DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Clk and Arnt

DIOPT Version :9

Sequence 1:	NP_001014576.1	Gene:	Clk / 38872	FlyBaseID:	FBgn0023076	Length:	1027	Species:	Drosophila melanogaster
Sequence 2:	NP_001032826.1	Gene:	Arnt / 11863	MGIID:	88071	Length:	791	Species:	Mus musculus

Alignment Length:	742	Identity:	168/742 - (22%)
Similarity:	284/742 - (38%)	Gaps:	223/742 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DDESDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSS---RKMDKSTVLKSTIAFLK 63
            |||....|  |..|.|::.:..|::||::..:.:.:||.::.|.|   ||.||.|:|:..::.:|
Mouse    78 DDEQSSAD--KERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK 140

  Fly    64 N----HNEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFS-SMGSIFYASESITSQL 123
            :    .|.:||.|        :||:||::.|..||:||:.|||:.:.| ..|.:.|.|:|:|..|
Mouse   141 SLRGTGNTSTDGS--------YKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVL 197

  Fly   124 GYLPQDLYNMTIYDLAYEMDHEALLNIFMNPTPVIEPRQTDISS----------------SNQIT 172
            .....:.:..|:||..:..|.:.|..........:..|..|:.:                .::.:
Mouse   198 NQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRVLDLKTGTVKKEGQQSSMRMCMGSRRS 262

  Fly   173 FYTHLRRG--GMEKVDANAYELVKFVGYFRNDTNTSTGSSSEVSNGSNGQP-------------- 221
            |...:|.|  .::.|..|.      :.:.||......||..|      |:|
Mouse   263 FICRMRCGTSSVDPVSMNR------LSFLRNRCRNGLGSVKE------GEPHFVVVHCTGYIKAW 315

  Fly   222 ----AVLPRIFQQNPNAEVDKKLVFVGTGRVQ---NPQLIREMSIIDPTSNEFTSKHSMEWKFLF 279
                ..||   ..:|.|....|...|..||:|   :|......:|..||  ||.|:|::|..|.|
Mouse   316 PPAGVSLP---DDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNICQPT--EFISRHNIEGIFTF 375

  Fly   280 LDHRAPPIIGYMPFEVLGTSGYDYYHFDD----LDSIVACHEELRQTGEGKSCYYRFLTKGQQWI 340
            :|||....:||.|.|:||.:..::.|.:|    .||.   .:.::..|:..|..:||.:|.::|:
Mouse   376 VDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSF---QQVVKLKGQVLSVMFRFRSKTREWL 437

  Fly   341 WLQTDYYVSYHQFNSKPDYVVCTHKVV-------------------------------------- 367
            |::|..:...:.::.:.:|::||:..|
Mouse   438 WMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIPRSQLGPTANLSLEMGTGQLPSR 502

  Fly   368 ----SYAEVLKDSRKEGQKSGNSNSITNNGSSKVIASTGT------------------------- 403
                .:.|:.....::|..|.|.:.:    |.:.:||.|:
Mouse   503 QQQQQHTELDMVPGRDGLASYNHSQV----SVQPVASAGSEHSKPLEKSEGLFAQDRDPRFPEIY 563

  Fly   404 ------SSKSASATTTLRDFELSSQNLD-------------------------STLLGNSLASLG 437
                  .||..|::|.....:|.||...                         |:..|..||.:.
Mouse   564 PSITADQSKGISSSTVPATQQLFSQGSSFPPNPRPAENFRNSGLTPPVTIVQPSSSAGQILAQIS 628

  Fly   438 TETAATSPAVDSSPMWSASAVQPSGSCQ----------------INPLKTSRPASSYGNISSTGI 486
            ..   ::||..|:|.|::|: :|..:.|                :|..:||   ||:..:|..|
Mouse   629 RH---SNPAQGSAPTWTSSS-RPGFAAQQVPTQATAKTRSSQFGVNNFQTS---SSFSAMSLPG- 685

  Fly   487 SPKAKRKCYFY---NNRG-NDSDSTSMSTDSVTSRQSMMTHVSSQSQRQRSHHREHHRENHHNQS 547
            :|.|......|   .||| |....|..:|....:|.:....|..|.|.|:.|||.       :.|
Mouse   686 APTASSGTAAYPALPNRGSNFPPETGQTTGQFQARTAEGVGVWPQWQGQQPHHRS-------SSS 743

  Fly   548 HHHMQQQQQHQNQQQQHQQHQQLQQQL 574
            ..|:|     |.|.|...|.:..|:.|
Mouse   744 EQHVQ-----QTQAQAPSQPEVFQEML 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	16/58 (28%)
		PAS	93..153	CDD:214512	19/60 (32%)
		PAS	264..366	CDD:238075	31/105 (30%)
		PAS_11	265..368	CDD:291273	32/148 (22%)
Arnt	NP_001032826.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..97		7/20 (35%)
		DNA-binding. /evidence=ECO:0000269\|PubMed:26245371, ECO:0000269\|PubMed:28602820	88..128		11/39 (28%)
		HLH	91..143	CDD:278439	15/51 (29%)
		Required for heterodimer formation with EPAS1. /evidence=ECO:0000269\|PubMed:26245371	112..264		41/159 (26%)
		Required for heterodimer formation with HIF1A. /evidence=ECO:0000269\|PubMed:26245371	112..168		21/63 (33%)
		PAS	163..269	CDD:279347	23/105 (22%)
		PAS	166..230	CDD:214512	19/63 (30%)
		Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000269\|PubMed:24001774	167..171		2/3 (67%)
		PAS_11	362..462	CDD:291273	31/102 (30%)
		PAS	362..458	CDD:238075	29/98 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..508		0/42 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..554		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..667		8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	682..715		10/33 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	730..791		15/48 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810