DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clk and ARNT

DIOPT Version :9

Sequence 1:	NP_001014576.1	Gene:	Clk / 38872	FlyBaseID:	FBgn0023076	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001659.1	Gene:	ARNT / 405	HGNCID:	700	Length:	789	Species:	Homo sapiens

Alignment Length:	734	Identity:	164/734 - (22%)
Similarity:	278/734 - (37%)	Gaps:	209/734 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DDESDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSS---RKMDKSTVLKSTIAFLK 63
            |||....|  |..|.|::.:..|::||::..:.:.:||.::.|.|   ||.||.|:|:..::.:|
Human    78 DDEQSSAD--KERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK 140

  Fly    64 N----HNEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFS-SMGSIFYASESITSQL 123
            :    .|.:||.|        :||:||::.|..||:||:.|||:.:.| ..|.:.|.|:|:|..|
Human   141 SLRGTGNTSTDGS--------YKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVL 197

  Fly   124 GYLPQDLYNMTIYDLAYEMDHEALLNIFMNPTPVIEPRQTDISS----------------SNQIT 172
            .....:.:..|:||..:..|.:.|..........:..|..|:.:                .::.:
Human   198 NQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRS 262

  Fly   173 FYTHLRRGGMEKVDANAYELVKFVGYFRNDTNTSTGSSSEVSNGSNGQP---------------- 221
            |...:|.|. ..||..:...:.||   ||......||..:      |:|
Human   263 FICRMRCGS-SSVDPVSVNRLSFV---RNRCRNGLGSVKD------GEPHFVVVHCTGYIKAWPP 317

  Fly   222 --AVLPRIFQQNPNAEVDKKLVFVGTGRVQ---NPQLIREMSIIDPTSNEFTSKHSMEWKFLFLD 281
              ..||   ..:|.|....|...|..||:|   :|......::..||  ||.|:|::|..|.|:|
Human   318 AGVSLP---DDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPT--EFISRHNIEGIFTFVD 377

  Fly   282 HRAPPIIGYMPFEVLGTSGYDYYHFDD----LDSIVACHEELRQTGEGKSCYYRFLTKGQQWIWL 342
            ||....:||.|.|:||.:..::.|.:|    .||.   .:.::..|:..|..:||.:|.|:|:|:
Human   378 HRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSF---QQVVKLKGQVLSVMFRFRSKNQEWLWM 439

  Fly   343 QTDYYVSYHQFNSKPDYVVCTHKVVSYAE-----VLKDSRKEGQKSGNSNSITNNGSSKV----- 397
            :|..:...:.::.:.:|::||:..|..:.     .|.::.:..|....:|.....||.::
Human   440 RTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGSGQLAPRQQ 504

  Fly   398 --------------------------IASTG-------------------------------TSS 405
                                      :.:||                               ..|
Human   505 QQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQDRDPRFSEIYHNINADQS 569

  Fly   406 KSASATTTLRDFELSSQNLDSTLLGNSL-------------------------ASLGTETAATS- 444
            |..|::|.....:|.||       ||:.                         ||.|...|..|
Human   570 KGISSSTVPATQQLFSQ-------GNTFPPTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISR 627

  Fly   445 ---PAVDSSPMWSASAVQPSGSCQINPLKTSR------------PASSYGNISSTGISPKAKRKC 494
               |...::|.|:.:......:.|:....|::            ..||:.::|..| :|.|....
Human   628 HSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTSQFGVGSFQTPSSFSSMSLPG-APTASPGA 691

  Fly   495 YFY---NNRG-NDSDSTSMSTDSVTSRQSMMTHVSSQSQRQRSHHREHHRENHHNQSHHHMQQQQ 555
            ..|   .||| |.:..|..:.....:|.:....|..|.|.|:.|||.       :.|..|:||.
Human   692 AAYPSLTNRGSNFAPETGQTAGQFQTRTAEGVGVWPQWQGQQPHHRS-------SSSEQHVQQP- 748

  Fly   556 QHQNQQQQHQQHQQLQQQL 574
                ..||..|.:..|:.|
Human   749 ----PAQQPGQPEVFQEML 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	16/58 (28%)
		PAS	93..153	CDD:214512	19/60 (32%)
		PAS	264..366	CDD:238075	32/105 (30%)
		PAS_11	265..368	CDD:291273	32/106 (30%)
ARNT	NP_001659.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..97		7/20 (35%)
		DNA-binding. /evidence=ECO:0000269\|PubMed:28396409	88..128		11/39 (28%)
		HLH	91..143	CDD:278439	15/51 (29%)
		Required for heterodimer formation with EPAS1. /evidence=ECO:0000250\|UniProtKB:P53762	112..264		41/159 (26%)
		Required for heterodimer formation with HIF1A. /evidence=ECO:0000250\|UniProtKB:P53762	112..168		21/63 (33%)
		PAS	163..269	CDD:279347	23/105 (22%)
		PAS	166..230	CDD:214512	19/63 (30%)
		Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000250\|UniProtKB:P53762	167..171		2/3 (67%)
		PAS_11	362..462	CDD:291273	32/102 (31%)
		PAS	362..458	CDD:238075	30/98 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..492		3/26 (12%)
		Med3	<523..>734	CDD:288447	38/218 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	672..789		29/105 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810