DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clk and Arnt2

DIOPT Version :9

Sequence 1:	NP_001014576.1	Gene:	Clk / 38872	FlyBaseID:	FBgn0023076	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_036913.3	Gene:	Arnt2 / 25243	RGDID:	2154	Length:	712	Species:	Rattus norvegicus

Alignment Length:	680	Identity:	147/680 - (21%)
Similarity:	255/680 - (37%)	Gaps:	176/680 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDDESDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSS---RKMDKSTVLKSTIAFL 62
            ||.:.:|.:....| .|::.:..|::||::....:.:||.::.|.|   ||.||.|:|:..::.:
  Rat    50 MDFDDEDGEGPSKF-SRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHM 113

  Fly    63 KN----HNEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSS-MGSIFYASESITSQ 122
            |:    .|::||.:        :||:||:..|..||:||:.|||:.|.:: .|.:.|.|:|:|..
  Rat   114 KSMRGTGNKSTDGA--------YKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPV 170

  Fly   123 LGYLPQDLYNMTIYDLAYEMDHEALLNIFMNPTPVIEPRQTDISSS------------------- 168
            |.....:.:..|:|:..:..|.|.|..........:..|..|:.:.
  Rat   171 LNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRR 235

  Fly   169 ------------------NQITFYTHLRRGGMEKVDAN--AYELVKFVGYFRNDTNTSTGSSSEV 213
                              |:||......|.|:..|...  .|.:|...||.:
  Rat   236 SFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIK------------- 287

  Fly   214 SNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQ---NPQLIREMSIIDPTSNEFTSKHSMEW 275
                 ..|.....|.:::.:.....|...|..||:|   :|..:....:..||  ||.|:|:.:.
  Rat   288 -----AWPPAGMSIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMSGMSVPT--EFLSRHNSDG 345

  Fly   276 KFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQT----GEGKSCYYRFLTKG 336
            ...|:|.|...:|||.|.::||....::.|.:|...:   .|..:|.    |:..|..|||.||.
  Rat   346 IITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHL---RESFQQVVKLKGQVLSVMYRFRTKN 407

  Fly   337 QQWIWLQTDYYVSYHQFNSKPDYVVCTH------------------------------------- 364
            ::|:.::|..:...:.::.:.:||:||:
  Rat   408 REWLLIRTSSFTFQNPYSDEIEYVICTNTNVKQLQQQQAELEVHQRDGLSSYDLSQVPVPNLPTG 472

  Fly   365 -----KVVSYAEVL----KDSRKEGQKSGNS-------NSITNNGSSKVIAS-----TGTSSKSA 408
                 |.|..|:.:    :|.|.....:|.|       :|.:.:||.::.:.     .|.|.|:.
  Rat   473 VHEAGKPVEKADAIFSQERDPRFAEMFAGISASEKKMMSSASASGSQQIYSQGSPFPAGHSGKAF 537

  Fly   409 SATTT----LRDFELSS---QNLDSTLLGNSLASLGTETAATSPAVDSSPMWSASAVQPSGSCQI 466
            |::..    :.|.:.||   ||:..  :...|.........:.|.....|..:.|:....||...
  Rat   538 SSSVVHVPGVNDIQSSSSTGQNISQ--ISRQLNQGQVAWTGSRPPFPGQPSKTQSSAFGIGSSHP 600

  Fly   467 NPLKTSRPASSYGNISSTGISPKAKRKCYFYNNRGNDSDSTSMSTDSVTSRQSMMTHVSSQSQRQ 531
            .|    ...|||..:||...|..:...   |.:..|.:...:.|..|....|...:.|.||.|.|
  Rat   601 YP----ADPSSYSPLSSPAASSPSGNA---YPSLANRTPGFAESGQSGGQFQGRPSEVWSQWQSQ 658

  Fly   532 RSHHREHHRENHHNQSHHHMQQQQQHQNQQ 561
                            ||..|..:||.:||
  Rat   659 ----------------HHGQQSGEQHSHQQ 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	16/58 (28%)
		PAS	93..153	CDD:214512	19/60 (32%)
		PAS	264..366	CDD:238075	30/147 (20%)
		PAS_11	265..368	CDD:291273	31/148 (21%)
Arnt2	NP_036913.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..74		6/24 (25%)
		bHLH-PAS_ARNT	62..124	CDD:381517	17/62 (27%)
		PAS	137..243	CDD:395786	22/105 (21%)
		PAS_11	336..436	CDD:405306	30/102 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	573..712		29/123 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338230
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740