Protein Alignment Clk and bmal1

DIOPT Version :10

• Sequence 1: NP_001014576.1
• Gene: Clk / 38872
• FlyBaseID: FBgn0023076
• Length: 1027
• Species: Drosophila melanogaster
• Sequence 2: XP_031756277.1
• Gene: bmal1 / 100422809
• XenbaseID: XB-GENE-495455
• Length: 628
• Species: Xenopus tropicalis
• Alignment Length: 637
• Identity: 156/637 - (24%)
• Similarity: 248/637 - (38%)
• Gaps: 190/637 - (29%)

  Fly     1 MDDESDDKDDTKSFL------CRKSRNLSEKKRRDQFNSLVNDLSALIST---SSRKMDKSTVLK 56
            ||.|.||..:...|.      .|::.:..||:|||:.||.:::|::|:.|   .|||:||.|||:
 Frog    57 MDTEKDDPHELLDFTEGRLRNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLR 121

  Fly    57 STIAFLKNHNEATDRSKVFEIQQDWKPAFLSNDEYTHLMLESLDGFMMVFS-SMGSIFYASESIT 120
            ..:..:|....|.:.    ..:.::||||||:||...|:|.:.|||:.|.. ..|.|.:.|||:.
 Frog   122 MAVQHMKTLRGAANP----YTEANYKPAFLSDDELKQLILRAADGFLFVVGCDRGKILFVSESVF 182

  Fly   121 SQLGYLPQDLYNMTIYDLAYEMD---------------HEALLNIFMNPTPV---IEPRQTDISS 167
            ..|.|...||...:::|..:..|               .|.|::. ....||   |.|..:.:.|
 Frog   183 KILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDA-KTGLPVKTDITPGPSRLCS 246

  Fly   168 SNQITFYTHLR---------------RGGMEKVDANAYELVKFVGYFRNDTNTSTG--SSSEVSN 215
            ..:.:|:..::               ....:|.|..::..:...||.::...|..|  ..:|..|
 Frog   247 GARRSFFCRMKCNRPSVKVEDKDFPSNCSKKKADRKSFCTIHSTGYLKSWPPTKMGLDEDNEPDN 311

  Fly   216 -GSNGQPAVL-----PRIFQQNPNAEVDKKLVFVGTGRVQNPQLIREMSIIDPTSNEFTSKHSME 274
             |.|....|.     |.|..|..|.|:..|                        |.|:.|:|:::
 Frog   312 EGCNLSCLVAIGRLHPHIVPQPANGEIRVK------------------------STEYVSRHAID 352

  Fly   275 WKFLFLDHRAPPIIGYMPFEVLGTSGYDYYHFDDLDSIVACHEELRQTGE--GKSCYYRFLTKGQ 337
            .||:|:|.||..|:||:|.|:||||.|:|:|.||:..:..||:::.||.|  ..:| |:|..|..
 Frog   353 GKFVFVDQRATAILGYLPQELLGTSCYEYFHHDDIGHLADCHKQVLQTREKITTNC-YKFKIKDG 416

  Fly   338 QWIWLQTDYYVSYHQFNSKPDYVVCTHKVVSYAEVLKDSRKEGQKSGNSNSITNNGSSKVIASTG 402
            .:|.|::.::...:.:..:.:|:|.|:.||| |.:|        .:|:|
 Frog   417 SFITLKSRWFSFMNPWTKEVEYIVSTNTVVS-ANIL--------DAGDS---------------- 456

  Fly   403 TSSKSASATTTLRDFELSSQNLDSTLLGNSLASLGTETAATSPAVDSSPMWSASAV--------- 458
                      |......|..::||.|  .|...:......|.|.:.......|..:
 Frog   457 ----------TFSHLSTSPPSMDSVL--QSGEGVTKRNHPTVPGIPGGTRAGAGKIGRMIADEIL 509

  Fly   459 --------QPSGSCQINPLKTSRPASSYGNISST----GISPKAKRKCYFYNNRGND-------- 503
                    .|| ||..:||          |.:||    ..||..|:   ..|..|.|
 Frog   510 EFHRTRGSSPS-SCGSSPL----------NFNSTPPPDASSPGGKK---MSNGGGMDPMSTLVPG 560

  Fly   504 --------SDSTSMSTDSVTSRQSMMTHVSSQSQRQRSHHREHHRENHHNQS 547
                    |||:|:..|:                   ||...:..|..|..|
 Frog   561 MDSSGFPYSDSSSIPGDN-------------------SHMDTYMTETDHGSS 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Clk	NP_001014576.1	bHLH-PAS_dCLOCK	11..86	CDD:381578	25/83 (30%)
		PAS	93..153	CDD:214512	19/75 (25%)
		PAS_11	265..368	CDD:464214	38/104 (37%)
bmal1	XP_031756277.1	bHLH-PAS_ARNTL_PASD3	72..135	CDD:381444	21/62 (34%)
		PAS	154..213	CDD:214512	17/58 (29%)
		PAS_11	344..447	CDD:464214	38/103 (37%)