Protein Alignment Clk and AHR

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_001612.1
• Gene: AHR / 196
• HGNCID: 348
• Length: 848
• Species: Homo sapiens
• Alignment Length: 869
• Identity: 177/869 - (20%)
• Similarity: 319/869 - (36%)
• Gaps: 259/869 - (29%)

  Fly    25 KKRRDQFNSLVNDLSALISTSS---RKMDKSTVLKSTIAFLK--------------NHNEATDRS 72
            |:.||:.|:.::.|::|:....   .|:||.:||:.::::|:              ..|...|..
Human    37 KRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNC 101

  Fly    73 KVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTIYD 137
            :....::...   |...|:   :|::|:||::|.::...:||||.:|...||:...|:.:.::|:
Human   102 RAANFREGLN---LQEGEF---LLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYE 160

  Fly   138 LAYEMDH---EALLNIFMNPTPVIE-----------PRQTDISSSNQI----------TFYTHLR 178
            |.:..|.   :..|:..:||:...|           |:.....:.:||          .|...||
Human   161 LIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLR 225

  Fly   179 RGGMEKVDANAYELVKFVG---YFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKL 240
               ....:::.:..:.|.|   |..       |...:..:||     :||           .:..
Human   226 ---CLLDNSSGFLAMNFQGKLKYLH-------GQKKKGKDGS-----ILP-----------PQLA 264

  Fly   241 VFVGTGRVQNPQL--IREMSIIDPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGT-SGYD 302
            :|.....:|.|.:  ||..:.|      |.:||.:::..:..|.:...::||...|:... |||.
Human   265 LFAIATPLQPPSILEIRTKNFI------FRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQ 323

  Fly   303 YYHFDDLDSIVACHEELRQTGEGKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVV 367
            :.|..|:......|..:.:|||.....:|.|||..:|.|:|::..:.|.  |.:|||::.|.:.:
Human   324 FIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLYK--NGRPDYIIVTQRPL 386

  Fly   368 SYAEVLKDSRKEGQK------SGN------SNSI----------TNNGSS-KVIASTGTSSKS-- 407
            :..|..:..||...|      :|.      :|..          |.||:| |..|:|.|.||.
Human   387 TDEEGTEHLRKRNTKLPFMFTTGEAVLYEATNPFPAIMDPLPLRTKNGTSGKDSATTSTLSKDSL 451

  Fly   408 --------------------ASATTTLRDFELSSQNLDSTLLGN---SLASLGTETAATSPAVDS 449
                                ||:|::...||.:..|.......|   :.|.:|.:|......:|.
Human   452 NPSSLLAAMMQQDESIYLYPASSTSSTAPFENNFFNESMNECRNWQDNTAPMGNDTILKHEQIDQ 516

  Fly   450 SPMWSASAVQPSGSCQINPLKTSRPASSYGNISSTGIS----PKAKRKCYFYNNRGNDSDSTSMS 510
            ....::.|....|..|     .|:.:..|..:.:.||.    ...:.:.:|.|:...:.|...:.
Human   517 PQDVNSFAGGHPGLFQ-----DSKNSDLYSIMKNLGIDFEDIRHMQNEKFFRNDFSGEVDFRDID 576

  Fly   511 -TDS----VTSRQSMMTHVSSQSQRQRSHHREHHRENHHNQSHHHMQQQQQHQNQQQQHQQHQQL 570
             ||.    |....|....:.|..|:|:|...   ..:...|.|.|::|||||..:|...:..|||
Human   577 LTDEILTYVQDSLSKSPFIPSDYQQQQSLAL---NSSCMVQEHLHLEQQQQHHQKQVVVEPQQQL 638

  Fly   571 QQQLQHTVGTPKMVPLLPIASTQIMAGNACQFPQPAYPLASPQLVAPTFLEPPQY---------- 625
            .|:::|..           .:......|:.||    .|...||      .:|.||
Human   639 CQKMKHMQ-----------VNGMFENWNSNQF----VPFNCPQ------QDPQQYNVFTDLHGIS 682

  Fly   626 --------LTAIPM--------QPVI------------------APFPVAPVLS------PLPVQ 650
                    :.::|.        |||:                  :|:|....|.      .||..
Human   683 QEFPYKSEMDSMPYTQNFISCNQPVLPQHSKCTELDYPMGSFEPSPYPTTSSLEDFVTCLQLPEN 747

  Fly   651 SQTDMLPDTVVMTP--------TQSQLQDQLQRKHDELQKLILQQQNELRIVSEQLLLSRY---- 703
            .:..:.|.:.::||        :..|.|.:.|..|      :.|.|....:..:|..|:::
Human   748 QKHGLNPQSAIITPQTCYAGAVSMYQCQPEPQHTH------VGQMQYNPVLPGQQAFLNKFQNGV 806

  Fly   704 ------------------TYLQPM 709
                              |:|||:
Human   807 LNETYPAELNNINNTQTTTHLQPL 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	14/77 (18%)
		PAS	93..153	CDD:214512	17/62 (27%)
		PAS_11	265..368	CDD:464214	29/103 (28%)
AHR	NP_001612.1	bHLH-PAS_AhR	28..88	CDD:381442	12/50 (24%)
		PAS	113..226	CDD:395786	27/118 (23%)
		PAS_3	297..382	CDD:430001	25/86 (29%)