DRSC/TRiP Functional Genomics Resources

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Protein Alignment Clk and Npas2

DIOPT Version :10

Sequence 1:NP_001014576.1 Gene:Clk / 38872 FlyBaseID:FBgn0023076 Length:1027 Species:Drosophila melanogaster
Sequence 2:NP_032745.2 Gene:Npas2 / 18143 MGIID:109232 Length:816 Species:Mus musculus


Alignment Length:887 Identity:301/887 - (33%)
Similarity:421/887 - (47%) Gaps:196/887 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDDESDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSSRKMDKSTVLKSTIAFLKNH 65
            ||:  |:||..|    |.|||.||||||||||.|:.:||:::..::|||||:|||:..|.||:.|
Mouse     1 MDE--DEKDRAK----RASRNKSEKKRRDQFNVLIKELSSMLPGNTRKMDKTTVLEKVIGFLQKH 59

  Fly    66 NEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDL 130
            ||.:.::::.:|||||||:||||:|:|.||||:||||::|.::.|||.|.|:|||..||:||.|:
Mouse    60 NEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFVIVVTTDGSIIYVSDSITPLLGHLPADV 124

  Fly   131 YNMTIYDLAYEMDHEALLNIFMNPTPVIE-PRQTDISSSNQITFYTHLRRGGMEKVDANAYELVK 194
            .:..:.:...|.:|..:..|..:...|.: |....:.|.|.:.||.||.||.:...:...||.:|
Mouse   125 MDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEFLKSDNDLEFYCHLLRGSLNPKEFPTYEYIK 189

  Fly   195 FVGYFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSI 259
            |||.||:..|..:.|.:...| :..:|..:|          :.|.:.|:.|.|:..||.::||.:
Mouse   190 FVGNFRSYNNVPSPSCNGFDN-TLSRPCHVP----------LGKDVCFIATVRLATPQFLKEMCV 243

  Fly   260 IDPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGE 324
            .|....||||:||:|||||||||||||||||:||||||||||||||.|||:.:..||:.|.|.|:
Mouse   244 ADEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQFGK 308

  Fly   325 GKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKE---------- 379
            ||||.|||||||||||||||.||::|||:||||:::||||.|||||:|..:.|:|          
Mouse   309 GKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVERRQELALEDPPTEA 373

  Fly   380 ---------------------------GQKSGNSNSITNNGSSKVIASTGTSSKSASATTTLRDF 417
                                       |..|..|.|.::..|.|       ||.:|.:..|....
Mouse   374 MHPSAVKEKDSSLEPPQPFNALDMGASGLPSSPSPSASSRSSHK-------SSHTAMSEPTSTPT 431

  Fly   418 ELSSQNLDSTL-----LGNSLASLGTETAATSPAVDSSPMWSASAVQPSGSCQINP--LKTSRPA 475
            :|.::|..:.|     |...|...|...|||.|          :|:..|.||.:..  |..|.| 
Mouse   432 KLMAENSTTALPRPATLPQELPVQGLSQAATMP----------TALHSSASCDLTKQLLLQSLP- 485

  Fly   476 SSYGNISSTGI-SPKAKRKCYFYNNRGNDSDSTSMSTDSVTSRQSMMTHVSSQ-SQRQRSHHREH 538
                   .||: ||.|                   .....:::.||...:..| .||.|.     
Mouse   486 -------QTGLQSPPA-------------------PVTQFSAQFSMFQTIKDQLEQRTRI----- 519

  Fly   539 HRENHHNQSHHHMQQQQQHQNQQQ----QHQQHQQLQQQLQHTVGTPKMVPLLPIASTQIMAGNA 599
                  .|::...||::.|:.|:|    |....|...||       |.:  .|..:|||..|...
Mouse   520 ------LQANIRWQQEELHKIQEQLCLVQDSNVQMFLQQ-------PAV--SLSFSSTQRPAAQQ 569

  Fly   600 CQFPQPAYPLASPQLVAPTFLEPPQYLTAIPMQPVI---------APFP-----VAPV----LSP 646
            ....:||.| :.||||..|.|:.....|.:..|.::         .|.|     :.|.    ||.
Mouse   570 QLQQRPAAP-SQPQLVVNTPLQGQITSTQVTNQHLLRESNVISAQGPKPMRSSQLLPASGRSLSS 633

  Fly   647 LPVQ--SQTDMLP-----DTVVMTP-TQSQLQDQLQRKHDELQKLILQQQNELRIVSEQLLLSRY 703
            ||.|  |...:||     .|:..|| ..||.|......||...:|:|.|.               
Mouse   634 LPSQFSSTASVLPPGLSLTTIAPTPQDDSQCQPSPDFGHDRQLRLLLSQP--------------- 683

  Fly   704 TYLQPMMSMGFAPGNMTAAAVGNLGASGQRGLNFTGSNAVQPQFNQYGFALNSEQMLNQQDQQMM 768
              :||||     ||:..|.....:..:| |.:.:..|..:.|       :.:|....:.....::
Mouse   684 --IQPMM-----PGSCDARQPSEVSRTG-RQVKYAQSQVMFP-------SPDSHPTNSSASTPVL 733

  Fly   769 MQQQQNLHTQHQHN-------LQQQHQSHSQLQQHTQQQHQQ 803
            :..|..||.....:       .|.|.|....||..|....:|
Mouse   734 LMGQAVLHPSFPASRPSPLQPAQAQQQPPPYLQAPTSLHSEQ 775

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClkNP_001014576.1 bHLH-PAS_dCLOCK 11..86 CDD:381578 39/74 (53%)
PAS 93..153 CDD:214512 25/59 (42%)
PAS_11 265..368 CDD:464214 78/102 (76%)
Npas2NP_032745.2 bHLH-PAS_NPAS2_PASD4 1..77 CDD:381580 42/81 (52%)
Sufficient for heterodimer formation with BMAL1, E-box binding and for the effect of NADPH. /evidence=ECO:0000269|PubMed:23831463 1..61 35/65 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 13/25 (52%)
PAS 84..195 CDD:395786 43/110 (39%)
PAS_11 249..352 CDD:464214 78/102 (76%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 364..431 10/73 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..639 8/28 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 685..705 8/25 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 742..816 7/34 (21%)

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