Protein Alignment Clk and sim

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_524340.2
• Gene: sim / 41612
• FlyBaseID: FBgn0004666
• Length: 688
• Species: Drosophila melanogaster
• Alignment Length: 855
• Identity: 174/855 - (20%)
• Similarity: 303/855 - (35%)
• Gaps: 253/855 - (29%)

  Fly    18 KSRNLSEKKRRDQFNSLVNDLSALI---STSSRKMDKSTVLKSTIAFLKNHNEATDRSKVFEIQQ 79
            ||:| :.:.||::.|:...:|:.|:   :..:.::||::|::.|.::||......|     .:.:
  Fly    28 KSKN-AARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPD-----GLGE 86

  Fly    80 DW--KPAFLSNDEYTHL---MLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTIYDLA 139
            .|  .||.........|   :|::||||:.|.:..|.|.|.||:.:..||....:|...:|::..
  Fly    87 AWGSSPAMQRGATIKELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFEYI 151

  Fly   140 YEMDHE---ALLNI--FMNPTPVIEPRQTDISSSNQI---TFYTHLRRGGMEKVDANAYELVKFV 196
            :..|.:   |:|::  .:|..|:.: ..|.|.|.|.:   :.|.|.|.....:::...:..:|.|
  Fly   152 HNYDQDEMNAILSLHPHINQHPLAQ-THTPIGSPNGVQHPSAYDHDRGSHTIEIEKTFFLRMKCV 215

  Fly   197 GYFRNDTNTSTGSSSEVSNG----------SNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNP 251
            ...||...|::|......:|          .:||.:::     ||        |..|..|.....
  Fly   216 LAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLI-----QN--------LGLVAVGHSLPS 267

  Fly   252 QLIREMSIIDPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACH 316
            ..|.|:.:   ..|.|..:..::.|.:|.|.|...:.||.|.:::..:.|.|.|..|:.::...|
  Fly   268 SAITEIKL---HQNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEKTLYQYIHAADIMAMRCSH 329

  Fly   317 EELRQTGEGKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKEGQ 381
            :.|...|:..:.||||||||..|:|:|:...:.::..:|:..::|..:.|:|..|| ||
  Fly   330 QILLYKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREV-KD------ 387

  Fly   382 KSGNSNSITNNGSSKVIASTGTSSKSASATTTLRDFELSSQNLDSTLLGNSLASLGTETAATSPA 446
                  .:.|...:.|:.....|..:.:|.                      |:...:.|..:.|
  Fly   388 ------LVLNEIQTGVVKREPISPAAQAAQ----------------------AAQAAQAAQAAQA 424

  Fly   447 VDSSPMWSASAVQ------PSGSCQINPL---KTSRPASSYGNISSTGISPKAKRKCYFYNNRGN 502
            ..::.:  |.|||      |..|..:.|.   .|.:|... |...|..:|...|...||
  Fly   425 AQAAHV--AQAVQAQVVVVPQQSVVVQPQCAGATGQPVGP-GTPVSLALSASPKLDPYF------ 480

  Fly   503 DSDSTSMSTDSVTSRQSMMTHVSSQSQRQRSHHREHHRENHHN--QSHHHMQQQQQHQNQQQQHQ 565
                     :.....|..:|.|...:....|       .|::|  ..|||:|||||..:......
  Fly   481 ---------EPELPLQPAVTPVPPTNNSSSS-------SNNNNGVWHHHHVQQQQQSGSMDHDSL 529

  Fly   566 QHQQLQQQLQHTVGTPKMVPLLPIASTQIMAGNACQFPQPAYPLASPQLVAPTFLEPPQYLTAIP 630
            .:.||.         |.:..|:..:|:.:..|.|......:...||...|..|.:   ||
  Fly   530 SYTQLY---------PPLNDLVVSSSSSVGGGTASSAGGGSSASASSSGVYSTEM---QY----- 577

  Fly   631 MQPVIAPFPVAPVLSPLPVQSQTDMLPDTVVMTPTQSQLQDQLQRKHDELQKLILQQQNELRIVS 695
                                      |||
  Fly   578 --------------------------PDT------------------------------------ 580

  Fly   696 EQLLLSRYTYLQPMMSMGFAPGNMTAAAVGNLGASGQRGLNF-------TGSNAVQPQFNQYGFA 753
                                       ..|||..:......:       ..::.::|      |:
  Fly   581 ---------------------------TTGNLYYNNNNHYYYDYDATVDVATSMIRP------FS 612

  Fly   754 LNSEQMLNQQDQQMMM-----------QQQQNLHTQHQHNLQQQHQSHSQLQQHTQQQHQQQQQQ 807
            .||....:..:.:..:           ...|..::...||.:..:.|.:..|||   |||||||.
  Fly   613 ANSNSCSSSSESERQLSTGNASIVNETSPSQTTYSDLSHNFELSYFSDNSSQQH---QHQQQQQH 674

  Fly   808 QQQQQQQQQQ 817
            ..:||..|.|
  Fly   675 LMEQQHLQYQ 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	18/72 (25%)
		PAS	93..153	CDD:214512	19/67 (28%)
		PAS_11	265..368	CDD:464214	30/102 (29%)
sim	NP_524340.2	bHLH-PAS_dSIM_like	25..86	CDD:381583	15/63 (24%)
		PAS	102..215	CDD:395786	29/113 (26%)
		PAS_3	291..377	CDD:430001	26/85 (31%)