Protein Alignment Clk and Ncoa3

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: NP_032705.2
• Gene: Ncoa3 / 17979
• MGIID: 1276535
• Length: 1403
• Species: Mus musculus
• Alignment Length: 1383
• Identity: 284/1383 - (20%)
• Similarity: 442/1383 - (31%)
• Gaps: 550/1383 - (39%)

  Fly    24 EKKRRDQFNSLVNDLSALISTS-------SRKMDKSTVLKSTIAFLKNHNEATDRSKVFEIQQDW 81
            ||.||:|.:..:.:|:.|||.:       :.|.||..:||.|:..::   :..::.|......|.
Mouse    35 EKWRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIR---QIKEQGKTISSDDDV 96

  Fly    82 KPAFLSN--------DEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTIYDL 138
            :.|.:|:        |....|:|::||||:.|.:..|:|.:.||::|..|.|..:||.|.::|.:
Mouse    97 QKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYSI 161

  Fly   139 AYEMDHEALLNIFMNPTPVI--------EPRQTDISSSNQITFYTHLRRGGMEKVDAN-----AY 190
            .:|.|.:..|...  |...:        ..||...:.:.::...||   ..:|.|:|:     .|
Mouse   162 LHEQDRKDFLKHL--PKSTVNGVSWTNENQRQKSHTFNCRMLMKTH---DILEDVNASPETRQRY 221

  Fly   191 ELVK--------------------------------------FVGYFRNDTNTSTGSSSEVSNGS 217
            |.::                                      |:  .|:|.:....:....|..|
Mouse   222 ETMQCFALSQPRAMLEEGEDLQCCMICVARRVTAPFPSSPESFI--TRHDLSGKVVNIDTNSLRS 284

  Fly   218 NGQPA-------VLPRIFQQNPNAEVDKKLVFVGT---GRVQNPQLIREMSIID----------- 261
            :.:|.       .:.|.|..|......:|..:...   |..:.|  :...|:.|
Mouse   285 SMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYVHGHAETP--VYRFSLADGTIVSAQTKSK 347

  Fly   262 ----PTSNE---FTSKHSMEWKFLFLDHR---------------APPIIG----YMPFEVLGTSG 300
                |.:|:   |.|.|       ||...               .||..|    ..|.:.:...|
Mouse   348 LFRNPVTNDRHGFISTH-------FLQREQNGYRPNPNPAGQGIRPPAAGCGVSMSPNQNVQMMG 405

  Fly   301 YDYYHFDDLDSIVACHEELRQTGE------GKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDY 359
            ...|...|..:          ||:      |.|.....||.||.   ||:.   |.:| ||
Mouse   406 SRTYGVPDPSN----------TGQMGGARYGASSSVASLTPGQS---LQSP---SSYQ-NS---- 449

  Fly   360 VVCTHKVVSYAEVLKDSRKEGQKSGNSN------SITNNGSSKVIA-----------------ST 401
                    ||. :...|...|......|      |..|.||.|:.:                 :|
Mouse   450 --------SYG-LSMSSPPHGSPGLGPNQQNIMISPRNRGSPKMASHQFSPAAGAHSPMGPSGNT 505

  Fly   402 GTSSKSASATTTLRDFELSSQNLDSTLLGNSLASLGTETAATSPAVDSSPMWSASAVQP---SGS 463
            |:.|.|:|:.:.|   :..|:.:.::|| ::|:|.|       |.:|:||..:.|  ||   ||.
Mouse   506 GSHSFSSSSLSAL---QAISEGVGTSLL-STLSSPG-------PKLDNSPNMNIS--QPSKVSGQ 557

  Fly   464 ---------CQINPLKTS--------RPA-----SSYGNISSTGISP---KAKRK------CYFY 497
                     |:.||:::|        .|:     .|.|.:|.|...|   |..:|      | ..
Mouse   558 DSKSPLGLYCEQNPVESSVCQSNSRDHPSEKESKESSGEVSETPRGPLESKGHKKLLQLLTC-SS 621

  Fly   498 NNRGNDSDSTSM-------STDSVTSRQSMMTH----VSSQSQRQRSHHREHHRENHHNQSHHHM 551
            ::||:.|.:.|.       |:.||||...:.:.    |||.|....|..:|.||..|....:.:.
Mouse   622 DDRGHSSLTNSPLDPNCKDSSVSVTSPSGVSSSTSGTVSSTSNVHGSLLQEKHRILHKLLQNGNS 686

  Fly   552 QQQ------------------------QQHQNQQQQHQQH-----------------QQLQQQL- 574
            ..:                        :|.|...::.:.:                 ::||.|.
Mouse   687 PAEVAKITAEATGKDTSSTASCGEGTTRQEQLSPKKKENNALLRYLLDRDDPSDVLAKELQPQAD 751

  Fly   575 -------QHTVGT---------PK---------------MVPLL-----------------PIAS 591
                   |.:..|         ||               :..:|                 |.|.
Mouse   752 SGDSKLSQCSCSTNPSSGQEKDPKIKTETNEEVSGDLDNLDAILGDLTSSDFYNNPTNGGHPGAK 816

  Fly   592 TQIMAGNA---CQFPQPAYPLASPQLVAPTFLEPPQYLTAIPMQPVIA--PFPVAPVL--SPLPV 649
            .|:.||.:   .:.|||...:..|...|.:...|....:..|::.|.|  ..|..|:|  :|..:
Mouse   817 QQMFAGPSSLGLRSPQPVQSVRPPYNRAVSLDSPVSVGSGPPVKNVSAFPGLPKQPILAGNPRMM 881

  Fly   650 QSQ----TDMLPD-TVVMTPTQSQLQDQLQRKHDELQKLILQQQNELRIVSEQLLLSRYTYLQPM 709
            .||    .:|.|: .|.:.||.|.....|..                         ||.:.::|:
Mouse   882 DSQENYGANMGPNRNVPVNPTSSPGDWGLAN-------------------------SRASRMEPL 921

  Fly   710 MSMGFAPGNMTAAAVGNLGASGQRGL---NFTGSNAVQPQFNQYGFALNSEQMLNQQDQQMMMQQ 771
            .|          :.:|..||.....|   ...||....|
Mouse   922 AS----------SPLGRTGADYSATLPRPAMGGSVPTLP-------------------------- 950

  Fly   772 QQNLHTQHQHNLQQQHQSHSQLQQHTQQQHQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQ 836
                                 |:.:.....:...||||||||||||||||||||||||||||.||
Mouse   951 ---------------------LRSNRLPGARPSLQQQQQQQQQQQQQQQQQQQQQQQQQQQQMLQ 994

  Fly   837 LQ--------------------------------------QQNDILLREDIDDI----------- 852
            ::                                      .||..|||..:||:
Mouse   995 MRTGEIPMGMGVNPYSPAVPSNQPGSWPEGMLSMEQGPHGSQNRPLLRNSLDDLLGPPSNAEGQS 1059

  Fly   853 DAFLNLSPLHSLGSQSTINPFNSSSN--------NNNQSYNGGSNLNNGNQ------------NN 897
            |....|..||:|.|.:..........        |..|:.....::..|.:            ..
Mouse  1060 DERALLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALESKQDVFQGQEAAVMMDQKAALYGQ 1124

  Fly   898 NNRSSNPPQNNNEDSLLSCMQMATESSPSINFHMG-ISDDGS-ETQSEDNKMMH----------T 950
            ...:..||.....:        ....|||.|..|| ||..|| ..|.     ||          .
Mouse  1125 TYPAQGPPLQGGFN--------LQGQSPSFNSMMGQISQQGSFPLQG-----MHPRAGLVRPRTN 1176

  Fly   951 SGSNLVQQQQQQQQQQQILQQHQQQSNSFFSSNP--------------FLNSQNQNQNQLPNDLE 1001
            :...|..|.||:.|.||.|.| .:|:......||              |.|:|...|.:    .|
Mouse  1177 TPKQLRMQLQQRLQGQQFLNQ-SRQALEMKMENPAGTAVMRPMMPQQAFFNAQMAAQQK----RE 1236

  Fly  1002 ILPYQMSQEQSQNLFNSP 1019
            ::.:.:.|::...:.:.|
Mouse  1237 LMSHHLQQQRMAMMMSQP 1254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	18/68 (26%)
		PAS	93..153	CDD:214512	21/59 (36%)
		PAS_11	265..368	CDD:464214	27/130 (21%)
Ncoa3	NP_032705.2	bHLH_SF	33..102	CDD:469605	18/69 (26%)
		PAS	117..172	CDD:214512	20/54 (37%)
		PAS_11	262..372	CDD:464214	21/120 (18%)
		NCOA_u2	451..564	CDD:465223	30/126 (24%)
		SRC-1	608..696	CDD:462615	21/88 (24%)
		DUF4927	714..801	CDD:465083	10/86 (12%)
		Nuc_rec_co-act	1056..1102	CDD:462608	8/45 (18%)
		Med15	1094..>1395	CDD:312941	37/179 (21%)
		DUF1518	1270..1327	CDD:462174