DRSC/TRiP Functional Genomics Resources

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Protein Alignment Clk and Ahr

DIOPT Version :10

Sequence 1:NP_001014576.1 Gene:Clk / 38872 FlyBaseID:FBgn0023076 Length:1027 Species:Drosophila melanogaster
Sequence 2:NP_037281.3 Gene:Ahr / 25690 RGDID:2074 Length:853 Species:Rattus norvegicus


Alignment Length:854 Identity:176/854 - (20%)
Similarity:306/854 - (35%) Gaps:277/854 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 KKRRDQFNSLVNDLSALISTSS---RKMDKSTVLKSTIAFLK--------------NHNEATD-- 70
            |:.||:.|:.::.|::|:....   .|:||.:||:.::::|:              :.:...|  
  Rat    36 KRHRDRLNTELDRLASLLPFPQDVISKLDKLSVLRLSVSYLRAKSFFDVALKSTPADRSRGQDQC 100

  Fly    71 RSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTI 135
            |::|    :||:.  |...|:   :|::|:||::|.::...:||||.:|...||:...|:.:.::
  Rat   101 RAQV----RDWQD--LQEGEF---LLQALNGFVLVVTADALVFYASSTIQDYLGFQQSDVIHQSV 156

  Fly   136 YDLAYEMDH---EALLNIFMNPTPVIEPRQTDISSSNQITFYTHLRRGGMEKVDANAYELVKFVG 197
            |:|.:..|.   :..|:..:||:...:..|                  |:::    .:.|.:...
  Rat   157 YELIHTEDRAEFQRQLHWALNPSQCTDSAQ------------------GVDE----THGLPQPAV 199

  Fly   198 YFRND----TNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVG---TGRV-----QN 250
            |:..|    .||                |.:.|.|:......:|....|:.   .||:     ||
  Rat   200 YYTPDQLPPENT----------------AFMERCFRCRLRCLLDNSSGFLAMNFQGRLKYLHGQN 248

  Fly   251 ----------PQL--------IREMSIIDPTSNE--FTSKHSMEWKFLFLDHRAPPIIGYMPFEV 295
                      |||        ::..||::..:..  |.:||.:::..:..|.:...|:||...|:
  Rat   249 KKGKDGALLPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGQLILGYTEVEL 313

  Fly   296 LGT-SGYDYYHFDDLDSIVACHEELRQTGEGKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDY 359
            ... |||.:.|..|:......|..:.:|||.....:|.|.|..:|.|:|::..:.|.  |.:|||
  Rat   314 CNKGSGYQFIHAADMLHCAESHIRMIKTGESGMTVFRLLAKHSRWRWVQSNARLIYR--NGRPDY 376

  Fly   360 VVCTHKVVSYAEVLKDSRKEGQKSGNSNSIT-------------------------------NNG 393
            ::.|.:.:        :.:||::.....|:|                               :|.
  Rat   377 IIATQRPL--------TDEEGREHLQKRSMTLPFMFATGKAVLYEISSPFSPIMDPLPIRTKSNT 433

  Fly   394 SSKVIASTGTSSKSASATTTL------RDFEL------SSQNLDSTLLGNSLASLGTETAATSPA 446
            |.|..|...|.||.:....:|      :|..:      |...|||..|.:|::..|:        
  Rat   434 SRKDWAPQSTPSKDSFHPNSLMSALIQQDESIYLCPPSSPAPLDSHFLMDSMSECGS-------- 490

  Fly   447 VDSSPMWSASAVQPSGSCQI--NPLKTSRPASSYGNISSTGISPKAKRKCYFYNNRGND------ 503
                  |..|....|....:  ..::.::..    |::.:| .|..    .|.:|:.||      
  Rat   491 ------WQGSFAAASNEALLKHEEIRHTQDV----NLTLSG-GPSE----LFPDNKNNDLYSIMR 540

  Fly   504 ------SDSTSMS------TDS--------VTSRQSMMTHV-----------SSQSQRQRSHHRE 537
                  .|..||.      |||        :.....::|:|           |:..|:..|.|..
  Rat   541 NLGIDFEDIRSMQNEEFFRTDSSGEVDFKDIDITDEILTYVQDSLNNSTLLNSACQQQPVSQHLS 605

  Fly   538 HHRENHHNQSHHHMQQQQQHQNQQQQHQQHQQLQQQL------QHTVG--TPKMVPLLPIASTQI 594
                   ......:|.:||.|.|||...|..:.|:||      ||.:|  |..|         |:
  Rat   606 -------CMLQERLQLEQQQQLQQQHPTQTLEPQRQLCQVEVPQHELGQKTKHM---------QV 654

  Fly   595 MAGNACQFPQPAYPLASPQLVAPTFLEPPQYLTAIPMQPVIAPFPVAPVLSPLPVQSQTDMLPDT 659
            ....|...|.|....:.||      .|...|.....:|.....|         |.:|:.|.:|.|
  Rat   655 NGMFASWNPAPPVSFSCPQ------QERKHYSLFSGLQGTAQEF---------PYKSEVDSMPYT 704

  Fly   660 VVMTPTQSQL--------------QDQLQRKHDELQKL-----ILQQQNELR--IVSEQLLLSRY 703
            ....|....|              :|..:..|.....|     .||.....|  |.|:..::|..
  Rat   705 QNFAPCNQSLLPEHSKGTQLDFPGRDFERSLHPNASNLEDFVSCLQVPENQRHGINSQSAMVSPQ 769

  Fly   704 TYLQPMMSM 712
            .|....|||
  Rat   770 AYYAGAMSM 778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClkNP_001014576.1 bHLH-PAS_dCLOCK 11..86 CDD:381578 17/79 (22%)
PAS 93..153 CDD:214512 17/62 (27%)
PAS_11 265..368 CDD:464214 29/105 (28%)
AhrNP_037281.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..38 1/1 (100%)
Nuclear localization signal 1. /evidence=ECO:0000250|UniProtKB:P35869 12..15
bHLH-PAS_AhR 27..87 CDD:381442 12/50 (24%)
Nuclear localization signal 2. /evidence=ECO:0000250|UniProtKB:P35869 36..41 2/4 (50%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:P35869 37..65 6/27 (22%)
Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P35869 49..81 8/31 (26%)
Nuclear export signal. /evidence=ECO:0000250|UniProtKB:P35869 63..71 4/7 (57%)
PAS 111..>181 CDD:395786 20/72 (28%)
Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P30561 116..124 3/7 (43%)
Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P30561 264..266 0/1 (0%)
PAS_3 295..380 CDD:430001 25/86 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..451 7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

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