Protein Alignment Clk and Npas2

DIOPT Version :9

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_038939510.1
• Gene: Npas2 / 316351
• RGDID: 1309681
• Length: 855
• Species: Rattus norvegicus
• Alignment Length: 952
• Identity: 301/952 - (31%)
• Similarity: 425/952 - (44%)
• Gaps: 263/952 - (27%)

  Fly     1 MDDESDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSSRKMDKSTVLKSTIAFLKNH 65
            ||:  |:||..|    |.|||.||||||||||.|:.:||:::..::||:||:|||:..|.||:.|
  Rat     1 MDE--DEKDRAK----RASRNKSEKKRRDQFNVLIKELSSMLPGNTRKLDKTTVLEKVIGFLQKH 59

  Fly    66 NEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLP--- 127
            ||.:.::::.:|||||||:||||:|:|.||||:||||::|.::.|||.|.|:|||..||:||
  Rat    60 NEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFVIVVTTDGSIIYVSDSITPLLGHLPGTE 124

  Fly   128 ------------------------------------QDLYNMTIYDLAYEMDHEALLNIFMNPTP 156
                                                .|:.:..:.:...|.:|..:..|..:...
  Rat   125 EESMKGLHRSRTLRLCLRSEVHPVERASFSLYFLLQSDVMDQNLLNFLPEQEHSEVYKILSSHML 189

  Fly   157 VIE-PRQTDISSSNQITFYTHLRRGGMEKVDANAYELVKFVGYFRNDTNTSTGSSSEVSNGSNGQ 220
            |.: |....:.|.|.:.||.||.||.:...:...||.:||||.||:..|..:.|.:...| :..:
  Rat   190 VTDSPSPEFLKSDNDLEFYCHLLRGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDN-TLSR 253

  Fly   221 PAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSIIDPTSNEFTSKHSMEWKFLFLDHRAP 285
            |..:|          :.|::.|:.|.|:..||.::||.:.|....||||:||:||||||||||||
  Rat   254 PCRVP----------LGKEVCFIATVRLATPQFLKEMCVADEPLEEFTSRHSLEWKFLFLDHRAP 308

  Fly   286 PIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGEGKSCYYRFLTKGQQWIWLQTDYYVSY 350
            |||||:||||||||||||||.|||:.:..||:.|.|.|:||||.|||||||||||||||.||::|
  Rat   309 PIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITY 373

  Fly   351 HQFNSKPDYVVCTHKVVSYAEVL------------------------KDSRKEGQ---------K 382
            ||:||||:::||||.|||||:|.                        |||..|.|         .
  Rat   374 HQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPTEAMHPSALKEKDSSLEPQPHFNALDMGA 438

  Fly   383 SGNSNSITNNGSSKVIASTGTSSKSASATTTLRDFELSSQNLDSTL-----LGNSLASLGTETAA 442
            ||.::|.:.:.||:   |:..||.:|.:..|....:|.::|..:.|     |...|...|...||
  Rat   439 SGLTSSPSPSASSR---SSHKSSHTAMSEPTSTPTKLMAENSTTALPRSATLPQELPVQGLSQAA 500

  Fly   443 TSPAVDSSPMWSASAVQPSGSCQINPLKTSRPASSYGNISSTGISPKAKRKCYFYNNRGNDSDST 507
            |.||    |:.|:|      ||.:  .|...|.|....:..:..:|..:....|
  Rat   501 TMPA----PLLSSS------SCDL--AKQLLPQSLPQTVLQSPPAPVTQFSAQF----------- 542

  Fly   508 SMSTDSVTSRQSMMTHVSSQ-SQRQRSHHREHHRENHHNQSHHHMQQQQQHQNQQQ--------- 562
                       ||...:..| .||.|.           .|::...||::.|:.|:|
  Rat   543 -----------SMFQTIKDQLEQRTRI-----------LQANIRWQQEELHKIQEQLCLVQDSNV 585

  Fly   563 -------------QHQQHQQLQQQLQHTVGTPKMVPL-----LP--IASTQIMAGN--------A 599
                         ...|....||.||.....|...||     ||  |.|||:...:        :
  Rat   586 QMFLQQPAVSLSFSGAQRPAAQQPLQQRPSAPSQPPLVVNTPLPGQITSTQVTNQHLLRESNVMS 650

  Fly   600 CQFPQPAYPLASPQLVAPTFLEPPQYLTAIPMQPVIAPFPVAPVLSPLPVQSQTDMLP-----DT 659
            .|.|:   |:.|.||:..:    .:.|:::|.|                ..|...:||     .|
  Rat   651 AQGPK---PIRSSQLLPAS----SRSLSSLPSQ----------------FSSTASVLPPGLSLTT 692

  Fly   660 VVMTPTQ-SQLQDQLQRKHDELQKLILQQQNELRIVSEQLLLSRYTYLQPMMSMGFAPGNMTAAA 723
            |..||.. ||.|......||...:|:|.|.                 :||||     ||:..|..
  Rat   693 VAPTPQDTSQCQPSPDFGHDRQLRLLLSQP-----------------IQPMM-----PGSCDARQ 735

  Fly   724 VGNLGASGQRGLNFTGSNAVQPQFNQY--------------------GFALNSEQMLN----QQD 764
            ...:..:| |.:.:..|....|..:.:                    ||..:....|.    ||.
  Rat   736 PSEVSRTG-RQVKYAQSQVTFPSPDSHPTSSSAPTPVLLMGQAVLHPGFPASQPSPLQPTQVQQQ 799

  Fly   765 QQMMMQQQQNLHTQHQHNL------QQQHQSHSQLQQHTQQQ 800
            ....:|...:||::...:|      ||.........|.||.|
  Rat   800 PPPYLQAPTSLHSEQPDSLLLSTFSQQPAPLGYAATQPTQPQ 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	29/51 (57%)
		PAS	93..153	CDD:214512	25/98 (26%)
		PAS	264..366	CDD:238075	77/101 (76%)
		PAS_11	265..368	CDD:291273	78/102 (76%)
Npas2	XP_038939510.1	bHLH-PAS_NPAS2_PASD4	1..77	CDD:381580	41/81 (51%)
		PAS	84..234	CDD:395786	43/149 (29%)
		PAS_11	288..391	CDD:405306	78/102 (76%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338226
Domainoid	1	1.000	199	1.000	Domainoid score	I2971
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1595
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002532
OrthoInspector	1	1.000	-	-		otm45836
orthoMCL	1	0.900	-	-		OOG6_105251
Panther	1	1.100	-	-	O	PTHR46055
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1900
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.750