Protein Alignment Clk and clockb

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_840080.3
• Gene: clockb / 352927
• ZFINID: ZDB-GENE-030408-2
• Length: 821
• Species: Danio rerio
• Alignment Length: 909
• Identity: 301/909 - (33%)
• Similarity: 437/909 - (48%)
• Gaps: 199/909 - (21%)

  Fly     4 ESDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSSRKMDKSTVLKSTIAFLKNHNEA 68
            |.|:||..|    |.|||.||||||||||.|:.:|..::..::|||||||:|:.:|.:|:.:.|.
Zfish    17 EEDEKDKAK----RVSRNKSEKKRRDQFNVLIKELGTMLPGNTRKMDKSTILQKSIDYLRKNKEN 77

  Fly    69 TDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNM 133
            ..:|:..:|:|||||.||||:|::.||||:||||.:|..:.|.|.|.|||:||.|.:||.||.:.
Zfish    78 AAQSESSDIKQDWKPPFLSNEEFSQLMLEALDGFFLVMLTDGYIIYISESVTSLLEHLPSDLMDQ 142

  Fly   134 TIYDLAYEMDHEALLNIFMNPTPVIEPRQTD-ISSSNQITFYTHLRRGGMEKVDANAYELVKFVG 197
            .:.:....:||..:... ::..|.||...:| :.|.||:.|..|:.||.::......||.|||:|
Zfish   143 NLLNFLPVVDHGEVYKA-LSSQPDIENLNSDYLKSKNQMEFCCHMLRGSVDPKKPPVYEYVKFIG 206

  Fly   198 YFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSIIDP 262
            .|::..|    ...:..||..|       |.|.:.....|.:|.|:.|.|:..||.|:||.:::.
Zfish   207 NFKSLVN----MPQKTRNGLEG-------ILQHSLQPAFDDQLCFIATVRLAKPQFIKEMCMVEE 260

  Fly   263 TSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGEGKS 327
            .:.||||:||:|||||.||||||||||||||||||||||||||.|||.|:..|||.|.|.|:|||
Zfish   261 PNEEFTSRHSLEWKFLLLDHRAPPIIGYMPFEVLGTSGYDYYHVDDLHSLAKCHEHLMQFGKGKS 325

  Fly   328 CYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKE-----------GQ 381
            |||||||||||||||||:||::|||:||:|:::||||.|||||||..:.|:|           ..
Zfish   326 CYYRFLTKGQQWIWLQTNYYITYHQWNSRPEFIVCTHTVVSYAEVRAERRREMGIEESPPELTAD 390

  Fly   382 KSGNSNSITNNGSSKVIASTGTSSKSASATTTLRDFELSSQNLDSTLLGNSLASLGTETAATSPA 446
            |...|.:..||...||:.   ..|.|.|.:|:.|....||.           .::...|..::|:
Zfish   391 KISGSETQLNNSLKKVLE---RFSDSRSPSTSSRSSHKSSH-----------TAISDNTCTSTPS 441

  Fly   447 -----VDSSPMWSASAVQPSGSCQINPLKTSRPASSYGNISSTGISPKAKRKCYFYNNRGNDSDS 506
                 |.|||                     |||:         :...::|:
Zfish   442 KLHMDVSSSP---------------------RPAT---------VDMISQRR------------- 463

  Fly   507 TSMSTDSVTSRQSMMTHVSSQSQRQRSHHREHHRENHHNQSH----------HHMQQQQQHQ--- 558
            :|:||.|::|:.:..|....|..:|..|.::..::....|.:          .|:::|.:.:
Zfish   464 SSVSTQSMSSQNTTQTDSPVQISQQTQHQQQQPQQPQQVQPNALFSAQLNAMQHLKEQLEQRTRM 528

  Fly   559 ---NQQQQHQQHQQLQQQLQHTVGTPKMV--------------PLLPIASTQIM----------- 595
               |.|:|.::.:|:.:|||...| |:|:              |.:..|...|:
Zfish   529 IEANIQKQQEELRQIHEQLQRVQG-PQMILQQPAQGGGPSVQLPQVGGAQNNILGIGTQASVVAI 592

  Fly   596 ----------AGNACQ---FPQPAYPLASPQLVAPTFLEP--PQYLTAIPMQPVIA-----PFPV 640
                      :|:|.|   .||...|.:..|.:..:.:..  |.|.|.:..||..|     |..:
Zfish   593 QGQNVTSTAHSGSAPQQQTLPQQQTPRSLQQNLQSSSVTQCGPVYNTMMISQPANANVVQIPSNL 657

  Fly   641 APVLSP------LPVQSQ------TDMLPDTVVMTPTQSQLQDQLQRKHDELQKLILQQQNELRI 693
            ||.:|.      .|...|      |..:....||.|| |....|:...:..    ..|||.:.:.
Zfish   658 APKISQANAINRFPAGQQLVTKIVTAPMACGAVMVPT-SMFMGQVVTAYSP----FTQQQGQTQT 717

  Fly   694 VSEQLLLSRYTYLQPMMSMGFAPGNMTAAAVGNLGASGQRGLNFTGSNAVQPQFNQYGFALNSEQ 758
            ::.|        .||.:.   |.....||.:    .|.|:|.....:...||       .|.|.:
Zfish   718 ITLQ--------TQPTVP---ADQQTQAATL----QSQQQGATQQSTKQQQP-------FLQSTR 760

  Fly   759 MLN-QQDQQMMMQ----QQQNLHTQHQHNLQQQHQSHSQLQQHTQQQHQQQQQQQQQQQQQQQQ 817
            :|: .|..|:::|    |||:..|..|   |||.|...||:.|||:..:.....|......|.|
Zfish   761 LLHGNQPTQLILQAFPIQQQSTFTPSQ---QQQQQQQQQLKPHTQKPQKTASSHQTDSASAQSQ 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	35/74 (47%)
		PAS	93..153	CDD:214512	24/59 (41%)
		PAS_11	265..368	CDD:464214	80/102 (78%)
clockb	NP_840080.3	None