Protein Alignment Clk and Ncoa1

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_017449617.1
• Gene: Ncoa1 / 313929
• RGDID: 1309046
• Length: 1443
• Species: Rattus norvegicus
• Alignment Length: 1445
• Identity: 270/1445 - (18%)
• Similarity: 457/1445 - (31%)
• Gaps: 542/1445 - (37%)

  Fly     2 DDESD----DKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTS-------SRKMDKSTVL 55
            |..||    |....|...|....:.:||:||:|.|..:.:|:.|:|.:       |.|.||..:|
  Rat     6 DSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKIL 70

  Fly    56 KSTI------AFLKNHNEATD----RSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMG 110
            |.|:      ..::.....||    :|.:....|    ..:..:....|:||:||||..|.:..|
  Rat    71 KKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQ----GVIEKESLGPLLLEALDGFFFVVNCEG 131

  Fly   111 SIFYASESITSQLGYLPQDLYNMTIYDLAYEMDH-EALLNIFMNPTPVIE--PRQTDISSSNQIT 172
            .|.:.||::||.|||..::|.|.::|.:.:..|| |.:.|:.  |..::.  |...:.:..|..|
  Rat   132 RIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLL--PKSLVNGVPWPQEATRRNSHT 194

  Fly   173 FYTHL-----RRGGMEKVDA-NAYELVKFVGYFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQN 231
            |...:     ...|.|..:| ..||:::..                    :..||..:     |.
  Rat   195 FNCRMLIHPPDEPGTENQEACQRYEVMQCF--------------------TVSQPKSI-----QE 234

  Fly   232 PNAEVDKKLVFVGTGRVQNPQLIREMSIIDPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVL 296
            ...:....|:.:.. |:..|..|..:       ..|.:|.....|.:.:|..:        ....
  Rat   235 DGEDFQSCLICIAR-RLPRPPAITGV-------ESFMTKQDTTGKIISIDTSS--------LRAA 283

  Fly   297 GTSGYDYYHFDDLDSIVAC------------------HEELRQTGEGKSCYYRFLTKGQQWIWLQ 343
            |.:|::       |.:..|                  .:|:...|...|..|||:......:...
  Rat   284 GRTGWE-------DLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAH 341

  Fly   344 TDYYVSYHQFNSKPDYVVCTHKV-----------------------------------VSYAEVL 373
            |...:.|.|......:::..|.:                                   |:.:..|
  Rat   342 TKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRINPSVNPGISPAHGVTRSSTL 406

  Fly   374 KDS-------RKEGQK-------SGNSNSITNNGS------SKVIASTGTSSKSASATTTLRDFE 418
            ..|       |...|:       |.:|||.::.||      ::::||...|...|.:.::.....
  Rat   407 PPSNNNMVSARANRQQSTDLNSGSSHSNSSSSQGSFGCSPGNQIVASVALSQGQAGSQSSNPSLN 471

  Fly   419 LSSQNLDSTLLGNSLASLGTETAATSPAVDSSPMWSASAVQP------------SGSCQIN---- 467
            |::..::.|  |.|||...:.....:..:.:....|.::..|            ||:|..|
  Rat   472 LNNSPMEGT--GISLAQFMSPRRQANSGLATRARMSNNSFPPNIPTLSSPVGITSGACSNNNRSY 534

  Fly   468 ---PLKTSRPASSYGNISSTGIS----------------------PKAKRK-------------- 493
               |: ||....:.|..:|.|.|                      .||:.|
  Rat   535 SNIPV-TSLQGMNEGPNNSVGFSAGSPVLRQMSSQNSPSRLSMQPAKAESKDNKEIASILNEMIQ 598

  Fly   494 --------------CYFYNNRGNDSDS-------------------------------------- 506
                          ....|:|.:|.||
  Rat   599 SDNSANEGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTG 663

  Fly   507 TSMSTDSVTSRQSMMTHVSSQSQRQRSHHR---------------EHHRENHHNQSHHHMQQQQQ 556
            ||.|..|..|..:..:..||.::|.:..||               |..:::..:.| ..|....|
  Rat   664 TSSSASSNPSGGTCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPEKKDSASAS-TAMSVSGQ 727

  Fly   557 HQ-----------NQQQQHQQHQQLQQQLQHTVGTPKMVPLLPIASTQIMAGNACQF----PQPA 606
            .|           :::::.:.||.|:..|.......:..|.|.:...::......|.    ..||
  Rat   728 AQGSASIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPA 792

  Fly   607 YPLASP---------------------QLV--------APTFLEPPQYLTAIP------------ 630
             |:..|                     ||:        .|...|..:...|:|
  Rat   793 -PVTKPAPEEVKLESQSQFSADLDQFDQLLPTLEKAAQLPGLCETDRMDGAVPGVNIKSEILPAS 856

  Fly   631 MQPVIAPFPVAPVLSPLP------VQSQ------TDMLP--DTVVMTPTQSQLQDQ--------- 672
            :||  .|...||.|:.||      :.:|      .|.:|  :..|....||:.:||
  Rat   857 LQP--TPARSAPRLNRLPELELEAIDNQFGQPGAGDQIPWANNTVTAINQSKPEDQCISSQLDEL 919

  Fly   673 ------LQRKHDE---LQKLI----------------------LQQQNELRIVSEQ--------- 697
                  ::.::||   |::|:                      |.|...|.::||:
  Rat   920 LCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSERFPPQQATPP 984

  Fly   698 -LLLSRYT-YLQPMMSMGFAPGNMTAAAVG----------NLG-----ASGQRGLNFTGSNAVQP 745
             ::..|.| |.||     ::..:.||...|          :||     .:..|| .|:.:..:||
  Rat   985 LMMEDRPTLYPQP-----YSSPSPTAGLSGPFQGMVRQKPSLGTMPVQVTPPRG-TFSPNMGMQP 1043

  Fly   746 Q--FNQYGFALNSEQMLNQQDQQMMMQQQQNLHTQHQHNLQQQHQSHSQLQQHTQQQHQQQQQQQ 808
            :  .|:...|.|   .|..|.||.:..|||.:| |::..:..|..:::.:..:.:...|||...|
  Rat  1044 RQTLNRPPAAPN---QLRLQLQQRLQGQQQLMH-QNRQAILNQFAANAPVGMNMRSGMQQQITPQ 1104

  Fly   809 QQQQQQQQQQQQQQQQQQQQQQQQQQLQLQQQNDILLREDIDDIDAFLNLSPLHSLGSQSTINPF 873
            .....|...|:|::...||.:|:|   .:|||..:|:|.
  Rat  1105 PPLNAQMLAQRQRELYSQQHRQRQ---IIQQQRAMLMRH-------------------------- 1140

  Fly   874 NSSSNNNNQSYNGGSNLNNGN--------------QNNNNRSSNPPQNNNEDSLLSC---MQMAT 921
              .|..||...:.|..:..||              .|.......||.:.:..|.|:.   ..:||
  Rat  1141 --QSFGNNIPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLAT 1203

  Fly   922 ESSPSIN----------FHMGIS-----------DDGSETQSEDN------------KMMHTSGS 953
            .|| .:|          |..|||           ..|...|:|.|            .|.....|
  Rat  1204 RSS-MVNRGMAGNMGGQFGTGISPQMQQNVFQYPGSGLVPQAEANFAPSLSPGSSMVPMPIPPQS 1267

  Fly   954 NLVQQ----QQQQQQQQQILQQHQQQSNSFFS---------SNPFL-------------NSQNQN 992
            :|:||    ...|....:..||....:|:.||         :.|.:             |:..||
  Rat  1268 SLLQQTPPTSGYQSPDMKAWQQGTMGNNNVFSQAVQSQPAPAQPGVYNNMSITVSMAGGNANVQN 1332

  Fly   993 QNQLPNDLEILPYQM 1007
            .|.:...:::...||
  Rat  1333 MNPMMGQMQMSSLQM 1347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	22/91 (24%)
		PAS	93..153	CDD:214512	24/60 (40%)
		PAS_11	265..368	CDD:464214	18/155 (12%)
Ncoa1	XP_017449617.1	bHLH-PAS_NCoA1_SRC1	27..87	CDD:381518	16/59 (27%)
		PAS	120..213	CDD:238075	28/94 (30%)
		PAS_11	259..370	CDD:464214	18/132 (14%)
		NCOA_u2	469..591	CDD:465223	22/124 (18%)
		SRC-1	630..709	CDD:462615	10/78 (13%)
		DUF4927	744..821	CDD:465083	12/77 (16%)
		Nuc_rec_co-act	927..972	CDD:462608	7/44 (16%)
		Med15	<977..>1289	CDD:312941	74/353 (21%)
		DUF1518	1152..1208	CDD:462174	12/56 (21%)
		DUF1518	1215..1270	CDD:462174	10/54 (19%)