Protein Alignment Clk and sim1a

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_835740.2
• Gene: sim1a / 260351
• ZFINID: ZDB-GENE-020829-1
• Length: 745
• Species: Danio rerio
• Alignment Length: 882
• Identity: 189/882 - (21%)
• Similarity: 321/882 - (36%)
• Gaps: 251/882 - (28%)

  Fly    18 KSRNLSEKKRRDQFNSLVNDLSALI---STSSRKMDKSTVLKSTIAFLKNHNEATDRSKVFE--I 77
            ||:| :.:.||::.||...:|:.|:   |..:.::||:::::.|.::||       ...||.  :
Zfish     4 KSKN-AARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLK-------MRIVFPEGL 60

  Fly    78 QQDW----KPAFLSN---DEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTI 135
            .:.|    :...|.|   :..:|| |::||||:.|.:..|.|.|.||:.:..||....:|...:|
Zfish    61 GESWGHVSRTTSLENVGRELGSHL-LQTLDGFIFVVAPDGKILYISETASVHLGLSQVELTGNSI 124

  Fly   136 YDLAYEMDHEALL---------------------NIFMNPTPVIEPRQTDISSSNQITFYTHLRR 179
            |:..:..||:.:.                     :.|:....|:..|...::...    |..:..
Zfish   125 YEYIHPADHDEMTAVLTAHQPYHSHFVHEYEMERSFFLRMKCVLAKRNAGLTCGG----YKVIHC 185

  Fly   180 GGMEKVDANAYELVKFVGYFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVG 244
            .|..|:...:.::..|.|.::|....:.|.|             ||      |:|..:.||
Zfish   186 SGYLKIRQYSLDMSPFDGCYQNVGLVAVGHS-------------LP------PSAVTEIKL---- 227

  Fly   245 TGRVQNPQLIREMSIIDPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDL 309
                              .||.|..:.|::.|.:|||.|...:.||.|.:::..:.|.:.|..|.
Zfish   228 ------------------HSNMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHSCDT 274

  Fly   310 DSIVACHEELRQTGEGKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLK 374
            ..:...|..|...|:..:.|||||.|...|:|:|:...:.::..:|:|      |.:||...||.
Zfish   275 FHLRCAHHLLLVKGQVTTKYYRFLAKQGGWVWVQSYATIVHNSRSSRP------HCIVSVNYVLT 333

  Fly   375 DSRKEG------QKSGNSNSITNNGSSKVIAS---TGTSSKSASAT-TTLRDF--------ELSS 421
            |:..:|      |.:....|.|.|..|..:..   .|.|..|.:.| |.|..:        :.|.
Zfish   334 DTEYKGLQLSLDQAASTKPSFTYNSPSNPVTENRRVGKSRVSRTKTKTRLSPYSQYPGFPTDRSE 398

  Fly   422 QNLDSTLLGNSLASLGTETAATSP-------AVDSSPMWSASAVQPSGSCQINPLKTSRPASSYG 479
            .:.||...|:.|      |.:.||       .::||.::...: .|...|...||......|:
Zfish   399 SDQDSPWGGSPL------TDSASPQLLEQCEGIESSCVYRQFS-DPRSLCYGLPLTEDHHTSN-- 454

  Fly   480 NISSTGISPKAKRKC-----YFYNNRGNDSDS-----------TSMSTDSVTSRQSMMTHVSS-Q 527
            .:.|...|...:|.|     ||........::           ...|.::..|.:.:|.|::| .
Zfish   455 ELYSHPHSESCERGCCKAGRYFLGTPQPGREAWWGAARSVLPLPKSSPENGDSFEGVMPHIASIH 519

  Fly   528 SQRQRSHHREHHREN-----HHNQSHHHMQQQQQHQNQQ------------QQHQQHQQLQQQLQ 575
            |.:.|.|..|....:     ..:.|....:..|...:.|            ||..:.::.:.||:
Zfish   520 SLQVRGHWDEDSAVSSPDGGSASDSGDRFRADQCRSSPQEPSKIETLIRATQQMIKEEESRLQLR 584

  Fly   576 HTVGTPKMVPLLPIASTQIMAGNACQFPQPAYPLASPQLVAPTFLEPPQYLTAIPMQPVIAPFPV 640
            .   .|..|||.| .::...:.::..|||.|                        ||.|:...|
Zfish   585 K---LPTDVPLEP-TNSLAKSFHSTDFPQSA------------------------MQSVVCRGP- 620

  Fly   641 APVLSPLPVQSQTDMLPDTVVMTPTQSQLQDQLQRKHDELQKLILQQQNELRIVSEQLLLSRYTY 705
            |.|:||         .|..|.::...|.|.|:|.:..|.|       ||||.  |.||.|
Zfish   621 AQVISP---------APSPVPLSRLSSPLPDRLSKGKDFL-------QNELS--SSQLPL----- 662

  Fly   706 LQPMMSMGFAPGNMTAAAVGNLGASGQRGLNFTGSNAVQPQFNQYGFALNSEQMLNQQDQQMM-- 768
                                            ||:.||.|....|  :|:..|.|.:.....:
Zfish   663 --------------------------------TGTCAVSPTPALY--SLHPRQYLEKHAAYSLTS 693

  Fly   769 --MQQQQNLHTQHQHNLQQQHQSHSQLQQHTQQQHQQ 803
              ::......:...::|.....||..:..|.:.|.:|
Zfish   694 YALEHLYEADSFRGYSLGCSGSSHYDMTTHLRMQAEQ 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	18/76 (24%)
		PAS	93..153	CDD:214512	21/80 (26%)
		PAS_11	265..368	CDD:464214	29/102 (28%)
sim1a	NP_835740.2	bHLH-PAS_SIM1	1..71	CDD:381581	18/74 (24%)
		PAS	88..>158	CDD:238075	17/69 (25%)
		PAS_3	243..329	CDD:430001	27/91 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..413		16/68 (24%)
		SIM_C	358..647	CDD:461963	67/335 (20%)
		Nuclear localization signal. /evidence=ECO:0000250	368..387		6/18 (33%)