DRSC/TRiP Functional Genomics Resources

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Protein Alignment Clk and Ncoa3

DIOPT Version :9

Sequence 1:NP_001014576.1 Gene:Clk / 38872 FlyBaseID:FBgn0023076 Length:1027 Species:Drosophila melanogaster
Sequence 2:NP_032705.2 Gene:Ncoa3 / 17979 MGIID:1276535 Length:1403 Species:Mus musculus


Alignment Length:1383 Identity:284/1383 - (20%)
Similarity:442/1383 - (31%) Gaps:550/1383 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 EKKRRDQFNSLVNDLSALISTS-------SRKMDKSTVLKSTIAFLKNHNEATDRSKVFEIQQDW 81
            ||.||:|.:..:.:|:.|||.:       :.|.||..:||.|:..::   :..::.|......|.
Mouse    35 EKWRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIR---QIKEQGKTISSDDDV 96

  Fly    82 KPAFLSN--------DEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTIYDL 138
            :.|.:|:        |....|:|::||||:.|.:..|:|.:.||::|..|.|..:||.|.::|.:
Mouse    97 QKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYSI 161

  Fly   139 AYEMDHEALLNIFMNPTPVI--------EPRQTDISSSNQITFYTHLRRGGMEKVDAN-----AY 190
            .:|.|.:..|...  |...:        ..||...:.:.::...||   ..:|.|:|:     .|
Mouse   162 LHEQDRKDFLKHL--PKSTVNGVSWTNENQRQKSHTFNCRMLMKTH---DILEDVNASPETRQRY 221

  Fly   191 ELVK--------------------------------------FVGYFRNDTNTSTGSSSEVSNGS 217
            |.::                                      |:  .|:|.:....:....|..|
Mouse   222 ETMQCFALSQPRAMLEEGEDLQCCMICVARRVTAPFPSSPESFI--TRHDLSGKVVNIDTNSLRS 284

  Fly   218 NGQPA-------VLPRIFQQNPNAEVDKKLVFVGT---GRVQNPQLIREMSIID----------- 261
            :.:|.       .:.|.|..|......:|..:...   |..:.|  :...|:.|           
Mouse   285 SMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYVHGHAETP--VYRFSLADGTIVSAQTKSK 347

  Fly   262 ----PTSNE---FTSKHSMEWKFLFLDHR---------------APPIIG----YMPFEVLGTSG 300
                |.:|:   |.|.|       ||...               .||..|    ..|.:.:...|
Mouse   348 LFRNPVTNDRHGFISTH-------FLQREQNGYRPNPNPAGQGIRPPAAGCGVSMSPNQNVQMMG 405

  Fly   301 YDYYHFDDLDSIVACHEELRQTGE------GKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDY 359
            ...|...|..:          ||:      |.|.....||.||.   ||:.   |.:| ||    
Mouse   406 SRTYGVPDPSN----------TGQMGGARYGASSSVASLTPGQS---LQSP---SSYQ-NS---- 449

  Fly   360 VVCTHKVVSYAEVLKDSRKEGQKSGNSN------SITNNGSSKVIA-----------------ST 401
                    ||. :...|...|......|      |..|.||.|:.:                 :|
Mouse   450 --------SYG-LSMSSPPHGSPGLGPNQQNIMISPRNRGSPKMASHQFSPAAGAHSPMGPSGNT 505

  Fly   402 GTSSKSASATTTLRDFELSSQNLDSTLLGNSLASLGTETAATSPAVDSSPMWSASAVQP---SGS 463
            |:.|.|:|:.:.|   :..|:.:.::|| ::|:|.|       |.:|:||..:.|  ||   ||.
Mouse   506 GSHSFSSSSLSAL---QAISEGVGTSLL-STLSSPG-------PKLDNSPNMNIS--QPSKVSGQ 557

  Fly   464 ---------CQINPLKTS--------RPA-----SSYGNISSTGISP---KAKRK------CYFY 497
                     |:.||:::|        .|:     .|.|.:|.|...|   |..:|      | ..
Mouse   558 DSKSPLGLYCEQNPVESSVCQSNSRDHPSEKESKESSGEVSETPRGPLESKGHKKLLQLLTC-SS 621

  Fly   498 NNRGNDSDSTSM-------STDSVTSRQSMMTH----VSSQSQRQRSHHREHHRENHHNQSHHHM 551
            ::||:.|.:.|.       |:.||||...:.:.    |||.|....|..:|.||..|....:.:.
Mouse   622 DDRGHSSLTNSPLDPNCKDSSVSVTSPSGVSSSTSGTVSSTSNVHGSLLQEKHRILHKLLQNGNS 686

  Fly   552 QQQ------------------------QQHQNQQQQHQQH-----------------QQLQQQL- 574
            ..:                        :|.|...::.:.:                 ::||.|. 
Mouse   687 PAEVAKITAEATGKDTSSTASCGEGTTRQEQLSPKKKENNALLRYLLDRDDPSDVLAKELQPQAD 751

  Fly   575 -------QHTVGT---------PK---------------MVPLL-----------------PIAS 591
                   |.:..|         ||               :..:|                 |.|.
Mouse   752 SGDSKLSQCSCSTNPSSGQEKDPKIKTETNEEVSGDLDNLDAILGDLTSSDFYNNPTNGGHPGAK 816

  Fly   592 TQIMAGNA---CQFPQPAYPLASPQLVAPTFLEPPQYLTAIPMQPVIA--PFPVAPVL--SPLPV 649
            .|:.||.:   .:.|||...:..|...|.:...|....:..|::.|.|  ..|..|:|  :|..:
Mouse   817 QQMFAGPSSLGLRSPQPVQSVRPPYNRAVSLDSPVSVGSGPPVKNVSAFPGLPKQPILAGNPRMM 881

  Fly   650 QSQ----TDMLPD-TVVMTPTQSQLQDQLQRKHDELQKLILQQQNELRIVSEQLLLSRYTYLQPM 709
            .||    .:|.|: .|.:.||.|.....|..                         ||.:.::|:
Mouse   882 DSQENYGANMGPNRNVPVNPTSSPGDWGLAN-------------------------SRASRMEPL 921

  Fly   710 MSMGFAPGNMTAAAVGNLGASGQRGL---NFTGSNAVQPQFNQYGFALNSEQMLNQQDQQMMMQQ 771
            .|          :.:|..||.....|   ...||....|                          
Mouse   922 AS----------SPLGRTGADYSATLPRPAMGGSVPTLP-------------------------- 950

  Fly   772 QQNLHTQHQHNLQQQHQSHSQLQQHTQQQHQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQ 836
                                 |:.:.....:...||||||||||||||||||||||||||||.||
Mouse   951 ---------------------LRSNRLPGARPSLQQQQQQQQQQQQQQQQQQQQQQQQQQQQMLQ 994

  Fly   837 LQ--------------------------------------QQNDILLREDIDDI----------- 852
            ::                                      .||..|||..:||:           
Mouse   995 MRTGEIPMGMGVNPYSPAVPSNQPGSWPEGMLSMEQGPHGSQNRPLLRNSLDDLLGPPSNAEGQS 1059

  Fly   853 DAFLNLSPLHSLGSQSTINPFNSSSN--------NNNQSYNGGSNLNNGNQ------------NN 897
            |....|..||:|.|.:..........        |..|:.....::..|.:            ..
Mouse  1060 DERALLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALESKQDVFQGQEAAVMMDQKAALYGQ 1124

  Fly   898 NNRSSNPPQNNNEDSLLSCMQMATESSPSINFHMG-ISDDGS-ETQSEDNKMMH----------T 950
            ...:..||.....:        ....|||.|..|| ||..|| ..|.     ||          .
Mouse  1125 TYPAQGPPLQGGFN--------LQGQSPSFNSMMGQISQQGSFPLQG-----MHPRAGLVRPRTN 1176

  Fly   951 SGSNLVQQQQQQQQQQQILQQHQQQSNSFFSSNP--------------FLNSQNQNQNQLPNDLE 1001
            :...|..|.||:.|.||.|.| .:|:......||              |.|:|...|.:    .|
Mouse  1177 TPKQLRMQLQQRLQGQQFLNQ-SRQALEMKMENPAGTAVMRPMMPQQAFFNAQMAAQQK----RE 1236

  Fly  1002 ILPYQMSQEQSQNLFNSP 1019
            ::.:.:.|::...:.:.|
Mouse  1237 LMSHHLQQQRMAMMMSQP 1254

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClkNP_001014576.1 HLH 16..68 CDD:238036 15/50 (30%)
PAS 93..153 CDD:214512 21/59 (36%)
PAS 264..366 CDD:238075 27/129 (21%)
PAS_11 265..368 CDD:291273 27/130 (21%)
Ncoa3NP_032705.2 bHLH_SF 33..102 CDD:381792 18/69 (26%)
PAS 117..172 CDD:214512 20/54 (37%)
PAS_11 262..372 CDD:373151 21/120 (18%)
NCOA_u2 451..564 CDD:374708 30/126 (24%)
SRC-1 608..696 CDD:370145 21/88 (24%)
DUF4927 714..801 CDD:374467 10/86 (12%)
Nuc_rec_co-act 1056..1103 CDD:312376 8/46 (17%)
Med15 1094..>1398 CDD:312941 37/179 (21%)
DUF1518 1270..1326 CDD:369380
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3561
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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