Protein Alignment Clk and hif-1

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_001023891.2
• Gene: hif-1 / 180359
• WormBaseID: WBGene00001851
• Length: 721
• Species: Caenorhabditis elegans
• Alignment Length: 880
• Identity: 177/880 - (20%)
• Similarity: 291/880 - (33%)
• Gaps: 249/880 - (28%)

  Fly    18 KSRNLSEKK---------RRDQFNSLVNDLSALI----STSSRKMDKSTVLK--STIAFLKNHNE 67
            :.||:..::         ||.:.:.:.:||...:    ..:...:|:..:|:  :||..|:.
 Worm     5 RKRNMERRRETSRHAARDRRSKESDIFDDLKMCVPIVEEGTVTHLDRIALLRVAATICRLRK--- 66

  Fly    68 ATDRSKVFEIQQDWKPAFLSNDEYTH-LMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLY 131
              ....|.|...|.:   ::|:.:|. .:.|.||||:|:..|..||.|.:||:...||....||.
 Worm    67 --TAGNVLENNLDNE---ITNEVWTEDTIAECLDGFVMIVDSDSSILYVTESVAMYLGLTQTDLT 126

  Fly   132 NMTIYDLAYEMDHEALLNIFMNPTPVI-EPR--QTDISSSNQITFYTHLR-------RGGMEKVD 186
            ...:.|..:..|::.    |...:.:: :||  .||.:..|.:     ||       ||....:.
 Worm   127 GRALRDFLHPSDYDE----FDKQSKMLHKPRGEDTDTTGINMV-----LRMKTVISPRGRCLNLK 182

  Fly   187 ANAYELVKFVGYFRNDTNTSTGSSSEVSNGSN---GQPAVLPRIFQQNPNAEVDKKLVFVGTGRV 248
            :..|:.|.|:.:    :..|||.......|..   ||...       |.||....|.       .
 Worm   183 SALYKSVSFLVH----SKVSTGGHVSFMQGITIPAGQGTT-------NANASAMTKY-------T 229

  Fly   249 QNPQLIREMSIIDPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIV 313
            ::|.            ..||::|:.:.:..|:..:...|:......::|||.|:..|..|:..:.
 Worm   230 ESPM------------GAFTTRHTCDMRITFVSDKFNYILKSELKTLMGTSFYELVHPADMMIVS 282

  Fly   314 ACHEELRQTGEGKSCYYRFLTKGQQWIWLQTDYYVSYHQF-NSKPDYVVCTHKV--VSYAE---- 371
            ...:||...|..::.|||.:.......|:||:.....|.. ..|..||:|.|.|  :..||
 Worm   283 KSMKELFAKGHIRTPYYRLIAANDTLAWIQTEATTITHTTKGQKGQYVICVHYVLGIQGAEESLV 347

  Fly   372 VLKDSRKEGQKSGNSNSITNN----GSSKVIASTGTSSKSASATTTLRDFELSSQNLDSTLLGNS 432
            |..||...|.:......:.:.    |....|.       .....|.|.:.|.....:...::|..
 Worm   348 VCTDSMPAGMQVDIKKEVDDTRDYIGRQPEIV-------ECVDFTPLIEPEDPFDTVIEPVVGGE 405

  Fly   433 LASLGTETAATSPAVDSSPMW---------------SAS---AVQPS--GSCQINP------LKT 471
            ......:..|...:.|....|               ||.   ..:||  ||...:|      .:|
 Worm   406 EPVKQADMGARKNSYDDVLQWLFRDQPSSPPPARYRSADRFRTTEPSNFGSALASPDFMDSSSRT 470

  Fly   472 SRPASSYGNISSTGISPKAKRKCYFYNNRGNDSDSTSMSTDSVTSRQSMMTHVSSQSQRQRSHHR 536
            |||.:|||            |:.....:|...|.|||.|        :.:.|.::.|
 Worm   471 SRPKTSYG------------RRAQSQGSRTTGSSSTSAS--------ATLPHSANYS-------- 507

  Fly   537 EHHRENHHNQSHHHMQQQQQHQNQQQQHQQHQQLQQQL-QHTVGTPKMVPLLPIASTQIMAGNAC 600
                                            .|.:.: |..:.:|   |...|.|.|::.|:|.
 Worm   508 --------------------------------PLAEGISQCGLNSP---PSCSIKSGQVVYGDAR 537

  Fly   601 QFPQPAYPLASPQLVAPTFLEPPQYLTAIP---MQPVIAP---FPVAPVLSPLPVQSQTDMLPDT 659
            ...:...|..|.:..:.  |.|...|....   :.|||..   |...|....:.:..:.|..|
 Worm   538 SMGRSCDPSDSSRRFSA--LSPSDTLNVSSTRGINPVIGSNDVFSTMPFADSIAIAERIDSSP-- 598

  Fly   660 VVMTPTQSQLQDQLQRKHDELQKLILQQQNELRIVSEQLLLSRY--TYLQPMMSMGFAPGNMTAA 722
             .:|..:..|.|.||.:..:|.                 .|:.:  ||....|..|..|   ...
 Worm   599 -TLTSGEPILCDDLQWEEPDLS-----------------CLAPFVDTYDMMQMDEGLPP---ELQ 642

  Fly   723 AVGNLGASGQRGLNFTGSNAVQPQFNQYGFALNSEQMLNQQDQQMMMQQQQNLHTQHQHNLQQQH 787
            |:.:|.       :||.:....|                         ..:.:|.......::.|
 Worm   643 ALYDLP-------DFTPAVPQAP-------------------------AARPVHIDRSPPAKRMH 675

  Fly   788 QSHSQLQQHTQQQHQQQQQQQQQQQQQQQQQQQQQ 822
            ||..........||.|..||.:...|.||||.:||
 Worm   676 QSGPSDLDFMYTQHYQPFQQDETYWQGQQQQNEQQ 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	14/82 (17%)
		PAS	93..153	CDD:214512	19/60 (32%)
		PAS_11	265..368	CDD:464214	27/105 (26%)
hif-1	NP_001023891.2	bHLH_SF	12..66	CDD:469605	9/53 (17%)
		PAS	89..142	CDD:214512	18/56 (32%)
		PAS_11	236..338	CDD:464214	27/101 (27%)