Protein Alignment Clk and npas2

DIOPT Version :9

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_004911838.1
• Gene: npas2 / 101731519
• XenbaseID: XB-GENE-985239
• Length: 820
• Species: Xenopus tropicalis
• Alignment Length: 873
• Identity: 271/873 - (31%)
• Similarity: 406/873 - (46%)
• Gaps: 183/873 - (20%)

  Fly     4 ESDDKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSSRKMDKSTVLKSTIAFLKNHNEA 68
            :.|:||..:    |.||:.||||||||.|.|:.:||.::..::|::.|:|||:..|.:|:.|||.
 Frog    91 DEDEKDQAR----RASRSKSEKKRRDQLNVLIKELSTMLPENTRRIHKTTVLEKVIGYLQKHNET 151

  Fly    69 TDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNM 133
            ||.:::.:|||||||:||||:|:|.||||:||||::..::.|||.|.|:|||..||:||.|:.:.
 Frog   152 TDETEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTEGSIIYVSDSITPLLGHLPSDIMDQ 216

  Fly   134 TIYDLAYEMDHEALLNIFMNPTPVIEPRQ-TDISSSNQITFYTHLRRGGMEKVDANAYELVKFVG 197
            .:.:...|.:|..:..|..:...|.:... ..::|.|.:.|..||.||.:...:...||.:||||
 Frog   217 NLLNFLPEQEHPDISKILSSHMLVTDTANLNSLNSENNVEFCCHLLRGTLNPKEFPMYEYIKFVG 281

  Fly   198 YF---RNDTNTSTGSSSEVSNGSNGQPAVLPRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSI 259
            .|   .|..||:       .||..|..::   .:|    :::||::..|.|.|:..||.::||.:
 Frog   282 NFWPCSNAPNTT-------CNGFEGPVSM---TYQ----SQLDKQMCLVATVRLATPQFLKEMCM 332

  Fly   260 IDPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGE 324
            .:.:..||||:||:|||||||||||||||||:|.||||||||||||.|||:.:..|||:|.|.|:
 Frog   333 FEESLEEFTSRHSLEWKFLFLDHRAPPIIGYLPIEVLGTSGYDYYHVDDLEILARCHEQLLQCGK 397

  Fly   325 GKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKEGQKSGNSNSI 389
            ||||.|||||||||||||||.||::|||:||||:::||||.||||::|..|.|:|
 Frog   398 GKSCCYRFLTKGQQWIWLQTQYYITYHQWNSKPEFIVCTHNVVSYSDVRVDRRQE---------- 452

  Fly   390 TNNGSSKVIASTGTSSKSASATTTLRDFELSSQNLDSTLLGNSLASLGTETAATSPAVDSSPMWS 454
               .|.:..:|..|.|.....:...:..::.|.:|..:|..|.          :.|.......:|
 Frog   453 ---LSLEEYSSETTVSPELQPSVPCQTCDMQSHSLQQSLQQNQ----------SIPTTQLPAQFS 504

  Fly   455 ASAVQPSGSCQINPLKTSRPASSYGNISSTGISPKAKRKCYFYNNRGNDSDSTSMSTDSVTSRQS 519
            ..|:|                           |...:|              |.:...|:..:|.
 Frog   505 IQAIQ---------------------------SQLQQR--------------TQILQASIQWQQE 528

  Fly   520 MMTHVSSQSQRQRSHHRE---HHRENHHNQSHHHMQQQQQHQNQQQ-----QHQQHQQLQQQLQH 576
            .:..:..|....:..:.:   |.:....|.|:.|..:.|||..||:     |..||..|....|.
 Frog   529 ELKKIQEQLHMVQESNIQIFCHPQTPALNFSNLHQTETQQHPVQQRSSTIPQQPQHIMLSLPTQG 593

  Fly   577 TVGTPKMVPLLPIASTQIMAGNACQFPQPAYPLASPQLVAPTFLEPPQYLTAIPMQPVIAPFPVA 641
            .: ..|::|...:.|:|                        ..|.....|::...:.:.:...::
 Frog   594 QI-ISKLIPGQHVVSSQ------------------------QVLRDSTVLSSKGQKSIRSLHEIS 633

  Fly   642 PVLSPLPVQSQTDMLPD-------TVVMTPTQSQLQDQLQR------KHDELQKLILQQQNELRI 693
            ....| ..::.|..|.|       ::.:.|:....|:.:||      .||...:|:|.|.
 Frog   634 DSAQP-STRNATSQLNDPSSKVTQSLDVVPSSDSQQESIQRSTAPDFSHDRQLRLLLNQP----- 692

  Fly   694 VSEQLLLSRYTYLQPMMSMGFAPGNMTAAAVGNLGASGQRGLNFTGSNAVQPQFNQYGFALNSEQ 758
                        :||||.:                :..:|....||..:...|.:|  ...|.|.
 Frog   693 ------------IQPMMPV----------------SCNKRQTLDTGCQSKYLQNSQ--ILRNVEV 727

  Fly   759 MLNQQDQQMMMQQQQNLHTQHQHNLQQQHQSHSQLQQHTQQQHQQQQQQQQQQQQQQQQQQQQ-- 821
            ..:.....:::..|..||       .....:|...||:.|..|.|||||..|.....|.||..
 Frog   728 QTSGTSAPIVIMGQAILH-------PVVSTTHPSQQQNLQTMHLQQQQQYVQSPSSFQNQQPDSL 785

  Fly   822 ------QQQQQQQQQQQQQLQLQQQNDI 843
                  |||......|||||.|.:...:
 Frog   786 GLPTYAQQQDTIGFHQQQQLTLTRTKSL 813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	HLH	16..68	CDD:238036	24/51 (47%)
		PAS	93..153	CDD:214512	24/59 (41%)
		PAS	264..366	CDD:238075	77/101 (76%)
		PAS_11	265..368	CDD:291273	78/102 (76%)
npas2	XP_004911838.1	bHLH_SF	90..166	CDD:381792	35/78 (45%)
		PAS	173..>241	CDD:366402	26/67 (39%)
		PAS_11	338..441	CDD:373151	78/102 (76%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	197	1.000	Domainoid score	I3042
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002532
OrthoInspector	1	1.000	-	-		otm48926
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1900
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050