DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clk and gce

DIOPT Version :9

Sequence 1:	NP_001014576.1	Gene:	Clk / 38872	FlyBaseID:	FBgn0023076	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001188593.1	Gene:	gce / 32457	FlyBaseID:	FBgn0261703	Length:	959	Species:	Drosophila melanogaster

Alignment Length:	696	Identity:	145/696 - (20%)
Similarity:	260/696 - (37%)	Gaps:	166/696 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RKSRNLSEKKRRDQFNSLVNDLSAL---ISTSSRKMDKSTVLKSTIAFLKNHNEATDRSKVFEIQ 78
            |::||.:||.|||:.|..:.:||.:   ::.|.|::||:.||:.....|:
  Fly   279 REARNRAEKNRRDKLNGSIQELSTMVPHVAESPRRVDKTAVLRFAAHALR--------------- 328

  Fly    79 QDWKPAF-----LSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTIYDL 138
              .|.||     ....:.|..:::.||.|.:..:..|.|...|.||...||:...|||..:|..:
  Fly   329 --LKHAFGNSLMQQRPQITDTLMDMLDSFFLTLTCHGHILLISASIEQHLGHCQSDLYGQSIMQI 391

  Fly   139 AYEMDHEALLNIFMNPTPVI-------------EPRQTDISSSNQI---------TFYTHLRRGG 181
            .:..| :.:|...:.||.:.             ||||...:..:.|         :|...|.|.|
  Fly   392 THPED-QNMLKQQLIPTELENLFDAHGDSDAEGEPRQRSKAEEDAIDRKLREDRRSFRVRLARAG 455

  Fly   182 MEKVDANAYELVKFVGYFRNDTNTSTG-------SSSEVSNGSNGQPAVLPRIFQQNPNAEVDKK 239
             .:.:..|||:||..|.||.......|       |:.::...:.|:..|:|.      :......
  Fly   456 -PRSEPTAYEVVKIDGCFRRSDEAPRGVRSNHFSSNLQLIRRTRGRDDVIPL------HTISGND 513

  Fly   240 LVFVGTGRVQNPQLIREMSIIDPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYY 304
            ::..|..|:..|..|.. .:||..:.|:.::|.::.:.:..|.|...:.|||..||...|.:.:.
  Fly   514 IILTGCARIIRPPKIAS-RLIDANTLEYKTRHLIDGRIIDCDQRIGIVAGYMTDEVRNLSPFTFM 577

  Fly   305 HFDDLDSIVACHEELRQTGEGKSCY----YRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHK 365
            |.||:..::..   |||..:..|.|    ||..|:....|:||:..|:...:..:|....||.:.
  Fly   578 HNDDVRWVIVA---LRQMYDCNSSYGESTYRLFTRNGNIIYLQSKGYLEIDKETNKVHSFVCVNT 639

  Fly   366 VVSYAE------------------------------------------VLKDSRKEGQKSGNSNS 388
            ::...|                                          ::::.:|.|:..|:
  Fly   640 LLGEEEGKRRVQEMKKKFSVIINTQIPQSTIDVPASEHPALLEKAVLRLIQNLQKSGENGGH--- 701

  Fly   389 ITNNGSSKVIASTGTSSK------SASATTTLRDF--ELSSQNLDSTLLGNSLASLGTETAATSP 445
              ::|.....|..|...:      ......::.:|  ...|.:..|....::|:|.|...|.|.|
  Fly   702 --DDGDEDDDAQDGDDDEEDDDDDQDDGARSMSEFGDPYGSHHGRSHHGSSALSSHGHGNAKTPP 764

  Fly   446 AVDSSPMWSASAVQPSGSCQINPLKTSRPASSYGNISSTGI-SPKAKRKCYFYNNRG-----NDS 504
            .....|  .||:|:.:.:..|:.:..:......|..:||.: ||.:...|...::..     ..:
  Fly   765 LALVPP--EASSVKSAITKSISVVNVTAAKHLRGIHASTAVKSPSSLGSCTCSDSHSPCDFCQGA 827

  Fly   505 DSTSMSTDSVTSRQSMMTHVSSQSQRQR-----SHHREHHRENHHNQSHHHMQQQQQ-------- 556
            .:|.:.......::....||.::.:..:     |...||......:|...::.||..
  Fly   828 PTTDLQAVGSNLKRGSTAHVETEEKLSKRRFIPSTEIEHVLHTSLDQIGRNLTQQLNVARNLREQ 892

  Fly   557 -------HQNQQ-----QQHQQHQQL--------QQQLQHTVGTPK 582
                   |.||:     |:||:..:|        :.||||...|.|
  Fly   893 SQRYELPHANQRFDEIMQEHQKQSELYVNIKSEYEVQLQHKASTRK 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	18/53 (34%)
		PAS	93..153	CDD:214512	16/59 (27%)
		PAS	264..366	CDD:238075	28/105 (27%)
		PAS_11	265..368	CDD:291273	28/106 (26%)
gce	NP_001188593.1	HLH	279..325	CDD:238036	17/45 (38%)
		PAS	352..>405	CDD:238075	16/53 (30%)
		PAS_11	539..646	CDD:291273	28/109 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444971
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740