Protein Alignment Clk and Sim1

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_006512689.1
• Gene: Sim1 / 20464
• MGIID: 98306
• Length: 801
• Species: Mus musculus
• Alignment Length: 926
• Identity: 180/926 - (19%)
• Similarity: 319/926 - (34%)
• Gaps: 279/926 - (30%)

  Fly    18 KSRNLSEKKRRDQFNSLVNDLSALI---STSSRKMDKSTVLKSTIAFLKNHNEATDRSKVFEIQQ 79
            ||:| :.:.||::.||...:|:.|:   |..:.::||:::::.|.::||......:....|.:|
Mouse     4 KSKN-AARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEVRCKFRMQ- 66

  Fly    80 DWKPAFL-----------------SNDEYTHL-----------------------MLESLDGFMM 104
              .|.||                 :|.:|..|                       :|::||||:.
Mouse    67 --TPGFLRYSLMGPGISRRKETDSNNSDYLGLGEAWGHTSRTSPLDNVGRELGSHLLQTLDGFIF 129

  Fly   105 VFSSMGSIFYASESITSQLGYLPQDLYNMTIYDLAYEMDHEALL--------------------- 148
            |.:..|.|.|.||:.:..||....:|...:||:..:..||:.:.
Mouse   130 VVAPDGKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIER 194

  Fly   149 NIFMNPTPVIEPRQTDISSSNQITFYTHLRRGGMEKVDANAYELVKFVGYFRNDTNTSTGSSSEV 213
            :.|:....|:..|...::...    |..:...|..|:...:.::..|.|.::|....:.|.|
Mouse   195 SFFLRMKCVLAKRNAGLTCGG----YKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHS--- 252

  Fly   214 SNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSIIDPTSNEFTSKHSMEWKFL 278
                      ||      |:|..:.||                      .||.|..:.|::.|.:
Mouse   253 ----------LP------PSAVTEIKL----------------------HSNMFMFRASLDMKLI 279

  Fly   279 FLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGEGKSCYYRFLTKGQQWIWLQ 343
            |||.|...:.||.|.:::..:.|.:.|..|...:...|..|...|:..:.|||||.|...|:|:|
Mouse   280 FLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKQGGWVWVQ 344

  Fly   344 TDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKEGQKSGNSNSITNNGSSKVIASTGTSSKSA 408
            :...:.::..:|:|      |.:||...||.|:..:|.:.         ...::.||..|.|.::
Mouse   345 SYATIVHNSRSSRP------HCIVSVNYVLTDTEYKGLQL---------SLDQISASKPTFSYTS 394

  Fly   409 SATTTLRDFELSSQNLDSTLLGNSLAS-------LGTETAATSPAVDSSPMWSASAVQPSGSCQI 466
            |:|.|:.|....:::..|:....|..|       ..||.:.:    |....|..|.:..:.|.|:
Mouse   395 SSTPTISDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSES----DHDSQWGGSPLTDTASPQL 455

  Fly   467 NPLKTSRPASSYGNISSTGISPKAKRKCY--------------FYNN------------------ 499
              |...||.|.:....:....|.....||              |:..
Mouse   456 --LDPERPGSQHELSCAYRQFPDRSSLCYGFALDHSRLVEDRHFHTQACEGGRCEAGRYFLGAPP 518

  Fly   500 RGNDS--------DSTSMSTDSVTSRQSMMTHVSSQSQRQRSHHREHHRENHHNQS---HHHMQQ 553
            .|.|.        ..|..|.:|..:.::.|.|::|   ..|.|.|.|..|:....|   ....:.
Mouse   519 TGRDPWWGSRAALPLTKASPESREAYENSMPHITS---IHRIHGRGHWDEDSVVSSPDPGSASES 580

  Fly   554 QQQHQNQQQQHQQHQQLQQQLQHTVGTPKMVPLLPIASTQIM---AGNACQFPQ-PAYPLAS--- 611
            ..:::.:|.|:..|:            |..:..| |.:||.|   ..|..|..: |...|||
Mouse   581 GDRYRTEQYQNSPHE------------PSKIETL-IRATQQMIKEEENRLQLRKAPPDQLASING 632

  Fly   612 ----PQLVAPTFLEPPQYLTAIPMQPVIAPFPVAPVLSPLPVQSQTDMLPDTVVMTPTQSQLQDQ 672
                ..|....:.:||               |...|.....:.|.:..               |.
Mouse   633 AGKKHSLCFANYQQPP---------------PTGEVCHSSALASTSPC---------------DH 667

  Fly   673 LQRKHDELQKLILQQQNEL----------------RIVSEQLLLSRYTYLQPMMSMGFAPGNMTA 721
            :|::..   |::...:|:.                ||....|:|:: .||...||.....|:..|
Mouse   668 IQQREG---KMLSPHENDYDNSPTALSRISSPSSDRITKSSLILAK-DYLHSDMSPHQTAGDHPA 728

  Fly   722 AAVGNLGASGQRGLNFTGSNAVQPQFNQYGFALNSEQMLNQQDQQMMMQQQQNLHTQHQHNLQQQ 786
            .:....|:..|             .|:::.:.|....:.:..|.:.:.......:..|     ..
Mouse   729 ISPNCFGSHRQ-------------YFDKHAYTLTGYALEHLYDSETIRNYSLGCNGSH-----FD 775

  Fly   787 HQSHSQLQQHTQQQHQ 802
            ..||.::|....|.|:
Mouse   776 VTSHLRMQPDPAQGHK 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	18/70 (26%)
		PAS	93..153	CDD:214512	20/103 (19%)
		PAS_11	265..368	CDD:464214	29/102 (28%)
Sim1	XP_006512689.1	bHLH-PAS_SIM1	1..107	CDD:381581	23/106 (22%)
		PAS	124..>194	CDD:238075	17/69 (25%)
		PAS_3	279..365	CDD:430001	27/91 (30%)
		SIM_C	395..704	CDD:461963	63/363 (17%)