIQLLQQQQQLQQQQQQQQNIILNAVPLITIQNNKELMQQQQQQQ 1238

  Fly   837 LQQQNDILLREDIDDIDAFLNLSPLHSLGSQSTINPFNSSSNNNNQSYNGGSNL-----NNGNQN 896
            .|||.:.|.:..|    ..||.:.:..:.:::||....|......||.....||     .:||:.
  Fly  1239 QQQQQEQLQQPAI----KLLNGASIAPVNTKATIRLVESKPPTTTQSRMAKVNLVPQQQQHGNKR 1299

  Fly   897 NNNRSS---NPPQNNNEDSLLSCMQMATESSPSINFHMGISDDGSETQSEDNKMMHTSGSNLVQQ 958
            :.|.::   ||.::....|...|:.:   .||.: ....|..|.::.|::..|...:....|..:
  Fly  1300 HLNSATGAGNPVESKRLKSGTLCLDV---QSPQL-LQQLIGKDPAQQQTQAAKRAGSERWQLSAE 1360

  Fly   959 QQQQQQQQQILQQHQQQSNS 978
            .:||:||       ||||||
  Fly  1361 SKQQKQQ-------QQQSNS 1373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	17/61 (28%)
		PAS	93..153	CDD:214512	21/64 (33%)
		PAS	264..366	CDD:238075	29/101 (29%)
		PAS_11	265..368	CDD:291273	30/102 (29%)
sima	NP_001287599.1	HLH	156..209	CDD:238036	15/47 (32%)
		PAS	256..392	CDD:279347	36/167 (22%)
		PAS	265..>317	CDD:238075	17/51 (33%)
		PAS	404..505	CDD:238075	29/102 (28%)
		PAS_3	417..502	CDD:285623	25/86 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910