DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clk and tai

DIOPT Version :9

Sequence 1:	NP_001014576.1	Gene:	Clk / 38872	FlyBaseID:	FBgn0023076	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001245949.1	Gene:	tai / 34242	FlyBaseID:	FBgn0041092	Length:	2047	Species:	Drosophila melanogaster

Alignment Length:	1612	Identity:	299/1612 - (18%)
Similarity:	478/1612 - (29%)	Gaps:	677/1612 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KDDTKSFLCRKSRNL--SEKKRRDQFNSLVNDLSALISTSSR------KMDKSTVLKSTIAFLK- 63
            |.|:|..|.:...|.  :||:||:..|..:..||.:::.:.|      |.||:.:|...:...:
  Fly   226 KTDSKVNLPQSQINKCNNEKRRREAENGYIEQLSEILTLNKRGDMTSTKPDKAAILNQVVRTYRE 290

  Fly    64 -------------------------------NHNE--------------ATDRSKVFEIQQDW-- 81
                                           |:|.              |||...:..:||..
  Fly   291 ICDKGQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTRCSRCATDNCSIHPVQQGEVS 355

  Fly    82 -------KPAFLSN-----DEYTHLMLESLDG---FMMVFSSMGSIFYASESITSQLGYLPQDLY 131
                   :|:.|..     ..|...:...:.|   .::..::.|.|...:::|...:||..|:||
  Fly   356 STEPPLPEPSLLLGQVPEISAYFEALEHYISGVGWVLLQVNANGIIESCTQNIRDLIGYEKQELY 420

  Fly   132 NMTIYDLAYEMDH---EALLN-IFMNPT-----------PVIEPRQT---------DISSSNQIT 172
            :..:|...|..||   |.::| ::.||.           |......|         ::::.|...
  Fly   421 HQPLYMYLYSGDHAKLEPIINTMYNNPNGGNSNSANNSGPGGSSAGTSAGVWGDLEELNNGNASQ 485

  Fly   173 FYTHLRRGGM-----------EKVDANAYELVKFVGYFRNDTNTSTGSSSE-------------- 212
            .......||:           ..:......|||       ||.|:|.:||.
  Fly   486 GSNSSGAGGLGGAGGAAAGKKRSISTKVRMLVK-------DTRTATQTSSNCEEKPLRQSGHQDK 543

  Fly   213 ----------VSNGSNGQPAVLPRI----------------FQQNPNAEVDKKLVFVGTGRVQNP 251
                      |.:.::...:||..|                .||.|..::..||...|
  Fly   544 YEEVVLIAAPVKDDADASSSVLCLITRPEDESPLEINIQQHVQQQPIEQMTFKLDIHG------- 601

  Fly   252 QLIREMSIIDPTS-NEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVAC 315
                ::..:|||: .|...:|...|                    :|....|..|..||.::.:.
  Fly   602 ----KILTLDPTALREPFKQHLQTW--------------------VGRLWQDLCHPHDLSTLKSH 642

  Fly   316 HEELRQT--------GEGKSCYYR----FLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVS 368
            ..:::.:        |.|.|...|    .|.....::.::.:..:..:|...:.|:::....:::
  Fly   643 LRDIQDSASANSPGAGAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQTLLN 707

  Fly   369 -----------------------------------YAEVLKDSRKEGQKSGNSNSITNNG----- 393
                                               .:.:..|....|..||:|:|...:|
  Fly   708 SENDMNSSNTGAGSGGLGLGQLCAMAPSPSLASSLLSSLSMDGLHGGTGSGSSSSPAASGMLPTH 772

  Fly   394 ----------------------------SSKVIASTG-------------TSSKSASATTTLRDF 417
                                        ||.:|..||             :||.|:||...:..|
  Fly   773 LLGGLVGGGQQGGGGNSTQTTSVGGPLMSSAIINGTGLQQQQQQQQRSGASSSASSSANALVNAF 837

  Fly   418 ELSSQNLDSTLLGNSLASLGTETAATSPAVDSSP-----MWSASAVQPSGSCQI-NPLKTSRPAS 476
            ..|....:.:..|:.  :...:.||.|.:.:..|     .|:.|  :|:....: .|:.|.||.|
  Fly   838 TASPAPAEHSFYGSD--TFEFDIAAHSSSFELDPSGGVGAWTDS--RPNSRASVATPVSTPRPPS 898

  Fly   477 SYGNISSTGISPKAKRKCYFYNNRGNDSDSTSMSTDSVTSRQS-------------MMTHVSSQS 528
            .:|...:...||....:.            :|.|..|:.|.||             ..:..||..
  Fly   899 GHGFSPAVCASPATPYQL------------SSHSAASLPSPQSNASAGGGNYGGFNFHSFDSSDV 951

  Fly   529 QRQRSHHREHHRENHHNQSH-------------------HHMQQQQQHQNQQQQHQQHQQLQQQL 574
            :.::...::.:::..:|.|.                   ...|||||...||||.||.|:..::|
  Fly   952 KPEKDVQQQQNQQQSNNNSSSSNPLLGGGLPNGVGGMLLSQQQQQQQTPPQQQQQQQQQESSERL 1016

  Fly   575 QHT---------------------------------------------------------VGTPK 582
            :|.                                                         ||...
  Fly  1017 RHLLTKSQSMAGGLGGLGDDEKYFKPEGSEEEKHASGGFKMGGQPGGMGMFGPMGSMGRGVGNSS 1081

  Fly   583 MV--------PLL-------------------------------------PIASTQIMAGNAC-- 600
            |:        |:|                                     |...:..|..|:.
  Fly  1082 MLHKAGNSQNPMLLKLLNEKSEDDDGNGSGGGPGSMNNSRQSELMRQLKNPDGGSHGMHRNSASG 1146

  Fly   601 ------------------------------------QFPQPAYPLASPQLVAPTFLEPPQYLTAI 629
                                                ...:|:......:::|.....||:    |
  Fly  1147 NMSTEDLKAMLKIQSDPSLNRKRSLNEPDDDPSAKRSEDKPSKLCTQNKMLAKLLQNPPK----I 1207

  Fly   630 PMQPVIAPFPVAPVLSPLPVQSQTDMLPDTVVMT------------------------PTQSQLQ 670
            |.    ||.|.    .||.|::..|:...||..|                        ..|.|.|
  Fly  1208 PK----APNPE----QPLQVKTLPDITSSTVSSTLAAPGNLISAGSTGPKAAANRNRKQQQQQQQ 1264

  Fly   671 DQLQRKHDELQKLILQQQNE------LRIVSEQLLLSRYTYLQPMMSMGFAPGNMTAAAVGNLGA 729
            .|.|::..::..:..|||.:      |....:|.|.|.....|.......|..::|.||..:..|
  Fly  1265 QQQQQQQQQVAGIPSQQQQQQPNDVYLSQQQQQQLQSPQLAFQHQQLATTATTSITTAASTSAAA 1329

  Fly   730 SGQRGLNFTGSNAVQPQFN---QY--------------GFALNSEQ---ML--------NQQDQQ 766
            :....:...|.:.:....:   :|              ..|:|..|   ||        |..:||
  Fly  1330 AAAAAILGEGDSELSKLLDSVMEYYPDDTPIVTNAPSEASAINDIQKSLMLDVESAAFGNDLNQQ 1394

  Fly   767 MMMQQQQNLHTQHQHNLQQQHQSHSQLQQHTQQQHQQQQQQ----------QQQQQQQQQQQQQQ 821
            :||.|||    |||...|||.....||.|..|||.||..||          ||||.||||||.||
  Fly  1395 LMMTQQQ----QHQQQQQQQQLLALQLAQQQQQQRQQHLQQPPAYPGMLNMQQQQHQQQQQQNQQ 1455

  Fly   822 ---------------------------------------------QQQ-----QQQQ----QQQQ 832
                                                         |||     ||||    ||::
  Fly  1456 HIMQRLEAMRNQGNQGFQRPPPMYPARGRGPMNAVATPGGVVLPAQQQLRNIRQQQQLAAAQQKE 1520

  Fly   833 QQLQLQQQNDILLREDIDDIDAFLNLSPLHSLGSQSTINPFNSSSNNNNQSYNGGSNLN-----N 892
            :.||.||:..:|:.|:..:.....||..:..|.....:...|:..||.      ||.||     |
  Fly  1521 RLLQQQQKQQLLVPENASEYWGNSNLQLIIKLIVSYILAGMNAGLNNI------GSLLNTTGAPN 1579

  Fly   893 GNQNNNNRSSNPPQNNNEDSLLSCMQMATESS------PSINFHMGISDDGSETQSEDNKMMHTS 951
            .:.:..|..|:...:.|....|...|::...|      |:..:.......|.....:..:
  Fly  1580 VSLSRTNLPSDAQLSPNFAQTLMQQQLSPGRSAPYSPQPNQGYAPQFPQPGQRLSPQQQQ----- 1639

  Fly   952 GSNLVQQQQQQQQQQQILQQHQQ-----QSNSFFSSNPFLNS---QNQNQ-------------NQ 995
              .|.||||...||||:..|.||     :||:.|.||..:.|   ||..|             ..
  Fly  1640 --QLSQQQQNNVQQQQLAYQQQQVGDGGRSNTPFGSNSGMQSPGMQNSPQQWGSGGGGGGGPGGP 1702

  Fly   996 LPN----------------DLE-ILPY---QMSQEQSQNLFNSP-HTAPGSS 1026
            ||:                .|: :.||   |..|.|.:.| ||| ...||.:
  Fly  1703 LPSGNAGRTLQQHNPMLIAQLQGVSPYNARQYQQNQRRGL-NSPGAVGPGGN 1753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	15/105 (14%)
		PAS	93..153	CDD:214512	15/66 (23%)
		PAS	264..366	CDD:238075	15/114 (13%)
		PAS_11	265..368	CDD:291273	15/114 (13%)
tai	NP_001245949.1	HLH	235..286	CDD:238036	13/50 (26%)
		PAS	377..442	CDD:214512	15/64 (23%)
		PAS_11	591..711	CDD:291273	21/150 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900