Protein Alignment Clk and ARNTL

DIOPT Version :9

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_016873227.1
• Gene: ARNTL / 406
• HGNCID: 701
• Length: 674
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 155/611 - (25%)
• Similarity: 249/611 - (40%)
• Gaps: 167/611 - (27%)

  Fly     7 DKDDTKSFL-----------CRKSRNLSEKKRRDQFNSLVNDLSALIST---SSRKMDKSTVLKS 57
            ||||....|           .|::.:..||:|||:.||.:::|::|:.|   .|||:||.|||:.
Human    96 DKDDPHGRLEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRM 160

  Fly    58 TIAFLKNHNEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFS-SMGSIFYASESITS 121
            .:..:|....||:.    ..:.::||.|||:||..||:|.:.|||:.|.. ..|.|.:.|||:..
Human   161 AVQHMKTLRGATNP----YTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFK 221

  Fly   122 QLGYLPQDLYNMTIYDLAYEMD---------------HEALLNIFMNPTPV---IEPRQTDISSS 168
            .|.|...||...:::|..:..|               .|.|::. ....||   |.|..:.:.|.
Human   222 ILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDA-KTGLPVKTDITPGPSRLCSG 285

  Fly   169 NQITFYTHLRRG---------------GMEKVDANAYELVKFVGYFRNDTNTSTGSSSEVSNGSN 218
            .:.:|:..::..               ..:|.|..::..:...||.::...|..|...:
Human   286 ARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKADRKSFCTIHSTGYLKSWPPTKMGLDED------ 344

  Fly   219 GQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQN---PQLIR-EMSIIDPTSNEFTSKHSMEWKFLF 279
                       ..|:.|.......|..||:.:   ||.:. |:.:   .|.|:.|:|:::.||:|
Human   345 -----------NEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRV---KSMEYVSRHAIDGKFVF 395

  Fly   280 LDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGE--GKSCYYRFLTKGQQWIWL 342
            :|.||..|:.|:|.|:||||.|:|:|.||:..:..||.::.||.|  ..:| |:|..|...:|.|
Human   396 VDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNC-YKFKIKDGSFITL 459

  Fly   343 QTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKEGQKSGNSNSITNNGSSKVIASTGTSSKS 407
            ::.::...:.:..:.:|:|.|:.|| .|.||     ||
Human   460 RSRWFSFMNPWTKEVEYIVSTNTVV-LANVL-----EG--------------------------- 491

  Fly   408 ASATTTLRDFELSSQNLDSTL-LGNSLASLG--TETAATSPAVDSSPMWSASAV----------- 458
              ...|......|..::||.| .|.....:|  ..|..|.|.:.......|..:
Human   492 --GDPTFPQLTASPHSMDSMLPSGEDSFVVGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEI 554

  Fly   459 ------QPSGSCQINPLK-TSRP---ASSYG----------NISSTG-ISPKAKRK-CYFYNNRG 501
                  .|| ||..:||. ||.|   |||.|          :|.|:| :|.:|:.. .|.|::..
Human   555 HRIRGSSPS-SCGSSPLNITSTPPPDASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSS 618

  Fly   502 ---------------NDSDSTSMSTD 512
                           ||..|:|.|.|
Human   619 SILGENPHIGIDMIDNDQGSSSPSND 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	20/54 (37%)
		PAS	93..153	CDD:214512	20/75 (27%)
		PAS	264..366	CDD:238075	37/103 (36%)
		PAS_11	265..368	CDD:291273	37/104 (36%)
ARNTL	XP_016873227.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810