Protein Alignment Clk and NCOA2

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_016868450.1
• Gene: NCOA2 / 10499
• HGNCID: 7669
• Length: 1533
• Species: Homo sapiens
• Alignment Length: 1566
• Identity: 282/1566 - (18%)
• Similarity: 456/1566 - (29%)
• Gaps: 640/1566 - (40%)

  Fly    20 RNLSEKKRRDQFNSLVNDLSALISTS-------SRKMDKSTVLKSTIAFLK--NHNEATDRSKVF 75
            || :||:.|:|.|..:.:|:.||..:       :.|.||..:||.|:..::  ...|....:.:.
Human    32 RN-TEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANID 95

  Fly    76 EIQQ----DWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTIY 136
            |:|:    ......:..|....:|||:||||..|.:..|::.:.||::|..|.|..::|.|.::|
Human    96 EVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVY 160

  Fly   137 DLAYEMDH-EALLNIFMNPTPVIE--------PRQTDISSSNQITFYTHLRRGGMEKVDANAYEL 192
            .:.:..|| |.:.|:.  |..::.        ||:      |..||              |...|
Human   161 SILHVGDHTEFVKNLL--PKSIVNGGSWSGEPPRR------NSHTF--------------NCRML 203

  Fly   193 VKFVGYFRNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREM 257
            ||           ....|.|                :.:.|.|..:|...:....|..|:.|:|.
Human   204 VK-----------PLPDSEE----------------EGHDNQEAHQKYETMQCFAVSQPKSIKEE 241

  Fly   258 S-------------------IIDPTSNEFTSKHSMEWKFLFLD---HRAPPIIGYMPFEVLGTSG 300
            .                   .:.|:|..||::..::.|...||   .||....|:   |.|....
Human   242 GEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGW---EDLVRRC 303

  Fly   301 YDYYHFDDLDSIVAC-----HEELRQTGEGKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYV 360
            ...:|.......|:.     ||.||| |...|..|||.......:..||...:...|..::|..|
Human   304 IQKFHAQHEGESVSYAKRHHHEVLRQ-GLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLV 367

  Fly   361 VCTHKVVSYAEV-LKDSRKEGQKSGNS-NSITNNGSSKVIASTGTSSKSASATTTLRDFELSS-- 421
            :..|.:.....| :.:....||..|.. |.|::|..:.....:|...:..:.::.: :|.::.
Human   368 ISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLSSNI-NFPINGPK 431

  Fly   422 ---------------------------QNLDSTLLGNSLA------------SLGTETAATSPAV 447
                                       |..:..|..||.:            |:.:.....||.|
Human   432 EQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPGQPTSMLSPRHRMSPGV 496

  Fly   448 DSSPMWSASAVQPSGS-------C----------------------------------------- 464
            ..||....|...|:||       |
Human   497 AGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGN 561

  Fly   465 -QINPLKTSRPASS-------------YGNISSTGISPKAKRKCY-------------------- 495
             |.:|:..:.|..|             ||. .|.|.:.:|:..|:
Human   562 LQNSPVNMNPPPLSKMGSLDSKDCFGLYGE-PSEGTTGQAESSCHPGEQKETNDPNLPPAVSSER 625

  Fly   496 ------FYNNRGND----------------------SDSTSMSTDSVTSRQSMMTHVSSQSQRQR 532
                  .::::|..                      ||:...||.|:....|  ||.:|..::.:
Human   626 ADGQSRLHDSKGQTKLLQLLTTKSDQMEPSPLASSLSDTNKDSTGSLPGSGS--THGTSLKEKHK 688

  Fly   533 SHHR---------------------EHHRENHHNQ--SHHHMQQQQQHQNQQQQHQQHQQLQQQL 574
            ..||                     :..:|:....  |...::|:.....:::.......|.:..
Human   689 ILHRLLQDSSSPVDLAKLTAEATGKDLSQESSSTAPGSEVTIKQEPVSPKKKENALLRYLLDKDD 753

  Fly   575 QHTVGTPKMVPLL--------PIASTQIMAGNA-----------------------------CQF 602
            ...:|.|::.|.|        |.::|:::|...                             .|.
Human   754 TKDIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSELDNLEEILDDLQNSQL 818

  Fly   603 PQ------PAYPLAS----------PQLVA-------------------PTFLEP-PQYL-TAIP 630
            ||      |..|..|          .||.|                   .||..| |..| ..:|
Human   819 PQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQLGRLLP 883

  Fly   631 MQPV-----------IAPFPVAPVLSPLPV--------------------QSQTDMLPDT----- 659
            .|.:           ..|||.....||..|                    .|.|.|:.::
Human   884 NQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPT 948

  Fly   660 --------------VVMTPTQSQLQDQLQ-------------------RKHDELQKLIL------ 685
                          |....|.|.:...:|                   .:...||..::
Human   949 MPSGEWAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSE 1013

  Fly   686 -----------QQQ---NELRIVSEQLL-LSRYTYL-QPMMSMGFAPGNMTAAAVGNLGASGQRG 734
                       |||   |:.....|.:| :.:.::. |.....|.:|.::..........|.:..
Human  1014 LEMNMGGPQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGA 1078

  Fly   735 L---------NFTGSNAVQ-----PQFNQYGFALNSEQMLNQQDQQMMMQQ------QQ------ 773
            |         ||.|...:.     |:......|::.|| .:.||..:|::|      ||
Human  1079 LLDQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQ-FSSQDSNIMLEQKAPVFPQQYASQAQ 1142

  Fly   774 ------------NLHTQHQH------NLQ-------------QQHQSHSQLQQHTQQQHQQQ--- 804
                        |.||..|.      .:|             |.:|...|||...|.|..:|
Human  1143 MAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRLQLQHRLQAQQNRQPLM 1207

  Fly   805 -------------------------QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQLQQQNDIL 844
                                     |...|:|::...|..:|:|..||||.||:.|.::.|.
Human  1208 NQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQG--- 1269

  Fly   845 LREDIDDIDAFLNLSP--LHSLGSQSTIN--------------------------PFNS------ 875
                       ||::|  :...|..:|::                          ||.|
Human  1270 -----------LNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGTGLRSPPPFTSPFSPVS 1323

  Fly   876 ---SSNNNNQSYNGGSNLNNGNQ---NNNNRSSNPPQNNN-EDSLLSCMQMATESSPSINFHMGI 933
               .|...:.|...||.:|..||   .|......|.::.. :.|....:.......|...| .|.
Human  1324 PSVGSQLLSHSSLHGSQMNLANQGMIGNLGGQLGPVRSPQVQHSTFQALSSGISQQPDPGF-TGA 1387

  Fly   934 SDDGSETQSEDNKMMHTSGSNLVQQQQQQQQQQ-----------------QILQQH-----QQQS 976
            :...|...|.  :|.||. |.::||.|.....|                 ...||.     ||.:
Human  1388 TTPQSPLMSP--RMAHTQ-SPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQSPPHFGQQAN 1449

  Fly   977 NSFFSSNPFLN-----------SQNQNQNQLP-NDLEILP----YQMSQEQ-------SQNLFNS 1018
            .|.:|:|..:|           |.||...|:. ..:..:|    ..|..||       ..|||
Human  1450 TSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLF-- 1512

  Fly  1019 PHTAPG 1024
            |:..||
Human  1513 PNQLPG 1518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	19/78 (24%)
		PAS	93..153	CDD:214512	21/60 (35%)
		PAS_11	265..368	CDD:464214	28/110 (25%)
NCOA2	XP_016868450.1	bHLH-PAS_NCoA2_SRC2	28..91	CDD:381520	17/59 (29%)
		PAS	118..175	CDD:214512	20/56 (36%)
		PAS_11	268..378	CDD:464214	28/113 (25%)
		NCOA_u2	463..587	CDD:465223	18/123 (15%)
		SRC-1	636..709	CDD:462615	12/74 (16%)
		DUF4927	731..816	CDD:465083	9/84 (11%)
		Nuc_rec_co-act	1071..1115	CDD:462608	7/43 (16%)
		DUF1518	1351..1407	CDD:462174	12/59 (20%)