Protein Alignment Clk and npas2

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_840084.1
• Gene: npas2 / 352934
• ZFINID: ZDB-GENE-030408-3
• Length: 845
• Species: Danio rerio
• Alignment Length: 1045
• Identity: 314/1045 - (30%)
• Similarity: 462/1045 - (44%)
• Gaps: 278/1045 - (26%)

  Fly     1 MDD--ESDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSS--RKMDKSTVLKSTIAF 61
            :||  :.|:||..|    |.|||.||||||||||.|:.:|..::....  |||||||:|:.||.|
Zfish    30 VDDLMDEDEKDRAK----RASRNKSEKKRRDQFNVLIKELCTMLQGQGHPRKMDKSTILQRTIDF 90

  Fly    62 LKNHNEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYL 126
            |:...|.|.:::..|::|||||:||||:|:|.||||:||||::..::.|:|.|.|:|::|.:|:|
Zfish    91 LQKQKEITAQTESCEVRQDWKPSFLSNEEFTQLMLEALDGFLIALTTDGNIIYVSDSVSSLIGHL 155

  Fly   127 PQDLYNMTIYDLAYEMDHEALLNIFMNPTPVIEPRQTDISSSNQ--ITFYTHLRRGGMEKVDANA 189
            |.|:.:..|.:...|.:|..:..:..:...:.|....|:.:||:  :.|..|:.||.::..:...
Zfish   156 PSDMVDQNILNFLPEREHADVYKLLSSHMLLTESSTVDLLNSNETHVEFCCHIARGNIDPKEPPT 220

  Fly   190 YELVKFVGYFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLI 254
            ||.|||||.|:...|....|       .||.....||..|    :.:::::..|.|.|:..||.:
Zfish   221 YEYVKFVGDFKFHNNVPLSS-------CNGYDLAFPRTLQ----SSIEEQVCLVATVRLATPQFL 274

  Fly   255 REMSIIDPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEEL 319
            :::..::...:||||:||:|||||||||||.|||||:||||||||||||||.|||:.|..||::|
Zfish   275 KDLCNVEDVCDEFTSRHSLEWKFLFLDHRASPIIGYLPFEVLGTSGYDYYHVDDLELIAQCHKQL 339

  Fly   320 RQTGEGKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKE-GQKS 383
            .|.|:||||||||||||||||||||.||::|||:||||:::||||.|||||||..:.|:| |.:.
Zfish   340 MQCGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYAEVRAERRREFGLEE 404

  Fly   384 GNSNSITNNGSSKVI------ASTGTSSKSASATTTLRDFELSSQNLDSTLLGNSLASLGTETAA 442
            .:|:..|::...:.:      ....|..:..||.:      :|||:          :...:.||.
Zfish   405 SSSDMATSSIKGQEVFLDMCPPLEATRDRINSARS------VSSQS----------SRKSSHTAL 453

  Fly   443 TSPAVDSSPMWSASAVQPSGSCQINPLKTSRPASSYGNISSTGISPKAKRKCYFYNNRGNDSDST 507
            :..|.:||..::.:......|..|.|.|:|      ..::.||.....:|:        :.|:..
Zfish   454 SDSASNSSVRYTEACTSSRQSASIGPEKSS------NRMTHTGTKTLIQRQ--------SSSEPP 504

  Fly   508 SMSTDSVTSRQSMMTHVSSQSQRQRSHHREHHRENHHNQSHHHMQQQQ---QHQNQQQQHQQHQQ 569
            |:|..  .|:.|.||                       ||.:..||.|   .||.::|..::.:.
Zfish   505 SLSPS--CSQHSAMT-----------------------QSLYSFQQPQLGVMHQLKEQLEERTRI 544

  Fly   570 L------QQQLQHTVGTPKMVPLLPIASTQIMAGNACQFP-QPAYPLASPQLVAPTFLEPPQYLT 627
            |      |||..|.:...     |.:|:.|::    .|.| |..:..:.||...|
Zfish   545 LQADIKTQQQELHDIKEK-----LQLANLQML----LQQPIQGEFAGSGPQQQGP---------- 590

  Fly   628 AIPMQPVIAPFPVAPVLSPLPVQSQTDMLPDTVV------MTPTQSQLQDQLQRKHDELQKLILQ 686
                              ..|.|..|...|...|      :.|..|..|.|        |:|:
Zfish   591 ------------------GRPAQQNTHPKPQHCVSHSSHTLQPNSSSTQGQ--------QRLV-- 627

  Fly   687 QQNELRIVSEQL----LLSRYTYLQPMMSMGFAPGNMTAAAVGNLGASGQRGLNFTGSNAVQPQF 747
            |...::.||..:    .|:...|..|||   |:|.:            |.|.
Zfish   628 QAGHMQAVSVPMQTHTSLTTPFYSNPMM---FSPNH------------GHRS------------- 664

  Fly   748 NQYGFALNSEQMLNQQDQQMMMQQQQNLHTQHQHNLQQQHQSHSQLQQHTQQQ---HQQQQQQQQ 809
                                            ||:...|..:|:...|..|.:   :|..|...|
Zfish   665 --------------------------------QHDTHCQRNTHADYSQDGQLRMLLNQPMQTLVQ 697

  Fly   810 QQQQQQQQQQ-----QQQQQQQQQQQQQQQLQLQQQNDILLREDIDDIDAFLNLSPLHSLGSQST 869
            ......|..|     ||.:...:||.......:||.|          .:|.|..||:.   :...
Zfish   698 DSNGGPQSSQCTSTIQQTKYPLEQQMMAPSFPVQQVN----------CNAVLVPSPVF---TSPI 749

  Fly   870 INPFNSSSNNNNQSYNGGSNLNNGNQNNNNRSSNPPQNNNEDSL-LSCMQMATESSPSINFHMGI 933
            :.|.||...               :|.....:::||...:  || |...|...:..|....|
Zfish   750 MIPHNSFIT---------------HQTTPTYTTHPPVAPH--SLPLQQPQQFFQMQPQGLIH--- 794

  Fly   934 SDDGSETQSEDNKMMHT------SGSNLVQQQQQQQQQQQILQQHQQQSNSFFSSNPFLNSQNQN 992
               |:.||:    :.||      |....||.||||||||   ..|..||.:.          :..
Zfish   795 ---GTPTQA----LFHTPSVPQQSTVGYVQPQQQQQQQQ---HHHHSQSGNL----------SDY 839

  Fly   993 QNQLP 997
            :|.||
Zfish   840 RNMLP 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	37/76 (49%)
		PAS	93..153	CDD:214512	21/59 (36%)
		PAS_11	265..368	CDD:464214	79/102 (77%)
npas2	NP_840084.1	bHLH-PAS_PASD1	34..103	CDD:381579	34/72 (47%)
		PAS	119..>203	CDD:395786	27/83 (33%)
		PAS_11	286..388	CDD:464214	79/101 (78%)