Protein Alignment Clk and Bmal2

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_006507111.1
• Gene: Bmal2 / 272322
• MGIID: 2684845
• Length: 595
• Species: Mus musculus
• Alignment Length: 524
• Identity: 125/524 - (23%)
• Similarity: 229/524 - (43%)
• Gaps: 119/524 - (22%)

  Fly    17 RKSRNLSEKKRRDQFNSLVNDLSALIS---TSSRKMDKSTVLKSTIAFLKNHNEATDRSKVFEIQ 78
            |::.:..||:|||:.|.|:..||::|.   .::.|:||.:||:..:.:|::....|:    ..:.
Mouse    50 REAHSQMEKRRRDKMNHLIQKLSSMIPPHIPTAHKLDKLSVLRRAVQYLRSLRGMTE----LYLG 110

  Fly    79 QDWKPAFLSNDEYTHLMLESLDGFMMVFS-SMGSIFYASESITSQLGYLPQDLYNMTIYDLAYEM 142
            ::.||:|:.:.|.:||:|::.:||:.|.. ..|.|||.|:|::..|.|....|....::|
Mouse   111 ENSKPSFIQDKELSHLILKAAEGFLFVVGCERGRIFYVSKSVSKTLRYDQASLIGQNLFD----- 170

  Fly   143 DHEALLNIFMNPTPVIE----------PRQTDI-SSSNQITFYTHLRRGGM-------------- 182
                    |::|..|.:          ||:..| :.::|:..:.:..|..|
Mouse   171 --------FLHPKDVAKVKEQLSCDGSPREKPIDTKTSQVYSHPYTGRPRMHSGSRRSFFFRMKS 227

  Fly   183 ---------------EKVDANAYELVKFVGYFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNP 232
                           :|.|...:..|...||.|:......|...|...|.:..|..
Mouse   228 CTVPVKEEQPCSSCSKKKDHRKFHTVHCTGYLRSWPLNVVGMEKESGGGKDSGPLT--------- 283

  Fly   233 NAEVDKKLVFVGTGRVQNPQLIREMS-IIDPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVL 296
                    ..|..||: :|.::.:.| .|:....||.::.:|..||:::|.||..|:||:|.|:|
Mouse   284 --------CLVAMGRL-HPYIVPQKSGKINVRPAEFITRFAMNGKFVYVDQRATAILGYLPQELL 339

  Fly   297 GTSGYDYYHFDDLDSIVACHEELRQTGEG-KSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYV 360
            |||.|:|:|.||..|:...|:.:.|:.|. .:..|:|..|...::.|:::::...:.:..:.:|:
Mouse   340 GTSCYEYFHQDDHSSLTDKHKAVLQSKEKILTDSYKFRVKDGAFVTLKSEWFSFTNPWTKELEYI 404

  Fly   361 VCTHKVVSYAEVLKDSRKEGQKS-----GNSNSITNNGSSKVIASTGTSSKSASATTTLRDFELS 420
            |..:.:|.       .|.|.:.|     |:|.|  :.|.:::....|.|..|:.:      |..|
Mouse   405 VSVNTLVL-------GRSETRLSLLHCGGSSQS--SEGKTELQVRRGNSDASSDS------FRQS 454

  Fly   421 SQNLDSTLLGNSL--ASLGTETA----------ATSPAVDSSPMWSASAVQPSGSCQINPLKTSR 473
            ..|:.....|..|  .|:||:.|          ::||. |:||     :.:....|.:|......
Mouse   455 CINVPGVSTGTVLGAGSIGTDIANEVLSLQRLHSSSPE-DASP-----SEEVRDDCSVNGGNAYG 513

  Fly   474 PASS 477
            |||:
Mouse   514 PAST 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	20/71 (28%)
		PAS	93..153	CDD:214512	17/60 (28%)
		PAS_11	265..368	CDD:464214	32/103 (31%)
Bmal2	XP_006507111.1	bHLH_SF	49..108	CDD:469605	18/61 (30%)
		PAS	125..184	CDD:214512	19/71 (27%)
		PAS_11	309..411	CDD:464214	32/101 (32%)