DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clk and tgo

DIOPT Version :9

Sequence 1:	NP_001014576.1	Gene:	Clk / 38872	FlyBaseID:	FBgn0023076	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster

Alignment Length:	750	Identity:	174/750 - (23%)
Similarity:	284/750 - (37%)	Gaps:	211/750 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DESDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSS---RKMDKSTVLKSTIAFLK- 63
            ||::.:|..: |..|::....|::||::..:.:.:||.::.|.|   ||.||.|:|:..:|.:|
  Fly     2 DEANIQDKER-FASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKA 65

  Fly    64 ---NHNEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFS-SMGSIFYASESITSQLG 124
               ..|.::|.:        :||:||::.|..||:||:.|||:.|.| ..|.:.|.|:|:|..|.
  Fly    66 LRGTGNTSSDGT--------YKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLN 122

  Fly   125 YLPQDLYNMTIYDLAYEMDHEALLNIF-----MNPTPVIEPRQTDI-----SSSNQIT------F 173
            |...|.|..::|:..:..|.|.:....     .|...:::.:...:     .||.:::      |
  Fly   123 YTQSDWYGTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGF 187

  Fly   174 YTHLRRGGME--------------------KVDANAYELVKFVGYFRNDTNTSTGSSSEVSNGSN 218
            ...:|.|.:.                    ..|...|.:|...||.:|...|.
  Fly   188 ICRMRVGNVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTGYIKNWPPTD------------ 240

  Fly   219 GQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQ-NPQLIREMSIIDPTSNEFTSKHSMEWKFLFLDH 282
                :.|.:..:....::......|..||:| ......:||..: ..:||.::|:|:.||.|:|.
  Fly   241 ----MFPNMHMERDVDDMSSHCCLVAIGRLQVTSTAANDMSGSN-NQSEFITRHAMDGKFTFVDQ 300

  Fly   283 RAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEE-LRQTGEGKSCYYRFLTKGQQWIWLQTDY 346
            |...|:||.|.|:||...||::|.:|...:....:: |:|.|:..|..||...|..:::||:|..
  Fly   301 RVLNILGYTPTELLGKICYDFFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQA 365

  Fly   347 YVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKEGQKSGNSNSITNNGSSKVIASTGTSSKSASAT 411
            |...:.:..:.:|:|||                     ||:..|.:|          :...|:|.
  Fly   366 YAFLNPYTDEVEYIVCT---------------------NSSGKTMHG----------APLDAAAA 399

  Fly   412 TTLRDFELSSQNLDSTLLGNSLASLGTETA---------ATSPAVDSSPMWSASAVQPS------ 461
            .|....:...|......:   .|:.|.:.|         ||:..:..:.|.:..|..|.
  Fly   400 HTPEQVQQQQQQEQHVYV---QAAPGVDYARRELTPVGSATNDGMYQTHMLAMQAPTPQQQQQQQ 461

  Fly   462 ---GSCQINPL-----KTSRPASSYG-----NISSTGISPKAKRKCYFYNNRGNDSDSTSMSTDS 513
               ||.|..|:     .|..|.|:.|     .|..:|.||                  |.::.:|
  Fly   462 QRPGSAQTTPVGYTYDTTHSPYSAGGPSPLAKIPKSGTSP------------------TPVAPNS 508

  Fly   514 VTSRQSMMTHVSSQSQRQRSHHREHHRENHHNQSHHHMQQQQQHQNQQQQHQQHQQLQQQLQHTV 578
            ..:.:.                                |||||.|....:..|:||.
  Fly   509 WAALRP--------------------------------QQQQQQQQPVTEGYQYQQT-------- 533

  Fly   579 GTPKMVPLLPIASTQIMAGNA-CQFPQP-AYPLASPQLV-APTFLE--------PPQYLTAIPMQ 632
             :|...|..| ..||:.|||. .|..|| ||....|... ||...:        .|.:.||.|..
  Fly   534 -SPARSPSGP-TYTQLSAGNGNRQQAQPGAYQAGPPPPPNAPGMWDWQQAGGHPHPPHPTAHPHH 596

  Fly   633 PVIAPFPVAPVLSPLPVQSQ--TDMLPDTVVMTPT 665
            |...|...|....|   |.|  :||| ..:..|||
  Fly   597 PHAHPGGPAGAGQP---QGQEFSDML-QMLDHTPT 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	17/58 (29%)
		PAS	93..153	CDD:214512	21/65 (32%)
		PAS	264..366	CDD:238075	35/102 (34%)
		PAS_11	265..368	CDD:291273	35/103 (34%)
tgo	NP_001262397.1	HLH	15..67	CDD:278439	16/51 (31%)
		PAS	87..192	CDD:279347	26/104 (25%)
		PAS	90..154	CDD:214512	21/63 (33%)
		PAS_11	283..384	CDD:291273	35/121 (29%)
		PAS	283..380	CDD:238075	32/96 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444967
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740