DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Clk and Clock

DIOPT Version :9

Sequence 1:NP_001014576.1 Gene:Clk / 38872 FlyBaseID:FBgn0023076 Length:1027 Species:Drosophila melanogaster
Sequence 2:NP_001276755.1 Gene:Clock / 12753 MGIID:99698 Length:855 Species:Mus musculus


Alignment Length:1017 Identity:328/1017 - (32%)
Similarity:457/1017 - (44%) Gaps:242/1017 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 ESDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSSRKMDKSTVLKSTIAFLKNHNEA 68
            |.||||..|    |.|||.||||||||||.|:.:|.:::..::|||||||||:.:|.||:.|.|.
Mouse    27 EEDDKDKAK----RVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHKET 87

  Fly    69 TDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNM 133
            |.:|...||:|||||.||||:|:|.||||:||||.:...:.|||.|.|||:||.|.:||.||.:.
Mouse    88 TAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQ 152

  Fly   134 TIYDLAYEMDHEALLNIFMNPTPVIEPRQTD---ISSSNQITFYTHLRRGGMEKVDANAYELVKF 195
            :|::...|.:|..:..|.  .|.::|.....   :.|.||:.|..|:.||.::..:.:.||.|:|
Mouse   153 SIFNFIPEGEHSEVYKIL--STHLLESDSLTPEYLKSKNQLEFCCHMLRGTIDPKEPSTYEYVRF 215

  Fly   196 VGYFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSII 260
            :|.|::.|:.||.:    .||..|       ..|:......:.::.||.|.|:..||.|:||..:
Mouse   216 IGNFKSLTSVSTST----HNGFEG-------TIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTV 269

  Fly   261 DPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGEG 325
            :..:.||||:||:|||||||||||||||||:||||||||||||||.|||:::..|||.|.|.|:|
Mouse   270 EEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKG 334

  Fly   326 KSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKE----------- 379
            |||||||||||||||||||.||::|||:||:|:::||||.|||||||..:.|:|           
Mouse   335 KSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAERRRELGIEESLPETA 399

  Fly   380 ---GQKSGNSNSITNNGSSKVIASTGTSSKSASATTTLRDFELSSQNLDSTLLGNSLASLGTETA 441
               .|.||:.|.| |..|.|........|.:.||::.      ||:.             .:.||
Mouse   400 ADKSQDSGSDNRI-NTVSLKEALERFDHSPTPSASSR------SSRK-------------SSHTA 444

  Fly   442 ATSPAVDSSPMWSASAVQPSGSCQINPLKTSRPAS-SYGNISSTGISPKAKRKCYFYNNRGNDSD 505
            .:.|:...:.:.:.::..|......:...|.|.:| |..:|:|..:.|...:..  .:...|...
Mouse   445 VSDPSSTPTKIPTDTSTPPRQHLPAHEKMTQRRSSFSSQSINSQSVGPSLTQPA--MSQAANLPI 507

  Fly   506 STSMSTDSVTSRQSMMTHVSSQ-SQRQRSHHREHHRENHHNQSHHHMQQQQQHQNQQQQHQQH-Q 568
            ...||....:::...|.|:..| .||.|......||           ||::..:.|:|....| |
Mouse   508 PQGMSQFQFSAQLGAMQHLKDQLEQRTRMIEANIHR-----------QQEELRKIQEQLQMVHGQ 561

  Fly   569 QLQQQLQHTVGTPKMVPLLPIASTQIMAGNACQFPQPAYPLASPQLVAPTFLEPPQYLTAIPMQP 633
            .||..||.:      .|.|...|.|:.:||:                      ..|.||      
Mouse   562 GLQMFLQQS------NPGLNFGSVQLSSGNS----------------------NIQQLT------ 592

  Fly   634 VIAPFPVAPVLSPLPVQSQTDMLPDTVVMTPTQSQLQDQLQRKHDELQKLILQQQNELRIVSEQL 698
                          ||..|..::|...|.:...|..|..:|::  .||....||       |:|.
Mouse   593 --------------PVNMQGQVVPANQVQSGHISTGQHMIQQQ--TLQSTSTQQ-------SQQS 634

  Fly   699 LLSRYTYLQPMMSMGFAPGNMTAAAVGNLGASGQRGLNFTGSNAVQPQFNQYGFALNSEQMLN-- 761
            ::|.::....:.|.  .|..:||.....:..|.....:.....:..||        ||.|...  
Mouse   635 VMSGHSQQTSLPSQ--TPSTLTAPLYNTMVISQPAAGSMVQIPSSMPQ--------NSTQSATVT 689

  Fly   762 --QQDQQMMMQQQQNLHTQ-----------HQHNLQQQHQSHSQLQQHTQQQHQQQQQQQQQQQQ 813
              .||:|:...|.|.|.|:           ...:.....|..:.......||.|.|.....||||
Mouse   690 TFTQDRQIRFSQGQQLVTKLVTAPVACGAVMVPSTMLMGQVVTAYPTFATQQQQAQTLSVTQQQQ 754

  Fly   814 QQQQQQQQQQQQQQQQQQQQQLQLQQQNDILLREDIDDIDAFLNLSPLHSLGSQSTINPFNSSSN 878
            |||||..||||||||..|:|||...||                               |..:...
Mouse   755 QQQQQPPQQQQQQQQSSQEQQLPSVQQ-------------------------------PAQAQLG 788

  Fly   879 NNNQSYNGGSNLNNGNQNNN---------NRSSNPPQNNNEDSLLSCMQMATESSPSINFHMGIS 934
            ...|.:...|.|.:||.:..         .:|:.||.::                          
Mouse   789 QPPQQFLQTSRLLHGNPSTQLILSAAFPLQQSTFPPSHH-------------------------- 827

  Fly   935 DDGSETQSEDNKMMHTSGSNLVQQQQQQQQQQQILQQHQQQS 976
                                    ||.|.||||.|.:|:..|
Mouse   828 ------------------------QQHQPQQQQQLPRHRTDS 845

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClkNP_001014576.1 HLH 16..68 CDD:238036 29/51 (57%)
PAS 93..153 CDD:214512 26/59 (44%)
PAS 264..366 CDD:238075 78/101 (77%)
PAS_11 265..368 CDD:291273 79/102 (77%)
ClockNP_001276755.1 bHLH-PAS_CLOCK 29..89 CDD:381577 35/63 (56%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:19414601 32..47 10/18 (56%)
PAS 109..>177 CDD:366402 29/69 (42%)
PAS_11 274..377 CDD:373151 79/102 (77%)
Interaction with NR3C1. /evidence=ECO:0000269|PubMed:19141540 371..854 145/656 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..411 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 420..497 16/95 (17%)
Interaction with SIRT1. /evidence=ECO:0000269|PubMed:18662547 450..570 29/132 (22%)
Implicated in the circadian rhythmicity 514..564 14/60 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 613..650 10/47 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 752..791 23/69 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 814..855 13/82 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 198 1.000 Domainoid score I3085
eggNOG 1 0.900 - - E1_KOG3561
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 439 1.000 Inparanoid score I1659
Isobase 1 0.950 - 0 Normalized mean entropy S6186
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002532
OrthoInspector 1 1.000 - - otm43757
orthoMCL 1 0.900 - - OOG6_105251
Panther 1 1.100 - - O PTHR46055
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4514
SonicParanoid 1 1.000 - - X1900
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.800

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