Protein Alignment Clk and Sim2

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_006523029.1
• Gene: Sim2 / 20465
• MGIID: 98307
• Length: 661
• Species: Mus musculus
• Alignment Length: 521
• Identity: 117/521 - (22%)
• Similarity: 206/521 - (39%)
• Gaps: 94/521 - (18%)

  Fly    18 KSRNLSEKKRRDQFNSLVNDLSALI---STSSRKMDKSTVLKSTIAFLK-----NHNEATDRSKV 74
            ||:| :.|.||::.|....:|:.|:   |..:.::||:::::.|.::||     ...||......
Mouse     4 KSKN-AAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGEAAGLGDA 67

  Fly    75 FEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTIYDLA 139
            :.......|......|....:|::||||:.|.:|.|.|.|.||:.:..||....:|...:||:..
Mouse    68 WGQPSRTGPLDSVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYI 132

  Fly   140 YEMDHEALLNIFMNPTPVIEP--RQTDISSSNQITFYTHL------RRGGMEKVDANAYELVKFV 196
            :..||:.:..:.....|:...  ::.:|..|    |:..:      |..|:   ..:.|:::...
Mouse   133 HPSDHDEMTAVLTAHPPLHHHLLQEYEIERS----FFLRMKCVLAKRNAGL---TCSGYKVIHCS 190

  Fly   197 GYFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSIID 261
            ||.:                      :...:...:......:.:..|..|:...|..|.|:.:
Mouse   191 GYLK----------------------IRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKL-- 231

  Fly   262 PTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGEGK 326
             .||.|..:.|::.|.:|||.|...:.||.|.:::..:.|.:.|..|...:...|..|...|:..
Mouse   232 -HSNMFMFRASLDLKLIFLDSRVTELTGYEPQDLIEKTLYHHVHGCDTFHLRYAHHLLLVKGQVT 295

  Fly   327 SCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKV---VSYAEVL----KDSRKEGQKSG 384
            :.|||.|:|...|:|:|:...|.::..:|:|..:|..:.|   |.|.|:.    :.|..:.|:|.
Mouse   296 TKYYRLLSKLGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTDVEYKELQLSLDQVSTSKSQESW 360

  Fly   385 NSNSITNNGSSKVIASTGTSSKSASATTTLRDFELSS---QNLDSTLLGNSLASLGTETAAT--- 443
            .:...|:..:.|......|..|:...|......:.||   ..|:.:.:||...|..|...|.
Mouse   361 RTTLSTSQETRKSAKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECSQVGNWRTSPPTNAVAPPEQ 425

  Fly   444 ---SPAVD---------------------------SSPMWSASAVQPSGS-CQINPLKTSR-PAS 476
               |.|.|                           ..|...|...||.|| |::.....|. |||
Mouse   426 QLHSEASDLLYGPPYSLPFSYHYGHFPLDSHVFSSKKPGLPAKFGQPQGSPCEVARFFLSTLPAS 490

  Fly   477 S 477
            |
Mouse   491 S 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	18/75 (24%)
		PAS	93..153	CDD:214512	19/59 (32%)
		PAS_11	265..368	CDD:464214	30/105 (29%)
Sim2	XP_006523029.1	bHLH_SF	1..78	CDD:469605	18/74 (24%)
		PAS	83..144	CDD:214512	20/60 (33%)
		PAS_11	95..198	CDD:464214	24/131 (18%)
		PAS_3	247..333	CDD:430001	25/85 (29%)
		SIM_C	362..654	CDD:461963	28/130 (22%)