DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clk and cyc

DIOPT Version :9

Sequence 1:	NP_001014576.1	Gene:	Clk / 38872	FlyBaseID:	FBgn0023076	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster

Alignment Length:	413	Identity:	106/413 - (25%)
Similarity:	196/413 - (47%)	Gaps:	64/413 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DDESDDKDDTKSFLCRKSRNLS--EKKRRDQFNSLVNDLSALIS---TSSRKMDKSTVLKSTIAF 61
            |:..|::...::....:.:|.|  ||:|||:.|:.:|:||::|.   ...||:||.|||:..:..
  Fly    15 DENYDEEKSARTSDENRKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRMAVQH 79

  Fly    62 LKNHNEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFS-SMGSIFYASESITSQLGY 125
            |:. ...:.....|. ..|::|:|||:.|...::|::.:||:.|.. ..|.|.|.|:|::|.|..
  Fly    80 LRG-IRGSGSLHPFN-GSDYRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVSDSVSSVLNS 142

  Fly   126 LPQDLYNMTIYDLAYEMD----HEALLNIFMNP------TPVIEPRQTDISSS-------NQITF 173
            ...||...:.:|:.:..|    .|.|.::...|      ...:.|.:||:..|       .:.:|
  Fly   143 TQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCRLCPGARRSF 207

  Fly   174 YTHLRRGGMEKVDANAYELVKFVGYFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQ--------- 229
            :..::.    :..:|        ...:.:::||:.|.|.....|........|:.|
  Fly   208 FCRMKL----RTASN--------NQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWT 260

  Fly   230 ----QNPNAEVDKKLV----FVGTGRVQNPQLIREMSIIDPTSNE-------FTSKHSMEWKFLF 279
                ::.:|:.|::..    .|..||:  |..:|..::.....|.       |.|:||.|.||||
  Fly   261 PIKDEDQDADSDEQTTNLSCLVAIGRI--PPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLF 323

  Fly   280 LDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGEGKSC-YYRFLTKGQQWIWLQ 343
            :|.||..:||::|.|:||||.|:|:|.:|:.:::..|:.:.|..|..:. .|||..|...:|.||
  Fly   324 IDQRATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQ 388

  Fly   344 TDYYVSYHQFNSKPDYVVCTHKV 366
            :::....:.:.|:.||::..:.|
  Fly   389 SEWRAFKNPWTSEIDYIIAKNSV 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	20/56 (36%)
		PAS	93..153	CDD:214512	17/64 (27%)
		PAS	264..366	CDD:238075	38/109 (35%)
		PAS_11	265..368	CDD:291273	39/110 (35%)
cyc	NP_524168.2	HLH	31..84	CDD:278439	20/53 (38%)
		PAS	111..212	CDD:279347	23/100 (23%)
		PAS	111..173	CDD:214512	17/61 (28%)
		PAS_11	311..411	CDD:291273	37/99 (37%)
		PAS	311..406	CDD:238075	37/94 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810