DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clk and clocka

DIOPT Version :9

Sequence 1:	NP_001014576.1	Gene:	Clk / 38872	FlyBaseID:	FBgn0023076	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_571032.2	Gene:	clocka / 30140	ZFINID:	ZDB-GENE-990630-14	Length:	892	Species:	Danio rerio

Alignment Length:	964	Identity:	332/964 - (34%)
Similarity:	460/964 - (47%)	Gaps:	212/964 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ESDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSSRKMDKSTVLKSTIAFLKNHNEA 68
            |.|:||..|    |.|||.||||||||||.|:.:|..::..::|||||||:|:.:|.||:.|.|.
Zfish    18 EEDEKDKAK----RVSRNRSEKKRRDQFNVLIKELGTMLPGNTRKMDKSTILQKSIDFLRKHKEI 78

  Fly    69 TDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNM 133
            ..:|:..||:|||||.||||:|:|.||||:||||.:...:.|:|.|.|||:||.|.:||.||.:.
Zfish    79 AAQSESSEIRQDWKPPFLSNEEFTQLMLEALDGFFLAIMTDGNIIYVSESVTSLLEHLPSDLVDQ 143

  Fly   134 TIYDLAYEMDHEAL---LNIFMNPTPVIEPRQTDISSSNQITFYTHLRRGGMEKVDANAYELVKF 195
            .:.:.....:|..:   |:..|.....:.|..  :.:.||:.|..|:.||.::..:...||.|||
Zfish   144 NLLNFLPLGEHSEVYKALSTHMLEGETLTPDY--LKTKNQLEFCCHMLRGTIDPKEPPVYEYVKF 206

  Fly   196 VGYFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSII 260
            :|.|:: .||...|:   .||..|       :.|::.....:.::.|:.|.|:..||.|:||..:
Zfish   207 IGNFKS-LNTVPNST---RNGFEG-------VIQRSLRHAFEDRVCFIATVRLAKPQFIKEMCTV 260

  Fly   261 DPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGEG 325
            :..:.||||:||:|||||||||||||||||:||||||||||||||.|||:::..|||.|.|.|:|
Zfish   261 EEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLETLAKCHEHLMQYGKG 325

  Fly   326 KSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKE----------- 379
            |||||||||||||||||||.||::|||:||:|:::||||.|||||||..:.|:|
Zfish   326 KSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAEQRRELGIEESPPEIS 390

  Fly   380 ---GQKSGNSNSITNNGSSKVI----------ASTGTSSKSASATTTLRDFELSSQNLDSTLLGN 431
               .|.||:.:.:..:...:.:          ||:.:|.||:|.|.      :|......|.|
Zfish   391 ADKSQDSGSESQLNTSSLKEALERFDHSRTPSASSRSSRKSSSHTA------VSDPTSTQTKL-- 447

  Fly   432 SLASLGTETAATSPAVDSSPMWSASAVQPSGSCQINPLKTSRPASSYGNISSTGISPKAKRKCYF 496
                   :|..::|     |..|.||::          .||:..||.
Zfish   448 -------QTDRSTP-----PRQSVSAIE----------MTSQRRSSI------------------ 472

  Fly   497 YNNRGNDSDSTSMSTDSVTSRQSMMTHVSSQSQRQRS------------------HHREHHRENH 543
                      :|.|..|.|:.|:|.|.:.||.|:.::                  .|.:...|..
Zfish   473 ----------SSQSMSSQTTGQTMGTSLVSQPQQPQTLQATVQPVLQFSTQMDAMQHLKEQLEQR 527

  Fly   544 HNQSHHHMQQQQQHQNQQQ---QHQQHQQLQQQLQHTVGTPKMVPLLPIASTQIMAGNACQFPQP 605
            ......::|:||:...|.|   |..|.|.||..||.:.|.      |.::|.|:...::.   |.
Zfish   528 TRMIEANIQRQQEELRQIQDELQRVQGQGLQMFLQPSGGG------LNLSSVQLTQSSSV---QT 583

  Fly   606 AYPLASPQLVAPT-FLEPPQYLTAIPMQPVIAPFPVAPVL-------------------SPLPVQ 650
            |..|:....|.|| .|:.....|....|..:...|....:                   |...:|
Zfish   584 AGTLSMQGAVVPTATLQSSLQSTHSSTQHTVTQHPQQTAVQQQNLLRDQTTNLNQQSQRSTHTLQ 648

  Fly   651 SQTDMLPDTVVMT-----PTQS---QLQDQLQRKHDELQKLI--LQQQNELRIVSEQLLLSRYTY 705
            |....||.::..|     |||:   |:...|.:........:  ..|..::|..:.|.||::..
Zfish   649 SPQGALPASLYNTMMISQPTQANVVQISTSLAQNSSTSGAAVATFSQDRQIRFPATQQLLTKLV- 712

  Fly   706 LQPM----------MSMG-----FAP---------------------GNMTAAAVGNLGASGQRG 734
            ..||          |.||     |||                     ...|.|.......:.|:|
Zfish   713 TGPMACGAVMVPTTMFMGQVVTAFAPQQGQPQTISIAQQPSAQTADQQTHTQAQTQAAATAQQQG 777

  Fly   735 LNFTGSNAVQPQFNQYGFALNSEQMLNQQDQQMMMQ-----QQQNLHTQHQHNLQQQHQSHSQLQ 794
            .|.......|.||.|....|:|     .|..|:::|     |||...|.   ..|||.|.|.|.|
Zfish   778 QNQAQLTQQQTQFLQAPRLLHS-----NQSTQLILQAAFPLQQQGTFTT---ATQQQQQLHQQQQ 834

  Fly   795 QHTQQQHQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQLQQQNDILLRED 848
            |..|||..||||||||||.|||.||||||.|||.|||||||...:.:.:..|.:
Zfish   835 QLQQQQQLQQQQQQQQQQLQQQHQQQQQQLQQQHQQQQQQLAAHRSDSMTERSN 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	28/51 (55%)
		PAS	93..153	CDD:214512	23/62 (37%)
		PAS	264..366	CDD:238075	78/101 (77%)
		PAS_11	265..368	CDD:291273	79/102 (77%)
clocka	NP_571032.2	HLH	23..77	CDD:238036	30/57 (53%)
		PAS	100..>169	CDD:279347	26/68 (38%)
		PAS	109..207	CDD:238075	31/99 (31%)
		PAS_11	265..368	CDD:291273	79/102 (77%)
		PAS	266..364	CDD:238075	76/97 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	198	1.000	Domainoid score	I3029
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	446	1.000	Inparanoid score	I1606
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002532
OrthoInspector	1	1.000	-	-		otm24250
orthoMCL	1	0.900	-	-		OOG6_105251
Panther	1	1.100	-	-	O	PTHR46055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4514
SonicParanoid	1	1.000	-	-		X1900
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.850