DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clk and Arnt

DIOPT Version :9

Sequence 1:	NP_001014576.1	Gene:	Clk / 38872	FlyBaseID:	FBgn0023076	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_036912.3	Gene:	Arnt / 25242	RGDID:	2153	Length:	809	Species:	Rattus norvegicus

Alignment Length:	930	Identity:	200/930 - (21%)
Similarity:	329/930 - (35%)	Gaps:	312/930 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DDESDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSS---RKMDKSTVLKSTIAFLK 63
            |||....|  |..|.|::.:..|::||::..:.:.:||.::.|.|   ||.||.|:|:..::.:|
  Rat    78 DDEQSSAD--KERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK 140

  Fly    64 N----HNEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFS-SMGSIFYASESITSQL 123
            :    .|.:||.|        :||:||::.|..||:||:.|||:.:.| ..|.:.|.|:|:|..|
  Rat   141 SLRGTGNTSTDGS--------YKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVL 197

  Fly   124 GYLPQDLYNMTIYDLAYEMDHEALLNIFMNPTPVIEPRQTDISS----------------SNQIT 172
            .....:.:..|:||..:..|.:.|..........:..|..|:.:                .::.:
  Rat   198 NQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRS 262

  Fly   173 FYTHLRRG--GMEKVDANAYELVKFVGYFRNDTNTSTGSSSEVSNGSNGQP-------------- 221
            |...:|.|  .::.|..|.      :.:.||......||..|      |:|
  Rat   263 FICRMRCGTSSVDPVSMNR------LSFLRNRCRNGLGSVKE------GEPHFVVVHCTGYIKAW 315

  Fly   222 ----AVLPRIFQQNPNAEVDKKLVFVGTGRVQ---NPQLIREMSIIDPTSNEFTSKHSMEWKFLF 279
                ..||   ..:|.|....|...|..||:|   :|......:|..||  ||.|:|::|..|.|
  Rat   316 PPAGVSLP---DDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNICQPT--EFISRHNIEGIFTF 375

  Fly   280 LDHRAPPIIGYMPFEVLGTSGYDYYHFDD----LDSIVACHEELRQTGEGKSCYYRFLTKGQQWI 340
            :|||....:||.|.|:||.:..::.|.:|    .||.   .:.::..|:..|..:||..|.::|:
  Rat   376 VDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSF---QQVVKLKGQVLSVMFRFRAKNREWL 437

  Fly   341 WLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKEGQKSGNSNSITNNGSSKVIASTGTSS 405
            |::|..:...:.::.:.:|::||                     |:| :.|
  Rat   438 WMRTSSFTFQNPYSDEIEYIICT---------------------NTN-VKN-------------- 466

  Fly   406 KSASATTTLRDFELSSQNLDSTLLGNSLASLGTETAATSPAVDSSPMWSASAVQPSGSCQINPLK 470
                          |||....||                          ::.:|.|   |:.|
  Rat   467 --------------SSQEPRPTL--------------------------SNTIQRS---QLGP-- 486

  Fly   471 TSRPASSYGNISSTGISPKAKRKCYFYNNRGNDSDSTSMSTDSVTSRQSMMTHVSSQSQRQRSHH 535
                        :|.:                   |..|.|..:.|||          |:|:
  Rat   487 ------------TTNL-------------------SLEMGTGQLASRQ----------QQQQ--- 507

  Fly   536 REHHRENHHNQSHHHMQQQQQHQNQQQQHQQHQQLQQQLQHTVG-------TPKMVPLLPIASTQ 593
                            |||||.|.||||.||.||.|.:|....|       :...|.:.|:|:
  Rat   508 ----------------QQQQQQQQQQQQQQQQQQQQTELDMVPGRDGLASYSHSQVSVQPVAT-- 554

  Fly   594 IMAGNACQFP------------QPAYPLASPQLVAPTFLEPPQYLTA--IPMQPVI----APFPV 640
              ||:....|            .|.:....|.:.|    :..:.|::  :|....:    :.||.
  Rat   555 --AGSEHSKPLEKSEGLFVQDRDPRFSEIYPNISA----DQSKGLSSSTVPATQQLFSQGSSFPP 613

  Fly   641 APVLSPLPVQS--QTDMLPDTVVMTPTQS--QLQDQLQRKHDELQK---------------LILQ 686
                :|.|.::  .:.:.|...::.|:.|  |:..|:.| |..|.:               ..|.
  Rat   614 ----NPRPAENFRNSGLTPPVTIVQPSSSAGQILAQISR-HSNLTQGSAPTWTSSTRPGFSAQLP 673

  Fly   687 QQNELRIVSEQLLLSRYTYLQPMMSMGFAPGNMTA----AAVGNLGASGQRGLNF---TGSNAVQ 744
            .|...:..|.|..::.:.......:|.. ||..||    ||...|   ..||.||   ||
  Rat   674 TQATAKTRSSQFGVNNFQTSSSFSAMSL-PGAPTASPSTAAYPTL---PNRGSNFPPETG----- 729

  Fly   745 PQFNQYGFALNSEQMLNQQDQQMMMQQQQNLHTQHQHNLQQQHQSHSQLQQHTQQQHQQQQQQQQ 809
                             |...|...:..:.:....|...||.|...|..:||.|....|...|.:
  Rat   730 -----------------QTTGQFQTRTAEGVGVWPQWQGQQPHHRSSSNEQHVQPTSAQPSSQPE 777

  Fly   810 QQQQQQQQQQQQQQQQQQQQ 829
            ..|:.......|......::
  Rat   778 VFQEMLSMLGDQSNTYNNEE 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	16/58 (28%)
		PAS	93..153	CDD:214512	19/60 (32%)
		PAS	264..366	CDD:238075	31/105 (30%)
		PAS_11	265..368	CDD:291273	31/106 (29%)
Arnt	NP_036912.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..95		7/18 (39%)
		bHLH-PAS_ARNT	86..150	CDD:381517	18/63 (29%)
		DNA-binding. /evidence=ECO:0000250\|UniProtKB:P53762	88..128		11/39 (28%)
		Required for heterodimer formation with EPAS1. /evidence=ECO:0000250\|UniProtKB:P53762	112..264		41/159 (26%)
		Required for heterodimer formation with HIF1A. /evidence=ECO:0000250\|UniProtKB:P53762	112..168		21/63 (33%)
		PAS	166..230	CDD:214512	19/63 (30%)
		Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000250\|UniProtKB:P53762	167..171		2/3 (67%)
		PAS_3	373..461	CDD:369881	26/111 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..487		10/92 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..575		6/33 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..685		3/31 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..735		15/61 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..809		12/50 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810