Protein Alignment Clk and Npas3

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_036013330.1
• Gene: Npas3 / 27386
• MGIID: 1351610
• Length: 1247
• Species: Mus musculus
• Alignment Length: 931
• Identity: 173/931 - (18%)
• Similarity: 324/931 - (34%)
• Gaps: 278/931 - (29%)

  Fly    18 KSRNLSEKKRRDQFNSLVNDLSALI---STSSRKMDKSTVLKSTIAFLKNHNEATDRSKVFEIQ- 78
            |||: :.:.||.:.|....:|:.|:   :..:.::||:::::.||::||..:.|......:.::
Mouse   364 KSRD-AARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRM 427

  Fly    79 ------------QDWK--------------------PAFLSNDEY-THL---MLESLDGFMMVFS 107
                        |.||                    |:.|:.:.: .||   :|:|||||:...:
Mouse   428 EGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALN 492

  Fly   108 SMGSIFYASESITSQLGYLPQDLYNMTIYDLAYEMDH-EALLNIFMNPTP--------VIEPRQT 163
            ..|...|.||:::..||....:|...:::|..:..|| |....:.|...|        ..|...:
Mouse   493 QEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTTEDAAS 557

  Fly   164 DISSSNQ--------------------------ITFYTHLRRGGMEKVDANAYELVKFVGYFRND 202
            ..|||:|                          |...:.|.:.|:. :.::.|:::...|..|..
Mouse   558 SASSSSQSETPEPVETTSPSLLTTDNTLERSFFIRMKSTLTKRGVH-IKSSGYKVIHITGRLRLR 621

  Fly   203 TNTSTGSS--SEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSIIDPTSN 265
            .:.|.|.:  |::..                        ||.|  .....|..|.|:.|   ..:
Mouse   622 VSLSHGRTVPSQIMG------------------------LVVV--AHALPPPTINEVRI---DCH 657

  Fly   266 EFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGEGKSCYY 330
            .|.::.:|:...::.::|....:...|.:::|...|.:.|.:|::.|...|.:|...|:..:.||
Mouse   658 MFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYY 722

  Fly   331 RFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEV------------LKDSRKEGQKS 383
            |::.|...:||:|:...::.:..|:....::..:.::|..|.            |.:...|..::
Mouse   723 RWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKASESSET 787

  Fly   384 GNSNSITNNGSSKVIASTGTSSKS-----------------------------------ASATTT 413
            .:|.| .:..:|.:.|....:|||                                   :|:...
Mouse   788 SDSES-DSKDTSGITAEDNENSKSDEKGNQSENSEDPEPDRKKSGSACDNDMNCNDDGHSSSNPD 851

  Fly   414 LRDFELSSQNLD---STLLGNSLASLGTETAATSPAVDSSPMWSASAVQPSGSCQINPLKTSRPA 475
            .||.:.|.::.|   .....:...:||.........|:|.   :...:||..|...:..|.|..|
Mouse   852 SRDSDDSFEHSDFEHPKAAEDGFGALGPMQIKVERYVESE---ADLRLQPCESLTSDSAKDSDSA 913

  Fly   476 SSYGNISSTGISPKAKRKCYFYNNRGNDSDSTSMSTDS--------VTSRQSMMTHVSSQSQRQR 532
            :..|..:|   |...|||......:|..:....:|:.|        |...:.:.:..|:...:.:
Mouse   914 NEAGAQAS---SKHQKRKRRRKRQKGGSASRRRLSSASSPGLDAGLVEPPRLLSSPHSASVLKIK 975

  Fly   533 SHHRE--------------HHRENHHNQSHHHMQQ--QQQH----QNQQQQHQQHQQLQQQLQHT 577
            :...|              .:||...|:|.:.|.:  ..:|    |.|.........|...:..:
Mouse   976 TEIAEPINFDNDSSIWNYPPNREISRNESPYSMTKPPTSEHFPSPQGQGGSSGGGGALHVAIPDS 1040

  Fly   578 VGTPKMVPLLPIASTQIMAGNACQF----PQPAYPLASPQLVAPTFLEP----------PQYLTA 628
            |.||      |.|..  .||...||    |.|:.||:.|...:|....|          |....:
Mouse  1041 VLTP------PGADG--TAGRKTQFSGTAPVPSDPLSPPLSASPRDKHPGGGAGSGGGGPGASNS 1097

  Fly   629 I-------PMQPVIAPFPVAPVLSPLPVQSQTDMLPDTVVMTPTQSQLQDQLQRKHDELQKLILQ 686
            :       .:|.:.|...|.|::         ..:..|:..|.|.:|
Mouse  1098 LLYTGDLEALQRLQAGNVVLPLV---------HRVTGTLAATSTAAQ------------------ 1135

  Fly   687 QQNELRIVSEQLLLSRYTYLQPMMSMGFAPGNMTAAAVGNLGASGQRGLNFTGSNAVQPQFNQYG 751
                 |:         ||    ..::.:||..:|.|..||| ......:||.       ..|..|
Mouse  1136 -----RV---------YT----TGTIRYAPAEVTLAMQGNL-LPNAHAVNFV-------DVNSPG 1174

  Fly   752 FALNSE---QMLNQQDQQMMM 769
            |.|:.:   :||.....::.|
Mouse  1175 FGLDPKTPMEMLYHHVHRLNM 1195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	19/103 (18%)
		PAS	93..153	CDD:214512	19/63 (30%)
		PAS_11	265..368	CDD:464214	20/102 (20%)
Npas3	XP_036013330.1	bHLH-PAS_NPAS3_PASD6	357..433	CDD:381575	15/69 (22%)
		PAS	478..536	CDD:214512	17/57 (30%)
		PAS_3	669..756	CDD:430001	18/86 (21%)
		MSCRAMM_ClfA	<790..991	CDD:468110	34/207 (16%)