Protein Alignment Clk and Ncoa2

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_017174718.1
• Gene: Ncoa2 / 17978
• MGIID: 1276533
• Length: 1517
• Species: Mus musculus
• Alignment Length: 1359
• Identity: 260/1359 - (19%)
• Similarity: 427/1359 - (31%)
• Gaps: 422/1359 - (31%)

  Fly    23 SEKKRRDQFNSLVNDLSALISTS-------SRKMDKSTVLKSTIAFLK--NHNEATDRSKVFEIQ 78
            :||:.|:|.|..:.:|:.||..:       :.|.||..:||.|:..::  ...|....:.:.|:|
Mouse    34 TEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQ 98

  Fly    79 Q----DWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTIYDLA 139
            :    ......:..|....:|||:||||..|.:..||:.:.||::|..|.|..::|.|.::|.:.
Mouse    99 KSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGSVVFVSENVTQYLRYNQEELMNKSVYSIL 163

  Fly   140 YEMDH-EALLNIFMNPTPVIE--------PRQTDISSSNQITFYTHLRRGGMEKVDANAYELVKF 195
            :..|| |.:.|:.  |..::.        ||:    ||:  ||              |...|||.
Mouse   164 HVGDHTEFVKNLL--PKSMVNGGSWSGEPPRR----SSH--TF--------------NCRMLVKP 206

  Fly   196 VGYFRNDTNTSTGSSSEVSNG-------SNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRV---QN 250
            :    .|:......|.|....       :..||..:     :....::...|:.|.. ||   :.
Mouse   207 L----PDSEEEGHDSQEAHQKYEAMQCFAVSQPKSI-----KEEGEDLQSCLICVAR-RVPMKER 261

  Fly   251 PQLIREMSIIDPTSNEFTSKHSMEWKFLFLD---HRAPPIIGYMPFEVLGTSGYDYYHF----DD 308
            |.|        |:|..||::..::.|...||   .||....|:   |.|.......:|.    :.
Mouse   262 PTL--------PSSESFTTRQDLQGKITSLDTSTMRAAMKPGW---EDLVRRCIQKFHTQHEGES 315

  Fly   309 LDSIVACHEELRQTGEGKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEV- 372
            |......|.|:.:.|...|..|||.......:..||...:...|..::|..|:..|.:.....|
Mouse   316 LSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQNVC 380

  Fly   373 LKDSRKEGQKSGNS-NSIT------------NNGSSKVIAST----------------------- 401
            :.:....||..|.. |.|:            |.|....:.|.
Mouse   381 VMNPDLTGQAMGKPLNPISSSSPAHQALCSGNPGQDMTLGSNINFPMNGPKEQMGMPMGRFGGSG 445

  Fly   402 GTSSKSASATTTLRD----FELSSQNLDSTLLG-NSLASLGTETAATSPAVDSSPMWSASAVQPS 461
            |.:..|....||.:.    .:::|.:..|..:. ...:|:.:.....||.|..||....|...|:
Mouse   446 GMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPGQASSVLSPRQRMSPGVAGSPRIPPSQFSPA 510

  Fly   462 GS-------C------------QINPLKT-------------SRPASSYGNISSTGIS----PKA 490
            ||       |            .:|.|:.             :.|....||:.::.::    |.:
Mouse   511 GSLHSPVGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLS 575

  Fly   491 K------RKCY-FYNNRGNDSDSTSMSTD-SVTSRQSMMTHVSSQSQRQRSHHREHHRENHHNQS 547
            |      :.|: .|   |..|:.|:...: |....:....:.||..|.......|.|...|.::.
Mouse   576 KMGSLDSKDCFGLY---GEPSEGTTGQAEASCHPEEQKGPNDSSMPQAASGDRAEGHSRLHDSKG 637

  Fly   548 HHHMQQQQQHQNQQQQ------------------------------HQQHQQLQQQLQHTVGTPK 582
            ...:.|....::.|.:                              .::|:.|.:.||.:.....
Mouse   638 QTKLLQLLTTKSDQMEPSPLPSSLSDTNKDSTGSLPGPGSTHGTSLKEKHKILHRLLQDSSSPVD 702

  Fly   583 MVPL--------LPIASTQIMAGNACQFPQ-PAYP-------------------LASPQLVAPTF 619
            :..|        |...|:....|:.....| ||.|                   :..|: :.|..
Mouse   703 LAKLTAEATGKELSQESSSTAPGSEVTVKQEPASPKKKENALLRYLLDKDDTKDIGLPE-ITPKL 766

  Fly   620 ------LEPPQYLTAIPMQPVIAPFPVAP-------------VLSPLPVQSQTDMLPDTVVMTPT 665
                  .:|......|.|:.|.......|             :|..|.......:.|||....||
Mouse   767 ERLDSKTDPASNTKLIAMKTVKEEVSFEPSDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPT 831

  Fly   666 -----QSQLQDQLQRKHDE-------LQKLILQQQNEL----------RIVSEQLLLSRYTYLQP 708
                 |:.:.|.:|...|.       .||..|:.....          |::..|.|....|...|
Mouse   832 GSVDKQAIINDLMQLTADSSPVPPAGAQKAALRMSQSTFNNPRPGQLGRLLPNQNLPLDITLQSP 896

  Fly   709 MMSMGFAP----------------GNMTAAAVGNLGASGQRGLNFT---GSNAVQPQFNQYGFAL 754
            ..:..|.|                ||.     |.||:.|..|.|.|   ||:..:|......:|.
Mouse   897 TGAGPFPPIRNSSPYSVIPQPGMMGNQ-----GMLGSQGNLGNNSTGMIGSSTSRPSMPSGEWAP 956

  Fly   755 NSEQM----------LNQQDQQMMMQ-------QQQNLHTQHQHNLQQQHQSHSQLQQHTQQQHQ 802
            .|..:          :|:..|..|::       .:.|.....:..||.|..:....:........
Mouse   957 QSPAVRVTCAATTGAMNRPVQGGMIRNPTASIPMRANSQPGQRQMLQSQVMNIGPSELEMNMGGP 1021

  Fly   803 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQLQQQ------NDIL----------------- 844
            |..|||....|.....:......|.....|..|.|.:|      :|:|
Mouse  1022 QYNQQQAPPNQTAPWPESILPIDQASFASQNSLSLYRQPFGSSPDDLLCPHPAAESPSDEGALLD 1086

  Fly   845 -----LR--EDIDDIDAFLNLSPLHSLGSQSTINPFNSSSN----------------NNNQSYNG 886
                 ||  :.:::||..|.:..|.|.........|:|..:                :..|...|
Mouse  1087 QLYLALRNFDGLEEIDRALGIPELVSQSQAVDAEQFSSQESSIMLEQKPPVFPQQYASQAQMAQG 1151

  Fly   887 GSN-LNNGN---------------------------QNNNNRSSNPPQN-----NNEDSLLSCMQ 918
            |.| :.:.|                           ||..|:.....|:     .|...|::  |
Mouse  1152 GYNPMQDPNFHTMGQRPNYTTLRMQPRPGLRPTGIVQNQPNQLRLQLQHRLQAQQNRQPLMN--Q 1214

  Fly   919 MATESSPSINFHMGISDDGSETQSEDNKMM------HTSGSNLVQQQQQQQQQQQILQQHQQQSN 977
            :::.|:.::....|:     .||:..|..|      .....:|.|:|.|||.||:.|....|..|
Mouse  1215 ISSVSNVNLTLRPGV-----PTQAPINAQMLAQRQREILNQHLRQRQMQQQVQQRTLMMRGQGLN 1274

  Fly   978 SFFS-----------SNPFLNSQNQNQNQLPNDLEILPYQMSQEQSQNLFNSPHTAPGS 1025
            ...|           |||.:...|..|...|.:     |.:||:.......:  |.|.|
Mouse  1275 VTPSMVAPAGLPAAMSNPRIPQANAQQFPFPPN-----YGISQQPDPGFTGA--TTPQS 1326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	17/75 (23%)
		PAS	93..153	CDD:214512	22/60 (37%)
		PAS_11	265..368	CDD:464214	25/109 (23%)
Ncoa2	XP_017174718.1	bHLH-PAS_NCoA2_SRC2	28..91	CDD:381520	15/56 (27%)
		PAS	118..175	CDD:214512	21/56 (38%)
		PAS_11	268..378	CDD:464214	25/112 (22%)
		NCOA_u2	463..587	CDD:465223	21/123 (17%)
		SRC-1	636..709	CDD:462615	7/72 (10%)
		DUF4927	731..816	CDD:465083	13/85 (15%)
		Nuc_rec_co-act	1076..1120	CDD:462608	7/43 (16%)
		DUF1518	1284..1341	CDD:462174	12/50 (24%)