Protein Alignment Clk and hif1ab

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_001296971.1
• Gene: hif1ab / 393202
• ZFINID: ZDB-GENE-040426-706
• Length: 777
• Species: Danio rerio
• Alignment Length: 867
• Identity: 181/867 - (20%)
• Similarity: 330/867 - (38%)
• Gaps: 211/867 - (24%)

  Fly    18 KSRNLSEKKR---RDQFNSLVNDLSALISTSSRKMDKSTVLKSTIAFLK-----NHNEATDRSKV 74
            |||:.:..:|   .:.|..|.:.|....:.:|. :||:::::.||::|:     |.:|..::.:
Zfish    20 KSRDAARSRRGKESEVFYELAHQLPLPHNVTSH-LDKASIMRLTISYLRMRKLLNSDEKEEKEE- 82

  Fly    75 FEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTIYDLA 139
            .|::          .:.....|::|:||:||.|..|.:.|.||:::..:|....||...:|::.:
Zfish    83 NELE----------SQLNGFYLKALEGFLMVLSEDGDMVYLSENVSKSMGLTQFDLTGHSIFEFS 137

  Fly   140 YEMDHEALLNIFMNPTPVIEPRQTDISSSNQITFYTHLR-----RGGMEKVDANAYELVKFVGYF 199
            :..|||.|..:.::.|...:.::.:...|    |:..::     ||....:.:..::::...|:.
Zfish   138 HPCDHEELREMLVHRTGSKKTKEQNTERS----FFLRMKCTLTSRGRTVNIKSATWKVLHCAGHV 198

  Fly   200 RNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSIIDPTS 264
            |    ...||.:...:|.. :|.|...:....|               :.:|..|.    :...|
Zfish   199 R----VHEGSEASEDSGFK-EPPVTYLVLICEP---------------IPHPSNIE----VPLDS 239

  Fly   265 NEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGEGKSCY 329
            ..|.|:|:::.||.:.|.|...::||.|.::|..|.|:|||..|.|.:...|..|...|:..:..
Zfish   240 KTFLSRHTLDMKFSYCDERITELMGYEPDDLLNRSVYEYYHALDSDHLTKTHHNLFAKGQATTGQ 304

  Fly   330 YRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVS-----------------YAEVLKDSR 377
            ||.|.|...::|::|...|.|:..||:|..:||.:.|:|                 ...|.|:|.
Zfish   305 YRMLAKKGGFVWVETQATVIYNPKNSQPQCIVCVNYVLSGIVEGDVVLSLQQTVTEPKAVEKESE 369

  Fly   378 KEGQKSG-----------------NSNSITNNGSSKVIASTGTSSKSASATTTLRDFELSSQNL- 424
            :..:|:.                 .|:::.|....:..|.|..:..:..|..:| ||..|..::
Zfish   370 ETEEKTSELDILKLFKPESLNCSLESSTLYNKLKEEPEALTVLAPAAGDAIISL-DFNNSDSDIQ 433

  Fly   425 --------DSTLLGNSLASLGTETAATSPAVDS-------------SPMWSAS--AVQPSGSCQI 466
                    :..:|.:|...|....:..:|: ||             .|..|||  ...|:.:...
Zfish   434 LLKEVPLYNDVMLPSSSEKLPLSLSPLTPS-DSIPALTKLETGGEDFPFSSASDRVPDPTNTPST 497

  Fly   467 NPLKTSRPAS--SYGNISSTGISPKAK----RKCYFYNNRGNDSDSTSMSTDSVTSRQSMMTHVS 525
            :.|.:|.|.|  .||......||.:.|    .|.:..:.......||....|  ...:.:..::.
Zfish   498 SGLGSSGPNSPMDYGFPVEPDISSEFKLDLVEKLFAIDTEAKTPFSTQPMED--LDLEMLAPYIP 560

  Fly   526 SQSQRQRSHHREHHRENHHNQSHHHMQQQQQHQNQQQQHQQHQQLQQQLQHTVGTPKMVPLLPIA 590
            .....|                                              :..|..:..||.|
Zfish   561 MDDDFQ----------------------------------------------LRIPSPLDPLPSA 579

  Fly   591 STQIMAGNACQFPQPAYPLASP------------QLVAPTFLEPPQYLTAIPMQPVIAPFPVAPV 643
            :..:.|.::...|.|:.| |||            ...||:.|...|.:.:.|:.|.......:||
Zfish   580 THSVSAMSSLFQPLPSSP-ASPASSTSSTVKQEASSRAPSPLHLLQEVCSAPVSPFSGSRDASPV 643

  Fly   644 LSPLPVQSQTDMLPDTVVMTPTQSQLQDQLQRKHDELQKLILQQQNELRIVSE-----QLLLSRY 703
            .|..| ||.:.:  :...|:|.....|: :|||    :||     ||:..:||     .||.|..
Zfish   644 RSSTP-QSSSQL--NNREMSPKMLAFQN-IQRK----RKL-----NEVTSLSEAVGLGALLHSVD 695

  Fly   704 TYLQP--------MMSMGFAPGNMTAAAVGNLGASGQRGLNFTGSNAVQPQFNQYGFALNSEQML 760
            :.:.|        :.......||.|...:.:..||.....:..||..: ||..:|...:|:.
Zfish   696 SAIDPGKRAKVLEVKGSSVLGGNKTILILPSDVASRLLSSSLEGSGGL-PQLTRYDCEVNAP--- 756

  Fly   761 NQQDQQMMMQQQQNLHTQHQHN 782
             .||:..::|.::.|....|.|
Zfish   757 -VQDRHHLLQGEELLRALDQVN 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	16/75 (21%)
		PAS	93..153	CDD:214512	19/59 (32%)
		PAS_11	265..368	CDD:464214	35/102 (34%)
hif1ab	NP_001296971.1	bHLH_SF	12..75	CDD:469605	14/55 (25%)
		PAS	94..149	CDD:214512	19/54 (35%)
		PAS_3	254..339	CDD:430001	29/84 (35%)
		HIF-1	543..574	CDD:463274	5/78 (6%)
		HIF-1a_CTAD	740..776	CDD:430212	9/40 (23%)