DRSC/TRiP Functional Genomics Resources

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Protein Alignment Clk and Hif1a

DIOPT Version :10

Sequence 1:NP_001014576.1 Gene:Clk / 38872 FlyBaseID:FBgn0023076 Length:1027 Species:Drosophila melanogaster
Sequence 2:NP_001300848.1 Gene:Hif1a / 15251 MGIID:106918 Length:837 Species:Mus musculus


Alignment Length:850 Identity:172/850 - (20%)
Similarity:312/850 - (36%) Gaps:218/850 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 KSRNLSEKKRRDQ---FNSLVNDLSALISTSSRKMDKSTVLKSTIAFLKNHN-------EATDRS 72
            |||:.:..:|..:   |..|.:.|....:.||. :||::|::.||::|:...       ::.|..
Mouse    22 KSRDAARSRRSKESEVFYELAHQLPLPHNVSSH-LDKASVMRLTISYLRVRKLLDAGGLDSEDEM 85

  Fly    73 KVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTIYD 137
            |.   |.|.            ..|::||||:||.:..|.:.|.|:::...:|....:|...:::|
Mouse    86 KA---QMDC------------FYLKALDGFVMVLTDDGDMVYISDNVNKYMGLTQFELTGHSVFD 135

  Fly   138 LAYEMDHEALLNIFMNPT-PVIEPRQTDISSSNQITFYTHLR-----RGGMEKVDANAYELVKFV 196
            ..:..|||.:..:..:.. ||.:.::.    :.|.:|:..::     ||....:.:..::::...
Mouse   136 FTHPCDHEEMREMLTHRNGPVRKGKEL----NTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCT 196

  Fly   197 GYFR-NDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSII 260
            |:.. .|||     |::...|....|...               ||.: ...:.:|..|.    |
Mouse   197 GHIHVYDTN-----SNQPQCGYKKPPMTC---------------LVLI-CEPIPHPSNIE----I 236

  Fly   261 DPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGEG 325
            ...|..|.|:||::.||.:.|.|...::||.|.|:||.|.|:|||..|.|.:...|.::...|:.
Mouse   237 PLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV 301

  Fly   326 KSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKEGQKSGNSNSIT 390
            .:..||.|.|...::|::|...|.|:..||:|..:||.:.||| ..:..|.....|:   :.|:.
Mouse   302 TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVS-GIIQHDLIFSLQQ---TESVL 362

  Fly   391 NNGSSKVIASTGTSSKSASATTTLRDFELSSQNLDSTLL----GNSLASL---GTETAATSPAVD 448
            ....|..:..|...:|..|..|:....:|..:....|||    |:::.||   ..:|......::
Mouse   363 KPVESSDMKMTQLFTKVESEDTSCLFDKLKKEPDALTLLAPAAGDTIISLDFGSDDTETEDQQLE 427

  Fly   449 SSPMWSASAVQPSGSCQIN------PLKTSRPASSYGNISSTGISPKAKRKCYFYNNRGNDSDST 507
            ..|::: ..:.||.:.::|      ||.:|.             :||..|.              
Mouse   428 DVPLYN-DVMFPSSNEKLNINLAMSPLPSSE-------------TPKPLRS-------------- 464

  Fly   508 SMSTDSVTSRQSMMTHVSSQSQRQRSHHREHHRENHHNQSHHHMQQQQQHQNQQQQHQQHQQLQQ 572
              |.|...:::..:...||....              ..|....|.|.|..:......:....::
Mouse   465 --SADPALNQEVALKLESSPESL--------------GLSFTMPQIQDQPASPSDGSTRQSSPER 513

  Fly   573 QLQHTVGTPKMVPLLPIASTQIMAGNACQFPQPAYP-------------LASPQLVAPTFLEPPQ 624
            .||..|.||                   .|.||..|             :...:||...|.|..:
Mouse   514 LLQENVNTP-------------------NFSQPNSPSEYCFDVDSDMVNVFKLELVEKLFAEDTE 559

  Fly   625 YLTAIPMQ------PVIAPF----------------------PVAPVLSPLPVQSQTDMLPDTVV 661
            .......|      .::||:                      |..|.:|.:....||.:...|:.
Mouse   560 AKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESNSPSPPSMSTVTGFQQTQLQKPTIT 624

  Fly   662 MTPTQSQLQDQLQ---RKHDELQKLILQQQNELRIVSEQLLLSRYTYLQPMMSMGFAPGNMTAAA 723
            .|.|.:...|:.:   :.:.|..|:::...:..::..|                     ..||.|
Mouse   625 ATATTTATTDESKTETKDNKEDIKILIASPSSTQVPQE---------------------TTTAKA 668

  Fly   724 VGNLG-----ASGQRGLNFTGSNAVQPQFNQYGFALNSEQMLNQQDQQMMMQQQQNLHTQHQHNL 783
            ....|     ||..|    .|...::.....:..:||....|||::  .:.:::.|..|....|.
Mouse   669 SAYSGTHSRTASPDR----AGKRVIEQTDKAHPRSLNLSATLNQRN--TVPEEELNPKTIASQNA 727

  Fly   784 QQQHQ 788
            |::.:
Mouse   728 QRKRK 732

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClkNP_001014576.1 bHLH-PAS_dCLOCK 11..86 CDD:381578 19/77 (25%)
PAS 93..153 CDD:214512 16/59 (27%)
PAS_11 265..368 CDD:464214 37/102 (36%)
Hif1aNP_001300848.1 bHLH-PAS_HIF1a_PASD8 14..84 CDD:381570 15/62 (24%)
DNA-binding. /evidence=ECO:0000269|PubMed:26245371 22..31 3/8 (38%)
PAS 94..149 CDD:214512 16/54 (30%)
Required for heterodimer formation with ARNT. /evidence=ECO:0000269|PubMed:26245371 171..192 2/20 (10%)
PAS_3 255..340 CDD:430001 30/84 (36%)
N-terminal VHL recognition site 381..418 9/36 (25%)
ODD 402..614 41/274 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 493..512 3/18 (17%)
NTAD 545..589 7/43 (16%)
HIF-1 565..594 CDD:463274 3/28 (11%)
C-terminal VHL recognition site 570..586 2/15 (13%)
ID 590..796 29/169 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 594..685 19/115 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 708..735 5/26 (19%)
Nuclear localization signal. /evidence=ECO:0000255 729..732 0/2 (0%)
CTAD 797..837
HIF-1a_CTAD 800..836 CDD:430212
Blue background indicates that the domain is not in the aligned region.

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